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Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory

Academic Article
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Overview

authors

  • Mansuy, I. M.
  • Mayford, Mark
  • Jacob, B.
  • Kandel, E. R.
  • Bach, M. E.

publication date

  • January 1998

journal

  • Cell  Journal

abstract

  • To investigate the roles phosphatases play in hippocampal-dependent memory, we studied transgenic mice overexpressing a truncated form of calcineurin. These mice have normal short-term memory but defective long-term memory evident on both a spatial task and on a visual recognition task, providing genetic evidence for the role of the rodent hippocampus in spatial and nonspatial memory. The defect in long-term memory could be fully rescued by increasing the number of training trials, suggesting that the mice have the capacity for long-term memory. We next analyzed mice overexpressing calcineurin in a regulated manner and found the memory defect is reversible and not due to a developmental abnormality. Our behavioral results suggest that calcineurin has a role in the transition from short- to long-term memory, which correlates with a novel intermediate phase of LTP.

subject areas

  • Animals
  • Calcineurin
  • Doxycycline
  • Electric Stimulation
  • Gene Expression
  • Gene Expression Regulation
  • Long-Term Potentiation
  • Maze Learning
  • Memory
  • Memory, Short-Term
  • Mice
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Recombinant Proteins
  • Spatial Behavior
  • Tetracycline
  • Trans-Activators
  • Transgenes
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)80897-1

PubMed ID

  • 9489698
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Additional Document Info

start page

  • 39

end page

  • 49

volume

  • 92

issue

  • 1

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