recent publications
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academic article
- Vale, C., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-jun-n-terminal kinase activation in cultured neurons Toxicological Sciences 2010 113:158-168 DOI:10.1093/toxsci/kfp246 PMID:19815690 PMCID:PMC2794333
- Vale, C., Wandscheer, C., Nicolaou, K. C., Frederick, M. O., Alfonso, C., Vieytes, M. R., Botana, L. M. Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: Involvement of the c-jun n-terminal kinase Journal of Neuroscience Research 2008 86:2952-2962 DOI:10.1002/jnr.21731 PMID:18500761
- Vale, C., Nicolaou, K. C., Frederick, M. O., Gomez-Limia, B., Alfonso, A., Vieytes, M. R., Botana, L. M. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study Journal of Medicinal Chemistry 2007 50:356-363 DOI:10.1021/jm061063g PMID:17228878
- Vale, C., Gomez-Limia, B., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. The c-jun-n-terminal kinase is involved in the neurotoxic effect of azaspiracid-1 Cellular Physiology and Biochemistry 2007 20:957-966 DOI:10.1159/000110457 PMID:17982278