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Plasma measures of beta-endorphin beta-lipotropin-like immunoreactivity in chronic pain syndrome and psychiatric subjects

Academic Article
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Overview

authors

  • Atkinson, J. H.
  • Kremer, E. F.
  • Risch, S. C.
  • Morgan, C. D.
  • Azad, R. F.
  • Ehlers, Cindy
  • Bloom, Floyd

publication date

  • 1983

journal

  • Psychiatry Research  Journal

abstract

  • This study compared basal concentrations of plasma beta-endorphin/beta-lipotropin-like immunoreactivity and dexamethasone suppression of cortisol in seven chronic pain patients, seven psychiatric disorder patients, and seven normal volunteers. Pain patients and psychiatric patients showed significantly higher basal concentrations of beta-endorphin/beta-lipotropin-like immunoreactivity compared to normal volunteers. Pain patients also had significantly higher beta-endorphin/beta-lipotropin-like immunoreactivity than psychiatric patients, even though there was no significant difference in severity of depressive symptomatology as assessed by Beck and Hamilton scores. Resistance to dexamethasone occurred in 57% of pain patients. These results may indicate that biological markers for depression occur in populations of chronic pain patients, or may reflect levels of central nervous system arousal in response to stress, pain, or nonaffective phenomena.

subject areas

  • Adult
  • Alcoholism
  • Chronic Disease
  • Depression
  • Dexamethasone
  • Endorphins
  • Female
  • Humans
  • Hydrocortisone
  • Male
  • Mental Disorders
  • Middle Aged
  • Mood Disorders
  • Pain
  • Radioimmunoassay
  • Syndrome
  • beta-Endorphin
  • beta-Lipotropin
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Identity

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0165-1781(83)90005-7

PubMed ID

  • 6316390
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Additional Document Info

start page

  • 319

end page

  • 327

volume

  • 9

issue

  • 4

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