recent publications

• academic article

  • Chen, M., Handa, M., Roush, W. R. Enantioselective synthesis of 2-methyl-1,2-syn- and 2-methyl-1,2-anti-3-butenediols via allene hydroboration-aldehyde allylboration reaction sequences Journal of the American Chemical Society  2009 131:14602-14603  DOI:10.1021/ja904599h  PMID:19778012  PMCID:PMC2762002
  • Handa, M., Scheidt, K. A., Bossart, M., Zheng, N., Roush, W. R. Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment Journal of Organic Chemistry  2008 73:1031-1035  DOI:10.1021/jo702250z  PMID:18163645
  • Handa, M., Smith, W. J., Roush, W. R. Studies on the synthesis of apoptolidin A. 2. Synthesis of the disaccharide unit Journal of Organic Chemistry  2008 73:1036-1039  DOI:10.1021/jo7022526  PMID:18163646
  • Goto, S., Tamura, N., Li, M., Handa, M., Ikeda, Y., Handa, S., Ruggeri, Z. M. Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity Journal of Thrombosis and Haemostasis  2003 1:2022-2030  DOI:10.1046/j.1538-7836.2003.00349.x  PMID:12941046
  • Ikeda, Y., Handa, M., Kamata, T., Kawano, K., Kawai, Y., Watanabe, K., Kawakami, K., Sakai, K., Fukuyama, M., Itagaki, I., Yoshioka, A., Ruggeri, Z. M. Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation Thrombosis and Haemostasis  1993 69:496-502  PMID:8391728
  • Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Anbo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K., Ruggeri, Z. M. The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress Journal of Clinical Investigation  1991 87:1234-1240  DOI:10.1172/jci115124  PMID:2010539  PMCID:PMC295144
  • Titani, K., Takio, K., Handa, M., Ruggeri, Z. M. Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib Proceedings of the National Academy of Sciences of the United States of America  1987 84:5610-5614  DOI:10.1073/pnas.84.16.5610  PMID:3497398  PMCID:PMC298912
  • Handa, M., Titani, K., Holland, L. Z., Roberts, J. R., Ruggeri, Z. M. The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments Journal of Biological Chemistry  1986 261:2579-2585  PMID:2943738
  • Handa, M., Watanabe, K., Zimmerman, T. S., Ruggeri, Z. M. Structure-function relationships of platelet glycoprotein Ib as a receptor for von Willebrand factor Acta Haematologica Japonica  1986 49:1577-1582  PMID:2436428
  • Takahashi, H., Handa, M., Watanabe, K., Ando, Y., Nagayama, R., Hattori, A., Shibata, A., Federici, A. B., Ruggeri, Z. M., Zimmerman, T. S. Further characterization of platelet-type von Willebrand's disease in Japan Blood  1984 64:1254-1262  PMID:6333901