Journal of Biological Chemistry

articles

A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. 294:6843-6856. 2019
DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. 294:3909-3919. 2019
Milestones in transcription and chromatin published in the Journal of Biological Chemistry. 294:1652-1660. 2019
Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases. 294:5321-5339. 2019
Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers. 294:5616-5631. 2019
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. 294:953-967. 2019
Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures. 294:1846-1859. 2019
A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine. 293:3335-3349. 2018
A global view of structure-function relationships in the tautomerase superfamily. 293:2342-2357. 2018
Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation. 293:13477-13495. 2018
Crystal structure of the human 4-1BB/4-1BBL complex. 293:9880-9891. 2018
Dissecting MMP P-10 and P-11 subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library. 293:16661-16676. 2018
Introduction to the Thematic Minireview Series: Chromatin and transcription. 293:13775-13777. 2018
Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. 293:9388-9398. 2018
Making useful gadgets with miniaturized G proteins. 293:7474-7475. 2018
Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. 293:12259-12270. 2018
Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1. 293:16751-16760. 2018
Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1. 293:11433-11446. 2018
PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. 293:13897-13909. 2018
Phosphoserine acidic cluster motifs bind distinct basic regions on the mu subunits of clathrin adaptor protein complexes. 293:15678-15690. 2018
Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy. 293:13682-13695. 2018
Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers. 293:1688-1701. 2018
Structural basis for disassembly of katanin heterododecamers. 293:10590-10605. 2018
Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody. 293:8439-8448. 2018
The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding. 293:11758-11771. 2018
The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis. 293:4071-4084. 2018
Translation efficiency is maintained at elevated temperature in Escherichia coli. 293:777-793. 2018
Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. 292:8616-8629. 2017
An antidote approach to reduce risk and broaden utility of antibody-based therapeutics. 292:8498-8506. 2017
An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer. 292:15636-15648. 2017
Bacterial polysaccharide specificity of the pattern recognition receptor langerin is highly species- dependent. 292:862-871. 2017
Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development. 292:15121-15132. 2017
Characterization of a stable HIV-1B/C recombinant, soluble, and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes. 292:15849-15858. 2017
Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy. 292:16760-16772. 2017
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. 292:10328-10346. 2017
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing. 292:12653-12666. 2017
Defining minimal binding regions in regulator of presynaptic morphology 1 (RPM-1) using Caenorhabditis elegans neurons reveals differential signaling complexes. 292:2519-2530. 2017
Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase. 292:18518-18529. 2017
Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. 292:11230-11242. 2017
Human milk oligosaccharides inhibit growth of group B Streptococcus. 292:11243-11249. 2017
Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development. 292:2754-2772. 2017
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. 292:14989-15001. 2017
Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. 292:10398-10413. 2017
Secreted glioblastoma nanovesicles contain intracellular signaling proteins and active Ras incorporated in a farnesylation-dependent manner. 292:611-628. 2017
Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein. 292:8236-8243. 2017
Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors. 292:11618-11630. 2017
Targeted Fcγ receptor (FcγR)-mediated clearance by a biparatopic bispecific antibody. 292:4361-4370. 2017
The crystal structure of cytochrome P450 4B1 (CYP4B1) monooxygenase complexed with octane discloses several structural adaptations for ω-hydroxylation. 292:5610-5621. 2017
The major protein arginine methyltransferase in Trypanosoma brucei functions as an enzyme-prozyme complex. 292:2089-2100. 2017
The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans. 292:11861-11872. 2017
Time-course, negative-stain electron microscopy-based analysis for investigating protein-protein interactions at the single-molecule level. 292:19400-19410. 2017
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: Normalization of blood pressure by sodium restriction, hydrochlorothiazide, or blockade of the type 1 angiotensin II receptor. 291:16904-16919. 2016
A new class of allosteric HIV-1 integrase inhibitors identified by crystallographic fragment screening of the catalytic core domain. 291:23569-23577. 2016
Association with the plasma membrane is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily. 291:7195-7204. 2016
Bacterial energy sensor Aer modulates the activity of the chemotaxis kinase CheA based on the redox state of the flavin cofactor. 291:25809-25814. 2016
Branched fatty acid esters of hdroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses. 291:22207-22217. 2016
Chemically programmed bispecific antibodies in diabody format. 291:19661-19673. 2016
Crystal structure and activity studies of the C11 cysteine peptidase from parabacteroides merdae in the human gut microbiome. 291:9482-9491. 2016
Crystal structures of the nuclear receptor, liver receptor homolog 1, bound to synthetic agonists. 291:25281-25291. 2016
Evolution of negative cooperativity in glutathione transferase enabled preservation of enzyme function. 291:26739-26749. 2016
Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a. 291:25965-25982. 2016
Identifying a small molecule blocking antigen presentation in autoimmune thyroiditis. 291:4079-4090. 2016
Increasing the receptor tyrosine kinase EphB2 prevents amyloid-β-induced depletion of cell surface glutamate receptors by a mechanism that requires the PDZ-binding motif of EphB2 and neuronal activity. 291:1719-1734. 2016
Mechanisms and functions of vinculin interactions with phospholipids at cell adhesion sites. 291:2548-2555. 2016
Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane. 291:3423-3438. 2016
Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity. 291:13964-13973. 2016
Poly(ADP-ribose) polymerase 1 represses liver X receptor-mediated ABCA1 expression and cholesterol efflux in macrophages. 291:11172-11184. 2016
Protein arginine methyltransferase product specificity is mediated by distinct active-site architectures. 291:18299-18308. 2016
Regulator of G protein signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein. 291:9133-9147. 2016
Regulatory T cell modulation by CBP/EP300 bromodomain inhibition. 291:13014-13027. 2016
Role for the MED21-MED7 hinge in assembly of the mediator-RNA polymerase II holoenzyme. 291:26886-26898. 2016
Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300. 291:6714-6722. 2016
Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell Lymphoma Models. 291:24628-24640. 2016
Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R). 291:12991-13004. 2016
Targeting stereotyped B cell receptors from chronic lymphocytic leukemia patients with synthetic antigen surrogates. 291:7558-7570. 2016
The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1α transcriptional coactivator. 291:10635-10645. 2016
URI regulates KAP1 phosphorylation and transcriptional repression via PP2A phosphatase in prostate cancer cells. 291:25516-25528. 2016
Unorthodox acetylcholine binding sites formed by α5 and β3 accessory subunits in α4β2* nicotinic acetylcholine receptors. 291:23452-23463. 2016
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes. 290:22919-22930. 2015
The N-terminal domain of Escherichia coli assimilatory NADPH-Sulfite reductase hemoprotein is an oligomerization domain that mediates holoenzyme assembly. 290:19319-19333. 2015
The natural product N-palmitoyl-l-leucine selectively inhibits late assembly of human spliceosomes. 290:27524-27531. 2015
The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. 290:1623-1638. 2015
Tyrosine kinase 2-mediated signal transduction in T lymphocytes is blocked by pharmacological stabilization of Its pseudokinase domain. 290:11061-11074. 2015
A novel α2/α4 subtype-selective positive allosteric modulator of nicotinic acetylcholine receptors acting from the C-tail of an α subunit. 290:28834-28846. 2015
An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors. 290:13907-13918. 2015
Assembly of multi-tRNA synthetase complex via heterotetrameric glutathione transferase-homology domains. 290:29313-29328. 2015
Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding. 290:5092-5104. 2015
Integration of G protein a (Ga) signaling by the regulator of G protein signaling 14 (RGS14). 290:9037-9049. 2015
Orphan receptor GPR158 is an allosteric modulator of RGS7 catalytic activity with an essential role in dictating its expression and localization in the brain. 290:13622-13639. 2015
Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1(SENP1/2). 290:22678-22685. 2015
RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy. 290:5979-5990. 2015
The influence of nitric oxide on soluble guanylate cyclase regulation by nucleotides: Role of the pseudosymmetric site. 290:15570-15580. 2015
The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E. 290:26033-26042. 2015
Thematic minireview series: The state of the cytoskeleton in 2015. 290:17133-17136. 2015
Unmasking of CD22 co-receptor on germinal center B-cells occurs by alternative mechanisms in mouse and man. 290:30066-30077. 2015
A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. 289:10950-10957. 2014
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. 289:13717-13725. 2014
Fragments of bacterial endoglycosidase s and immunoglobulin g reveal subdomains of each that contribute to deglycosylation. 289:13876-13889. 2014
Induction of retinal progenitors and neurons from mammalian Müller glia under defined conditions. 289:11945-11951. 2014
Novel mechanism of hemin capture by Hbp2, the hemoglobin-binding hemophore from Listeria monocytogenes. 289:34886-34899. 2014
Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity. 289:25737-25749. 2014
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation. 289:25750-25763. 2014
Specificity and catalytic mechanism in family 5 uracil DNA glycosylase. 289:18413-18426. 2014
Structural insights into neonatal Fc receptor-based recycling mechanisms. 289:7812-7824. 2014
Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. 289:30101-30113. 2014
A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. 289:26430-26440. 2014
Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics. 289:11421-11430. 2014
Casein kinase 1 delta-dependent Wee1 protein degradation. 289:18893-18903. 2014
Defining the communication between agonist and coactivator binding in the retinoid X receptor alpha ligand binding domain. 289:814-826. 2014
Differential actin-regulatory activities of Tropomodulin1 and Tropomodulin3 with diverse tropomyosin and actin isoforms. 289:11616-11629. 2014
Genomic instability in pluripotent stem cells: implications for clinical applications. 289:4578-4584. 2014
Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication. 289:28910-28923. 2014
Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex. 289:34654-34666. 2014
Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 289:33741-33753. 2014
Introduction to thematic minireview series: Development of human therapeutics based on induced pluripotent stem cell (iPSC) technology. 289:4553-4554. 2014
Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. 289:6551-6564. 2014
Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration. 289:5774-5783. 2014
Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. 289:33557-33567. 2014
RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. 289:2440-2449. 2014
Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway. 289:20307-20317. 2014
Rheb GTPase regulates beta-secretase levels and amyloid beta generation. 289:5799-5808. 2014
Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. 289:3547-3554. 2014
Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis. 289:19269-19275. 2014
Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. 289:1491-1504. 2014
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta/delta (FABP5-PPAR beta/delta) signaling pathway. 289:14941-14954. 2014
Structure of REV-ERB beta ligand-binding domain bound to a porphyrin antagonist. 289:20054-20066. 2014
Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases. 289:35149-35158. 2014
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii. 288:27002-27018. 2013
Characterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactions. 288:21448-21457. 2013
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. 288:12067-12079. 2013
Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. 288:17111-17121. 2013
Enzymatic detoxication, conformational selection, and the role of molten globule active sites. 288:18599-18611. 2013
Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase. 288:2314-2324. 2013
F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. 288:552-560. 2013
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. 288:26926-26943. 2013
Integration and long distance axonal regeneration in the central nervous system from transplanted primitive neural stem cells. 288:164-168. 2013
Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. 288:17360-17371. 2013
Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments. 288:22745-22757. 2013
Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family. 288:13493-13502. 2013
Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface. 288:34956-34967. 2013
[Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. 288:35358-35371. 2013
γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. 288:9710-9720. 2013
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. 288:27872-27880. 2013
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome p450 46a1 unusual features and spectral response. 288:4613-4624. 2013
Blocking c-jun n-terminal kinase (jnk) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo. 288:1079-1087. 2013
Chemotype-selective modes of action of κ-opioid receptor agonists. 288:34470-34483. 2013
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. 288:8445-8455. 2013
Development of functionally selective, small molecule agonists at kappa opioid receptors. 288:36703-36716. 2013
Direct expression and validation of phage-selected peptide variants in mammalian cells. 288:18803-18810. 2013
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors. 288:20702-20712. 2013
Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2. 288:25119-25128. 2013
Energy transducing roles of antiporter-like subunits in Escherichia coli NDH-1 with main focus on subunit NuoN (ND2). 288:24705-24716. 2013
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. 288:29105-29114. 2013
Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at kappa-opioid receptors in striatal neurons. 288:22387-22398. 2013
Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage. 288:2941-2950. 2013
Identification of the low density lipoprotein (ldl) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris. 288:4538-4548. 2013
Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats. 288:4000-4011. 2013
Interferon-induced transmembrane protein 3 is a type II transmembrane protein. 288:32184-32193. 2013
Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells. 288:25129-25142. 2013
Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. 288:25207-25218. 2013
RegB kinase activity is repressed by oxidative formation of cysteine sulfenic acid. 288:4755-4762. 2013
Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases. 288:29223-29228. 2013
Regulation of the structurally dynamic N-terminal domain of progesterone receptor by protein-induced folding. 288:30285-30299. 2013
Semiquinone and cluster N6 signals in His-tagged proton-translocating NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli. 288:14310-14319. 2013
Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. 288:29882-29889. 2013
Structural diversity of eukaryotic membrane cytochrome P450s. 288:17082-17090. 2013
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme. 288:16789-16799. 2013
The redox biochemistry of protein sulfenylation and sulfinylation. 288:26480-26488. 2013
Variable electron transfer pathways in an amphibian cryptochrome: Tryptophan versus tyrosine-based radical pairs. 288:9249-9260. 2013
Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair. 287:41232-41244. 2012
Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1. 287:5891-5897. 2012
Five decades with glutathione and the GSTome. 287:6072-6083. 2012
Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms. 287:23710-23717. 2012
Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis. 287:2079-2089. 2012
Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. 287:38656-38664. 2012
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations. 287:13598-13610. 2012
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. 287:9742-9752. 2012
Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters. 287:43876-43883. 2012
Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. 287:24534-24543. 2012
New class of HIV-1 integrase (IN) inhibitors with a dual mode of action. 287:21189-21203. 2012
Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli. 287:123-133. 2012
Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule. 287:13611-13619. 2012
Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). 287:7357-7365. 2012
Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. 287:28215-28226. 2012
Structural insights into charge pair interactions in triple helical collagen-like proteins. 287:8039-8047. 2012
Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase. 287:37206-37218. 2012
Biochemically defined hiv-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the cd4-binding site. 287:5673-5686. 2012
Chemically programmed bispecific antibodies that recruit and activate T cells. 287:28206-28214. 2012
Constitutive nadph oxidase 4 activity resides in the composition of the b-loop and the penultimate c terminus. 287:8737-8745. 2012
Correlation between NS5A dimerization and hepatitis C virus replication. 287:30861-30873. 2012
Crystal structure of human cytochrome p450 2d6 with prinomastat bound. 287:10834-10843. 2012
CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. 287:21471-21480. 2012
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. 287:2531-2543. 2012
Dhhc5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. 287:523-530. 2012
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. 287:29610-29619. 2012
Electron transfer in subunit nuoi (tyky) of escherichia coli nadh:Quinone oxidoreductase (ndh-1). 287:17363-17373. 2012
Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis. 287:7990-8000. 2012
Enzyme kinetics and interaction studies for human jnk1 beta 1 and substrates activating transcription factor 2 (atf2) and c-jun n-terminal kinase (c-jun). 287:13291-13302. 2012
Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants. 287:12060-12069. 2012
FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability. 287:21914-21925. 2012
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. 287:33781-33795. 2012
Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 287:43053-43062. 2012
Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast. 287:4386-4393. 2012
Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of alpha 1-antitrypsin deficiency. 287:38265-78. 2012
Human protein n-terminal acetyltransferase hnaa50p (hnat5/hsan) follows ordered sequential catalytic mechanism combined kinetic and NMR study. 287:10081-10088. 2012
Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors. 287:183-195. 2012
Identification of a conserved interface between PUF and CPEB proteins. 287:18854-18862. 2012
Kinetic mechanism of protein arginine methyltransferase 6 (prmt6). 287:6062-6071. 2012
L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. 287:22206-22215. 2012
Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular beta-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of beta-O-linked beta-N-acetylglucosaminidase. 287:28882-28897. 2012
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-beta-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes. 287:30024-30034. 2012
Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. 287:21846-21855. 2012
Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. 287:24239-24254. 2012
Protein dynamics and the diversity of an antibody response. 287:27139-27147. 2012
Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis. 287:21599-21614. 2012
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses. 287:31747-31756. 2012
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. 287:11798-11809. 2012
Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. 287:29861-29872. 2012
Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19. 287:44581-44591. 2012
Structural tuning of the fluorescent protein iLOV for improved photostability. 287:22295-22304. 2012
T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements. 287:13324-13335. 2012
Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. 287:17608-17617. 2012
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. 287:43984-43994. 2012
The cytoskeletal protein alpha-catenin unfurls upon binding to vinculin. 287:18492-18499. 2012
Ultrahigh and high resolution structures and mutational analysis of monomeric streptococcus pyogenes speb reveal a functional role for the glycine-rich c-terminal loop. 287:24412-24426. 2012
Uncovering of a short internal peptide activates a tRNA synthetase procytokine. 287:20504-20508. 2012
tRNA-controlled nuclear import of a human tRNA synthetase. 287:9330-9334. 2012
Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase. 286:16871-16878. 2011
Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24. 286:20746-20757. 2011
Identification of a novel Mcl-1 protein binding motif. 286:39829-39835. 2011
Improvement of a potential anthrax therapeutic by computational protein design. 286:32586-32592. 2011
In vitro and in vivo anticancer activity of a synthetic glycolipid as Toll-like receptor 4 (TLR4) activator. 286:43782-43792. 2011
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. 286:11895-11908. 2011
New family of deamination repair enzymes in uracil-DNA glycosylase superfamily. 286:31282-31287. 2011
Structural characterization and epitope mapping of the glutamic acid/alanine-rich protein from Trypanosoma congolense: defining assembly on the parasite cell surface. 286:20658-20665. 2011
The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. 286:19758-19767. 2011
Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities. 286:28435-28443. 2011
Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγt protein. 286:22707-22710. 2011
A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses. 286:22250-22261. 2011
A small molecule that mimics the BB-loop in the Toll Interleukin-1 (IL-1) receptor domain of MyD88 attenuates Staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice. 286:31385-31396. 2011
A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus. 286:6192-6200. 2011
Abrogation of complex glycosylation by swainsonine results in strain- and cell-specific inhibition of prion replication. 286:40962-40973. 2011
Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. 286:31731-31741. 2011
Atp induces conformational changes in the carboxyl-terminal region of clc-5. 286:6733-6741. 2011
Co2+ selectivity of thermotoga maritima cora and its inability to regulate mg2+ homeostasis present a new class of cora proteins. 286:16525-32. 2011
Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. 286. 2011
Deciphering the role of histidine 252 in mycobacterial adenosine 5'-phosphosulfate (APS) reductase catalysis. 286:28567-28573. 2011
Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface. 286:20525-20535. 2011
Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase. 286:11563-11568. 2011
Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation. 286:41489-41498. 2011
Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis. 286:40771-40781. 2011
Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. 286:14983-14990. 2011
Interaction of transducin with uncoordinated 119 protein (UNC119) implications for the model of transducin trafficking in rod photoreceptors. 286:28954-28962. 2011
Liver x receptor-retinoid x receptor (lxr-rxr) heterodimer cistrome reveals coordination of lxr and ap1 signaling in keratinocytes. 286:14554-14563. 2011
Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels. 286:17649-17657. 2011
Mitochondrial c-jun n-terminal kinase (jnk) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation. 286:16052-16062. 2011
Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251. 286:14057-14064. 2011
Munc13-4 restricts motility of rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophils. 286:5647-5656. 2011
Neutralizing mutations of carboxylates that bind metal 2 in t5 flap endonuclease result in an enzyme that still requires two metal ions. 286:30878-30887. 2011
New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases. 286:19422-19430. 2011
Novel vinculin binding site of the IpaA invasin of Shigella. 286:23214-23221. 2011
Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. 286:29718-29724. 2011
Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (tafi) by thrombin. 286:502-510. 2011
Rcl1 protein, a novel nuclease for 18 S ribosomal RNA production. 286:34082-34087. 2011
Reaction mechanism of single subunit nadh-ubiquinone oxidoreductase (ndi1) from saccharomyces cerevisiae evidence for a ternary complex mechanism. 286:9287-9297. 2011
Role of net charge on catalytic domain and influence of cell wall binding domain on bactericidal activity, specificity, and host range of phage lysins. 286:34391-34403. 2011
Roles of Dim2 in ribosome assembly. 286:2578-2586. 2011
Spectroscopic studies on the [4Fe-4S] cluster in adenosine 5'-phosphosulfate reductase from Mycobacterium tuberculosis. 286:1216-1226. 2011
Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni. 286:35922-35932. 2011
Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. 286:17351-17358. 2011
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme cyp11a1. 286:5607-5613. 2011
Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1. 286:5736-5743. 2011
Structural contribution of c-terminal segments of nuol (nd5) and nuom (nd4) subunits of complex i from escherichia coli. 286:34007-34014. 2011
Structural insights into inhibition of bacillus anthracis sporulation by a novel class of non-heme globin sensor domains. 286:8448-8458. 2011
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. 286:7535-7547. 2011
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. 286:10238-10247. 2011
The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. 286:5756-5767. 2011
The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release. 286:33125-33133. 2011
The pH dependence of hairpin ribozyme catalysis reflects ionization of an active site adenine. 286:17658-17664. 2011
The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin. 286:35096-35103. 2011
Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. 286:38456-38465. 2011
Type 5 G protein beta subunit (G beta 5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. 286:21806-21813. 2011
Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential. 286:44254-44265. 2011
Xrcc4 protein interactions with xrcc4-like factor (xlf) create an extended grooved scaffold for DNA ligation and double strand break repair. 286:32638-32650. 2011
Altered chaperone-like activity of α-crystallins promotes cataractogenesis. 285:41187-41193. 2010
Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. 285:25753-25766. 2010
Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. 285:29676-29680. 2010
Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase. 285:16771-16781. 2010
Identification and characterization of the first small molecule inhibitor of MDMX. 285:10786-10796. 2010
Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase. 285:41483-41490. 2010
Identifying divergent HAMP domains and poly-HAMP chains. 285. 2010
LC3-dependent intracellular membrane tubules induced by gamma-protocadherins A3 and B2: a role for intraluminal interactions. 285:20982-20992. 2010
Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase. 285:2351-2360. 2010
Minor modifications of the C-terminal helix reschedule the favored chemical reactions catalyzed by theta class glutathione transferase T1-1. 285:5639-5645. 2010
Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells. 285:29231-29238. 2010
Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. 285:13170-13182. 2010
Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetASE/amidase in redox regulation. 285:25345-25353. 2010
Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning. 285:37281-37292. 2010
The v-myc-induced Q83 lipocalin is a siderocalin. 285:41646-41652. 2010
Transportin regulates nuclear import of CD44. 285:30548-30557. 2010
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. 285:41100-41112. 2010
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. 285:18516-18527. 2010
A novel cross-talk in diacylglycerol signaling the rac-gap beta 2-chimaerin is negatively regulated by protein kinase c delta-mediated phosphorylation. 285:16931-16941. 2010
Activity-based proteomics of enzyme superfamilies: Serine hydrolases as a case study. 285:11051-11055. 2010
Alpha 2,6-sialic acid on platelet endothelial cell adhesion molecule (pecam) regulates its homophilic interactions and downstream antiapoptotic signaling. 285:6515-6521. 2010
Beyond the canonical 20 amino acids: expanding the genetic lexicon. 285:11039-11044. 2010
Characterization of fdmv as an amide synthetase for fredericamycin a biosynthesis in streptomyces griseus atcc 43944. 285:38853-38860. 2010
Characterization of the core mammalian clock component, NPAS2, as a REV-ERB alpha/ROR alpha target gene. 285:35386-35392. 2010
Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2. 285:19959-19966. 2010
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. 285:1909-1918. 2010
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity. 285:25699-25707. 2010
Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters no and o2 binding. 285:17471-17478. 2010
Isolation and characterization of cytoplasmic cofilin-actin rods. 285:5450-5460. 2010
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. 285:1414-1423. 2010
Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. 285:13032-13044. 2010
Lys(842) in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer. 285:3064. 2010
Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities. 285:33265-33280. 2010
Mechanism of aldolase control of sorting nexin 9 function in endocytosis. 285:11983-11990. 2010
Membrane anchor GTPase-accelerating protein activity of RGS11.G beta(5) complex and accelerates inactivation of the mGluR6-G(o) signaling. 285:4781-4787. 2010
Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures. 285:32522-32528. 2010
Methylation of the retinoblastoma tumor suppressor by SMYD2. 285:37733-37740. 2010
Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. 285:5013-5025. 2010
Molecular insights into mammalian end-binding protein heterodimerization. 285:5802-5814. 2010
Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation. 285:31581-31589. 2010
No splicing, no dicing: Non-proteolytic roles of the ubiquitin-proteasome system in transcription. 285:2221-2226. 2010
Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0). 285:20891-20896. 2010
Oxazolomycin biosynthesis in streptomyces albus ja3453 featuring an "acyltransferase-less" type i polyketide synthase that incorporates two distinct extender units. 285:20097-20108. 2010
Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. 285:38602-38611. 2010
Proteolysis-induced n-terminal ectodomain shedding of the integral membrane glycoprotein cub domain-containing protein 1 (cdcp1) is accompanied by tyrosine phosphorylation of its c-terminal domain and recruitment of src and pkc delta. 285:26162-26173. 2010
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. 285:15668-15673. 2010
Regulation of NT-PGC-1 alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. 285:18039-18050. 2010
Repair of o(4)-alkylthymine by o(6)-alkylguanine-DNA alkyltransferases. 285:8185-8195. 2010
Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9. 285:20428-20432. 2010
Structural basis of drug binding to cyp46a1, an enzyme that controls cholesterol turnover in the brain. 285:31783-31795. 2010
Structural basis of o(6)-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. 285:13736-13741. 2010
Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions. 285:27468-27476. 2010
The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. 285:3705-3712. 2010
The membrane subunit nuol(nd5) is involved in the indirect proton pumping mechanism of escherichia coli complex i. 285:39070-39078. 2010
Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. 285:40416-40426. 2010
A human embryonic kidney 293T cell line mutated at the Golgi a-mannosidase II locus.. 284:21684-21695. 2009
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. 284:8023-8032. 2009
Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d. 284:33800-33806. 2009
Porphyrins promote the association of GENOMES UNCOUPLED 4 and a Mg-chelatase subunit with chloroplast membranes. 284:24783-24796. 2009
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation. 284:3917-3924. 2009
Solution structure of an ABC collagen heterotrimer reveals a single-register helix stabilized by electrostatic interactions. 284:26851-26859. 2009
A human germ line antibody light chain with hydrolytic properties associated with multimerization status. 284:33079-33087. 2009
A novel mode of intervention with serine protease activity: targeting zymogen activation. 284:4647-4657. 2009
Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1 alpha. 284:32813-32826. 2009
Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene. 284:14866-14874. 2009
Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation. 284:12949-12955. 2009
Critical roles of subunit nuoh (nd1) in the assembly of peripheral subunits with the membrane domain of escherichia coli ndh-1. 284:9814-9823. 2009
Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis. 284:28968-28976. 2009
Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity. 284:7068-7077. 2009
Features of subunit nuom (nd4) in escherichia coli ndh-1 topology and implication of conserved glu(144) for coupling site 1. 284:33062-33069. 2009
Functional characterization of tlmk unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway. 284:8256-8264. 2009
Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. 284:20387-20397. 2009
Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity. 284:24017-24024. 2009
In vivo investigation of the roles of fdmm and fdmm1 in fredericamycin biosynthesis unveiling a new family of oxygenases. 284:24735-24743. 2009
Increased hydrophobicity at the n terminus/membrane interface impairs gating of the severe combined immunodeficiency-related orai1 mutant. 284:15903-15915. 2009
Iso-migrastatin, migrastatin, and dorrigocin production in streptomyces platensis nrrl 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type i polyketide synthase. 284:29746-29756. 2009
Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia. 284:16752-16758. 2009
Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. 284:33833-33840. 2009
N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. 284:35543-35555. 2009
NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. 284:29666-29676. 2009
Nemo-binding domains of both ikkalpha and ikkbeta regulate ikappab kinase complex assembly and classical nf-kappab activation. 284:27596-27608. 2009
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway. 284:25854-25866. 2009
Non-proteolytic regulation of p53-mediated transcription through destabilization of the activator.promoter complex by the proteasomal ATPases. 284:34522-34530. 2009
Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. 284:16541-16552. 2009
Prion protein-detergent micelle interactions studied by NMR in solution. 284:22713-22721. 2009
Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-fc fusion proteins. 284:34479-34489. 2009
Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. 284:11676-11689. 2009
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes. 284:25268-25279. 2009
Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38. 284:12853-12861. 2009
The RNA-induced silencing complex: A versatile gene-silencing machine. 284:17897-17901. 2009
The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. 284:16998-17005. 2009
The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. 284:3521-3528. 2009
Thioredoxin-related protein 32 is an arsenite-regulated thiol reductase of the proteasome 19 s particle. 284:15233-15245. 2009
p38α and p38γ mediate oncogenic ras-induced senescence through differential mechanisms. 284:11237-11246. 2009
AtNOS/AtNOA1 is a functional Arabidopsis thaliana cGTPase and not a nitric-oxide synthase. 283:32957-32967. 2008
CO2 fixation kinetics of Halothiobacillus neapolitanus mutant carboxysomes lacking carbonic anhydrase suggest the shell acts as a diffusional barrier for CO2. 283:10377-10384. 2008
Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling. 283:12343-12353. 2008
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. 283:16206-16215. 2008
The structure of YqeH. An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition. 283:32968-32976. 2008
A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function. 283:17250-17259. 2008
Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo. 283:12614-12623. 2008
Alternative splicing minireview series: Combinatorial control facilitates splicing regulation of gene expression and enhances genome diversity. 283:1209-1210. 2008
An editing activity that prevents mistranslation and connection to disease. 283:28777-28782. 2008
An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance. 283:36066-36070. 2008
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. 283:9341-9349. 2008
Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas. 283:33087-33093. 2008
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. 283:32254-32263. 2008
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. 283:7713-7720. 2008
Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation. 283:26518-26527. 2008
Characterization of the tautomycin biosynthetic gene cluster from streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis. 283:28607-28617. 2008
Conformational isomerism can limit antibody catalysis. 283:16554-16560. 2008
Detailed mechanisms of the inactivation of factor viiia by activated protein c in the presence of its cofactors, protein s and factor v. 283:16355-16362. 2008
Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. 283:17227-17237. 2008
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. 283:34687-34695. 2008
Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS. 283:2070-2077. 2008
FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. 283:34002-34012. 2008
Functional role for a conserved aspartate in the spo0e signature motif involved in the dephosphorylation of the bacillus subtilis sporulation regulator spo0a. 283:2962-2972. 2008
Histone arg modifications and p53 regulate the expression of okl38, a mediator of apoptosis. 283:20060-20068. 2008
Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins. 283:2098-2107. 2008
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. 283:29-36. 2008
In vivo manipulation of the bleomycin biosynthetic gene cluster in streptomyces verticillus atcc15003 revealing new insights into its biosynthetic pathway. 283:28236-28245. 2008
Iron-sulfur cluster n5 is coordinated by an hxxxcxxcxxxxxc motif in the nuog subunit of escherichia coli nadh : Quinone oxidoreductase (complex i). 283:25979-25987. 2008
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. 283:22490-22497. 2008
Lysophosphatidic acid receptor-dependent secondary effects via astrocytes promote neuronal differentiation. 283:7470-7479. 2008
Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation. 283:30073-30078. 2008
Phosphorylation by casein kinase 1 regulates tonicity-induced osmotic response element-binding protein/tonicity enhancer-binding protein nucleocytoplasmic trafficking. 283:17624-17634. 2008
Physical and functional interactions of monoubiquitylated transactivators with the proteasome. 283:21789-21798. 2008
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases. 283:35402-35409. 2008
Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies. 283:10735-10744. 2008
Regiospecific o-methylation of naphthoic acids catalyzed by ncsb1, an o-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. 283:14694-14702. 2008
Regulation of cholesterologenesis by the oxysterol receptor, lxr alpha. 283:26332-26339. 2008
S1P1 receptor localization confers selectivity for Gi mediated cAMP and contractile responses. 283:11954-11963. 2008
The SBF- and MBF-associated protein Msa1 is required for proper timing of G(1)-specific transcription in Saccharomyces cerevisiae. 283:6040-6049. 2008
The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. 283:33046-33052. 2008
Three metal ions participate in the reaction catalyzed by t5 flap endonuclease. 283:28741-28746. 2008
Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. 283:18734-18742. 2008
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery. 282:11465-11473. 2007
Bacterial flavodoxins support nitric oxide production by bacillus subtilis nitric-oxide synthase. 282:2196-2202. 2007
Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramers are essential for DNA mismatch repair in vivo. 282:16345-16354. 2007
Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of Insigs. 282:27436-27446. 2007
Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. 282:1709-1717. 2007
NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. 282:27562-27571. 2007
Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines. 282:7154-7163. 2007
Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects. 282:2505-2511. 2007
Structure and mechanism of Helicobacter pylori fucosyltransferase: a basis for lipopolysaccharide variation and inhibitor design. 282:9973-9982. 2007
XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. 282:28004-28013. 2007
A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. 282:14309-14315. 2007
A metalloantibody that irreversibly binds a protein antigen. 282:26344-26353. 2007
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions. 282:33022-33033. 2007
Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. 282:14348-14355. 2007
An activated glutamate residue identified in photosystern II at the interface between the manganese-stabilizing subunit and the D2 polypeptide. 282:27802-27809. 2007
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. 282:36714-36723. 2007
Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. 282:35741-35748. 2007
Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from streptomyces atroolivaceus s-140 - discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load d-alanine. 282:20273-20282. 2007
Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. 282:21848-21855. 2007
Characterization of the nuom (nd4) subunit in escherichia coli ndh-1 - conserved charged residues essential for energy-coupled activities. 282:36914-36922. 2007
Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP. 282:31349-31357. 2007
Closing the gate to the active site: Effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase. 282:3829-3836. 2007
Coactivators PGC-1 beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen. 282:26897-26907. 2007
Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 282:897-907. 2007
Dynamics of the hypoxia-inducible factor-1-vascular endothelial growth factor promoter complex. 282:35035-35045. 2007
Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase. 282:4738-4747. 2007
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. 282:15833-15842. 2007
Factor Va residues 311-325 represent an activated protein C binding region. 282:28353-28361. 2007
Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. 282:1518-1528. 2007
Functional analysis of hairpin ribozyme active site architecture. 282:13498-13507. 2007
Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. 282:35964-35977. 2007
Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex. 282:1468-1478. 2007
Identification and characterization of vnx1p, a novel type of vacuolar monovalent cation/h+ antiporter of saccharomyces cerevisiae. 282:24284-24293. 2007
Integration of inositol phosphate signaling pathways via human ITPK1. 282:28117-28125. 2007
Interleukin-1-induced NF-kappaB activation is nemo-dependent but does not require IKKbeta. 282:8724-8733. 2007
LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. 282:4310-4317. 2007
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. 282:7254-7264. 2007
Mechanism of cell death caused by complex i defects in a rat dopaminergic cell line. 282:24146-24156. 2007
Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on toll-like receptor 4, cd44, and md-2. 282:18265-18275. 2007
Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. 282:5225-5236. 2007
Role of a tRNA base modification and its precursors in frameshifting in eukaryotes. 282:26026-26034. 2007
Roles of bound quinone in the single subunit nadh-quinone oxidoreductase (ndi1) from saccharomyces cerevisiae. 282:6012-6020. 2007
Structure of the human lung cytochrome p450 2a13. 282:17306-17313. 2007
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. 282:13033-13046. 2007
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. 282:22939-22952. 2007
The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells. 282:32243-32255. 2007
The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2. 282:4772-4781. 2007
The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. 282:12557-12565. 2007
Three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. 282:36505-36513. 2007
Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity. 282:25416-25424. 2007
Crystal structure of a bifunctional deaminase and reductase from Bacillus subtilis involved in riboflavin biosynthesis. 281:7605-7613. 2006
Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8. 281:38653-38662. 2006
Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics. 281:32784-32795. 2006
Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B. 281:38013-38021. 2006
Structure and reactivity of a thermostable prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex. 281:9623-9632. 2006
The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. 281:26289-26297. 2006
A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from streptomyces griseus. 281:29660-29668. 2006
A second fatty acid amide hydrolase with variable distribution among placental mammals. 281:36569-36578. 2006
A tyrosine-sulfated peptide derived from the heavy-chain CDR3 region of an HIV-1-neutralizing antibody binds gp120 and inhibits HIV-1 infection. 281:28529-28535. 2006
Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation. 281:15997-16005. 2006
Beads-on-a-string, characterization of Ets-1 sumoylated within its flexible N-terminal sequence. 281:4164-4172. 2006
Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor. 281:15951-15958. 2006
Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody. 281:6985-6992. 2006
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for α/β-hydrolase 4 in this pathway. 281:26465-26472. 2006
Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. 281:99-106. 2006
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. 281:15763-15773. 2006
Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. 281:10431-10438. 2006
GPR92 as a new G12/13 and Gq-coupled lysophosphatidic acid receptor that increases cAMP: LPA5. 281:23589-23597. 2006
In vivo complementation of complex i by the yeast ndi1 enzyme - possible application for treatment of parkinson disease. 281:14250-14255. 2006
Localization of sites of interaction between p23 and hsp90 in solution. 281:14457-14464. 2006
Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen chlamydia trachomatis by targeting peptide deformylase of the bacterium. 281:16691-16699. 2006
Multiple activation mechanisms of p38α mitogen-activated protein kinase. 281:26225-26234. 2006
Mutational analysis of membrane and soluble forms of human md-2. 281:11955-11964. 2006
N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. 281:28822-28830. 2006
Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta 1 h-nox domain. 281:21892-21902. 2006
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. 281:20077-20084. 2006
Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. 281:7717-7726. 2006
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. 281:39517-39533. 2006
Reishi polysaccharides induce immunoglobulin production through the tlr4/tlr2-mediated induction of transcription factor blimp-1. 281:24111-24123. 2006
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. 281:3198-3203. 2006
SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association. 281:27973-27981. 2006
Structural and biophysical characterization of the EphB4.ephrinB2 protein-protein interaction and receptor specificity. 281:28185-28192. 2006
Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. 281:34610-34616. 2006
Structural characterization of spo0e-like protein-aspartic acid phosphatases that regulate sporulation in bacilli. 281:37993-38003. 2006
Structure of a membrane-binding domain from a non-enveloped animal virus - insights into the mechanism of membrane permeability and cellular entry. 281:29278-29286. 2006
Structure of microsomal cytochrome p4502b4 complexed with the antifungal drug bifonazole - insight into p450 conformational plasticity and membrane interaction. 281:5973-5981. 2006
Subcellular targeting and differential s-nitrosylation of endothelial nitric-oxide synthase. 281:151-157. 2006
Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. 281:15361-15369. 2006
Substrate specificity of the adenylation enzyme sgcc1 involved in the biosynthesis of the enediyne antitumor antibiotic c-1027. 281:29633-29640. 2006
Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase. 281:36819-36827. 2006
Tab-1 modulates intracellular localization of p38 map kinase and downstream signaling. 281:6087-6095. 2006
The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit. 281:6194-6202. 2006
The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. 281:7228-7236. 2006
Trim5α accelerates degradation of cytosolic capsid associated with productive HIV-1 entry. 281:37025-37033. 2006
Tropomodulin 3 binds to actin monomers. 281:36454-36465. 2006
Widespread, but non-identical, association of proteasomal 19 and 20S proteins with yeast chromatin. 281:27346-27355. 2006
Bacteriophage P22 tail accessory factor GP26 is a long triple-stranded coiled-coil. 280:5929-5933. 2005
Conformational flexibility in crystal structures of human 11 β-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. 280:4639-4648. 2005
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. 280:43048-43055. 2005
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor. 280:36047-36054. 2005
Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA. 280:30581-30585. 2005
Structures of tryptophanyl-tRNA synthetase II from Deinococcus radiodurans bound to ATP and tryptophan. Insight into subunit cooperativity and domain motions linked to catalysis. 280:31965-31973. 2005
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. 280:8060-8068. 2005
A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs. 280:39493-39504. 2005
A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes - crystal structure of human leukocyte antigen (hla)-a1-mage-a1 in complex with fab-hyb3. 280:2972-2980. 2005
A peptide core motif for binding to heterotrimeric G protein α subunits. 280:32057-32060. 2005
Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence. 280:8443-8451. 2005
C-terminal ecfp fusion impairs synaptotagmin 1 function - crowding out synaptotagmin 1. 280:5089-5100. 2005
C-terminal tail residue Arg(1400) enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase. 280:39208-39219. 2005
Characterization of the iron-sulfur cluster n7 (n1c) in the subunit nuog of the proton-translocating nadh-quinone oxidoreductase from escherichia coli. 280:301-307. 2005
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. 280:31405-31412. 2005
Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. 280:22962-22967. 2005
Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a k(+) channel inhibitor-like fold. 280:12405-12412. 2005
Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency. 280:25071-25078. 2005
Cvak104 is a novel poly-l-lysine-stimulated kinase that targets the beta 2-subunit of ap2. 280:21539-21544. 2005
Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. 280:35588-35597. 2005
Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. 280:37616-37622. 2005
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. 280:40169-40176. 2005
Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. 280:24792-24803. 2005
Down-regulation of factor IXa in the factor Xase complex by protein Z-dependent protease inhibitor. 280:33819-33825. 2005
Exploring strategies for the design of artificial transcription factors. 280:3707-3714. 2005
Gamma-globin gene expression in chemical inducer of dimerization (cid)-dependent multipotential cells established from human beta-globin locus yeast artificial chromosome (beta-yac) transgenic mice. 280:36642-36647. 2005
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. 280:42536-42542. 2005
In vivo cleavage of alpha 2,6-sialyltransferase by alzheimer beta-secretase. 280:8589-8595. 2005
Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma 2. 280:14656-14662. 2005
Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells. 280:40293-40300. 2005
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. 280:25313-25322. 2005
Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro. 280:16305-16310. 2005
Preponderance of free mediator in the yeast Saccharomyces cerevisiae. 280:31200-31207. 2005
Protease-activated receptor-1 signaling by activated protein c in cytokine-perturbed endothelial cells is distinct from thrombin signaling. 280:19808-19814. 2005
R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. 280:5133-5136. 2005
Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. 280:10564-10571. 2005
Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. 280:8343-8350. 2005
Sox9 and p300 cooperatively regulate chromatin-mediated transcription. 280:35203-35208. 2005
Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. 280:34278-34287. 2005
Structure and lytic activity of a bacillus anthracis prophage endolysin. 280:35433-35439. 2005
Tetrameric architecture of the circadian clock protein KaiB - a novel interface for intermolecular interactions and its impact on the circadian rhythm. 280:19127-19135. 2005
The inv(16) cooperates with arf haploinsufficiency to induce acute myeloid leukemia. 280:40097-40103. 2005
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle. 280:21908-21914. 2005
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation. 280:8929-8935. 2005
Translocation of dynorphin neuropeptides across the plasma membrane - a putative mechanism of signal transmission. 280:26360-26370. 2005
VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. 280:2405-2408. 2005
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. 280:23815-23819. 2005
A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles. 279:19018-19025. 2004
A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. 279:29615-29621. 2004
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling. 279:2125-2134. 2004
Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences. 279:18717-18726. 2004
Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. 279:40337-40344. 2004
Functional role of the lock and key motif at the subunit interface of glutathione transferase P1-1. 279:9586-9596. 2004
Identification of novel binding elements and gene targets for the homeodomain protein BARX2. 279:14520-14530. 2004
Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. 279:27584-27590. 2004
Regioselective nitration of tryptophan by a complex between bacterial nitric-oxide synthase and tryptophanyl-tRNA synthetase. 279:49567-49570. 2004
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis. 279:8526-8529. 2004
The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme. 279:32684-32691. 2004
The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. 279:1141-1150. 2004
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. 279:3197-3201. 2004
Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. 279:1581-1584. 2004
Activation of the redox-regulated chaperone hsp33 by domain unfolding. 279:20529-20538. 2004
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase. 279:5861-5866. 2004
Assembly of respiratory complexes i, iii, and iv into nadh oxidase supercomplex stabilizes complex i in paracoccus denitrificans. 279:5000-5007. 2004
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. 279:14509-14519. 2004
Bacillus subtilis chec and fliy are members of a novel class of chey-p-hydrolyzing proteins in the chemotactic signal transduction cascade. 279:21787-21792. 2004
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. 279:3817-3827. 2004
Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. 279:32079-32086. 2004
Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. 279:14245-14255. 2004
Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3). 279:27633-27645. 2004
Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity. 279:8111-8115. 2004
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. 279:50555-50565. 2004
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. 279:18034-18045. 2004
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. 279:17283-17288. 2004
Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. 279:55754-55759. 2004
Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation. 279:10564-10574. 2004
DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe. 279:53023-53027. 2004
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. 279:1867-1871. 2004
Dynamin gtpase domain mutants that differentially affect gtp binding, gtp hydrolysis, and clathrin-mediated endocytosis. 279:40431-40436. 2004
Factor XI interacts with the leucine-rich repeats of glycoprotein Ib alpha on the activated platelet. 279:49323-49329. 2004
Functional roles of four conserved charged residues in the membrane domain subunit nuoa of the proton-translocating nadh-quinone oxidoreductase from escherichia coli. 279:32360-32366. 2004
Global analysis of protein sumoylation in Saccharomyces cerevisiae. 279:45662-45668. 2004
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. 279:1050-1059. 2004
Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2. 279:38409-38414. 2004
Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. 279:6280-6285. 2004
Induced fit movements and metal cofactor selectivity of class ll aldolases - structure of Thermus aquaticus fructose-1,6-bisphosphate aldolase. 279:11825-11833. 2004
Interaction interface of human flap endonuclease-1 with its DNA substrates. 279:24394-24402. 2004
Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. 279:16875-16882. 2004
Interaction of the taz1 domain of the creb-binding protein with the activation domain of cited2 - regulation by competition between intrinsically unstructured ligands for non-identical binding sites. 279:3042-3049. 2004
Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue. 279:28339-28344. 2004
Kinetic and stability properties of Penicillium chrysogenum ATP sulfurylase missing the C-terminal regulatory domain. 279:4415-4424. 2004
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. 279:17634-17639. 2004
Lysophospholipid G protein-coupled receptors. 279:20555-20558. 2004
Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction. 279:21651-21657. 2004
Negative regulation of t cell receptor signaling by siglec-7 (p70/airm) and siglec-9. 279:43117-43125. 2004
Neural cell adhesion molecule (n-cam) homophilic binding mediated by the two n-terminal ig domains is influenced by intramolecular domain-domain interactions. 279:49633-49643. 2004
P21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized RHO exchange factor. 279:18392-18400. 2004
Peanut agglutinin high phenotype of activated cd8(+) t cells results from de novo synthesis of cd45 glycans. 279:36689-36697. 2004
Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1). 279:37528-37534. 2004
Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. 279:23038-23044. 2004
Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. 279:22331-22346. 2004
Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex. 279:49019-49025. 2004
Reaction intermediates in the catalytic mechanism of escherichia coli muty DNA glycosylase. 279:46930-46939. 2004
Sphingolipids as bioactive regulators of thrombin generation. 279:12036-12042. 2004
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. 279:13839-13848. 2004
Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. 279:49131-49137. 2004
Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica. 279:24197-24202. 2004
Structural basis for amplifying vinculin activation by talin. 279:27667-27678. 2004
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. 279:37918-37927. 2004
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. 279:9497-9503. 2004
Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. 279:27294-27301. 2004
Structure-activity relationship of synthetic toll-like receptor 4 agonists. 279:4440-4449. 2004
TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. 279:14752-14762. 2004
The NS5A protein of hepatitis C virus is a zinc metalloprotein. 279:48576-48587. 2004
The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1. 279:22595-22604. 2004
The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. 279:42811-42817. 2004
The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0 Å resolution. 279:35630-35637. 2004
The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution. 279:38091-38094. 2004
Trans-inactivation of receptor tyrosine kinases by novel angiotensin ii at2 receptor-interacting protein, atip. 279:28989-28997. 2004
Translation of a yeast mitochondrial tRNA synthetase initiated at redundant non-AUG codons. 279:49656-49663. 2004
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase P1-1. 278:1291-1302. 2003
Convulxin binds to native, human glycoprotein IIbα. 278:39452-39460. 2003
Crystal structure of Pasteurella haemolytica ferric ion-binding protein a reveals a novel class of bacterial iron-binding proteins. 278:41093-41098. 2003
Identification of residues in glutathione transferase capable of driving functional diversification in evolution - A novel approach to protein redesign. 278:8733-8738. 2003
Nanomolar affinity small molecule correctors of defective ΔF508-CFTR chloride channel gating. 278:35079-35085. 2003
Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase. 278:38860-38869. 2003
Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity - Different oligomers activate different signal transduction pathways. 278:50810-50817. 2003
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. 278:42020-42026. 2003
κB-Ras binds to the unique insert within the ankyrin repeat domain of IκBβ and regulates cytoplasmic retention of IκBβ·NF-κB complexes. 278:23101-23106. 2003
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor. 278:2403-2410. 2003
Adp-ribosylation factor 4 small gtpase mediates epidermal growth factor receptor-dependent phospholipase d2 activation. 278:2661-2668. 2003
Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. 278:42750-42760. 2003
Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis. 278:1131-1136. 2003
Apolipoprotein a-ii inhibits high density lipoprotein remodeling and lipid-poor apolipoprotein a-i formation. 278:22530-22536. 2003
BACE1- and BACE2-expressing human cells - characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors. 278:25859-25866. 2003
Bacillus subtilis hydrolyzes chey-p at the location of its action, the flagellar switch. 278:48611-48616. 2003
Characterization of cluster n5 as a fast-relaxing 4fe-4s cluster in the nqo3 subunit of the proton-translocating nadh-ubiquinone oxidoreductase from paracoccus denitrificans. 278:15514-15522. 2003
Co-translational targeting and translocation of the amino terminus of opsin across the endoplasmic membrane requires gtp but not atp. 278:7920-7926. 2003
Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling. 278:29863-29872. 2003
Curariform antagonists bind in different orientations to acetylcholine-binding protein. 278:23020-23026. 2003
Essential glycine in the proton channel of escherichia coli transhydrogenase. 278:45333-45339. 2003
Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase. 278:37393-37399. 2003
Expression profiling identifies genes that continue to respond to insulin in adipocytes made insulin-resistant by treatment with tumor necrosis factor-alpha. 278:52298-52306. 2003
Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles. 278:14614-14621. 2003
Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. 278:8904-8912. 2003
IKKi/IKK epsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. 278:26612-26619. 2003
Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. 278:33312-33318. 2003
Identification of drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 278:52172-52178. 2003
Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. 278:47812-47819. 2003
Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma. 278:8637-8644. 2003
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor. 278:3378-3385. 2003
Lipopolysaccharide (lps)-binding protein inhibits responses to cell-bound lps. 278:28367-28371. 2003
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappa B independently of platelet-activating factor. 278:45034-45039. 2003
Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. 278:31426-31433. 2003
Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex. 278:45460-45467. 2003
Observation of an arsenic adduct in an acetyl esterase crystal structure. 278:2008-2014. 2003
Protection of islets by in situ peptide-mediated transduction of the I kappa B kinase inhibitor nemo-binding domain peptide. 278:9862-9868. 2003
Proteomic characterization of the Chlamydomonas reinhardtii chloroplast ribosome. Identification of proteins unique to th e70 S ribosome. 278:33774-33785. 2003
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase 1/erk5 but not erk1/2 kinase activation. 278:18682-18688. 2003
Secretory iga n- and o-glycans provide a link between the innate and adaptive immune systems. 278:20140-20153. 2003
Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. 278:7413-7421. 2003
Sialoside specificity of the siglec family assessed using novel multivalent probes - identification of potent inhibitors of myelin-associated glycoprotein. 278:31007-31019. 2003
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. 278:46452-46460. 2003
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. 278:40330-40336. 2003
Structure-specific tRNA determinants for editing a mischarged amino acid. 278:45056-45061. 2003
Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. 278:37902-37908. 2003
Synergy of silent and hot spot mutations in importin beta reveals a dynamic mechanism for recognition of a nuclear localization signal. 278:16216-16221. 2003
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. 278:30854-30858. 2003
The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II. 278:8897-8903. 2003
The homeodomain protein barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors. 278:8269-8278. 2003
The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements. 278:33793-33800. 2003
The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase-activating polypeptide-(1-38). 278:22418-22423. 2003
The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha). 278:9013-9018. 2003
Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. 278:27224-27229. 2003
Tropomodulin contains two actin filament pointed end-capping domains. 278:40000-40009. 2003
delta BAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. 278:38220-38228. 2003
Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3. 277:16648-16654. 2002
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. 277:40181-40184. 2002
Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase. 277:38870-38876. 2002
Oligomerization state-dependent activation of NF-NF-κB signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). 277:29359-29362. 2002
Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase. 277:30019-30022. 2002
A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells. 277:7420-7429. 2002
A single-domain cyclophilin from Leishmania donovani reactivates soluble aggregates of adenosine kinase by isomerase-independent chaperone function. 277:47451-47460. 2002
Active site residues of cyclophilin A are crucial for its signaling activity via CD147. 277:22959-22965. 2002
An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase. 277:7377-7385. 2002
Axonin-1/TAG-1 mediates cell-cell adhesion by a cis-assisted trans-interaction. 277:4551-4557. 2002
Azotobacter vinelandii ferredoxin i - a sequence and structure comparison approach to alteration of 4fe-4s 2(+/+) reduction potential. 277:5603-5610. 2002
Biochemical characterization of aspartyl phosphate phosphatase interaction with a phosphorylated response regulator and its inhibition by a pentapeptide. 277:20483-20489. 2002
Characterization of the iron-sulfur cluster coordinated by a cysteine cluster motif (cxxcxxxcx27c) in the nqo3 subunit in the proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermus thermophilus hb-8. 277:1680-1688. 2002
Cooperativity in transcription factor binding to the coactivator creb-binding protein (cbp) - the mixed lineage leukemia protein (mll) activation domain binds to an allosteric site on the kix domain. 277:43168-43174. 2002
Cyclin I is an RS domain protein involved in pre-mRNA splicing. 277:25465-25473. 2002
Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. 277:31020-31030. 2002
Effects of nitroglycerin on soluble guanylate cyclase: Implications for nitrate tolerance. 277:18253-18256. 2002
Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate. 277:30208-30218. 2002
Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment. 277:907-911. 2002
Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication. 277:32036-32045. 2002
Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases. 277:45729-45733. 2002
Identification of the disulfide bonds in the recombinant somatomedin B domain of human vitronectin. 277:27109-27119. 2002
Identification of the tRNA-dihydrouridine synthase family. 277:25090-25095. 2002
Ilpip, a novel anti-apoptotic protein that enhances xiap-mediated activation of jnk1 and protection against apoptosis. 277:30454-30462. 2002
Immunosuppressive effects of glucosamine. 277:39343-39349. 2002
Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase. 277:20124-20126. 2002
Kinetic analysis of the interaction between vitronectin and the urokinase receptor. 277:9395-9404. 2002
Kinetic mechanism of activation of the cdk2/cyclin a complex. 277:23847-23853. 2002
Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha(IIb)beta(3). 277:11949-11956. 2002
Localization of carbohydrate attachment sites and disulfide bridges in limulus alpha(2)-macroglobulin - evidence for two forms differing primarily in their bait region sequences. 277:43698-43706. 2002
Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. 277:38579-38588. 2002
Loss of p53 compensates for alpha(v)-integrin function in retinal neovascularization. 277:13371-13374. 2002
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1p) receptors, S1p(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. 277:25152-25159. 2002
Md-2 and tlr4 n-linked glycosylations are important for a functional lipopolysaccharide receptor. 277:1845-1854. 2002
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. 277:10394-10399. 2002
Misexpression of the eyes absent family triggers the apoptotic program. 277:3560-3567. 2002
Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C. 277:28836-28840. 2002
Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S. 277:8861-8865. 2002
Non-conventional trafficking of the cystic fibrosis transmembrane conductance regulator through the early secretory pathway. 277:11401-11409. 2002
Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity. 277:32843-32848. 2002
Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the crib/sh3-binding region. 277:24728-24734. 2002
Peroxisome proliferator-activated receptor (ppar) gamma coactivator-1 recruitment regulates ppar subtype specificity. 277:16750-16757. 2002
Pgc-1 functions as a transcriptional coactivator for the retinoid x receptors. 277:3913-3917. 2002
Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin. 277:33564-33570. 2002
Plasticity of recognition of the 3'-end of mischarged tRNA by class I aminoacyl-tRNA synthetases. 277:20510-20517. 2002
Processing of integrin αv subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase. 277:9749-9756. 2002
Protein-rna interactions and virus stability as probed by the dynamics of tryptophan side chains. 277:47596-47602. 2002
Regulated expression of the apolipoprotein e/c-i/c-iv/c-ii gene cluster in murine and human macrophages - a critical role for nuclear liver x receptors alpha and beta. 277:31900-31908. 2002
Requirement of helix 1 and the af-2 domain of the thyroid hormone receptor for coactivation by pgc-1. 277:8898-8905. 2002
Roles of phosphorylation and helix propensity in the binding of the kix domain of creb-binding protein by constitutive (c-myb) and inducible (creb) activators. 277:42241-42248. 2002
Specific binding of RGS9-G beta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity. 277:24376-24381. 2002
Stimulation of enveloped virus infection by beta-amyloid fibrils. 277:35019-35024. 2002
Substitution of ribonucleotides in the T7 RNA polymerase promoter element. 277:2987-2991. 2002
The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. 277:35105-35112. 2002
The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. 277:13918-13925. 2002
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR. 277:9318-9325. 2002
The proton channel of the energy-transducing nicotinamide nucleotide transhydrogenase of escherichia coli. 277:33670-33675. 2002
The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 alpha association and HIV-1 entry. 277:29484-29489. 2002
Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein. 277:41299-41302. 2002
Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region. 277:40397-40402. 2002
Unique ability of integrin alpha(v)beta(3) to support tumor cell arrest under dynamic flow conditions. 277:21930-21938. 2002
Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane ss-sheet from a prepore intermediate. 276:8261-8268. 2001
Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. 276:33061-33065. 2001
Human glutathione transferase Al-1 demonstrates both half-of-the-sites and all-of-the-sites reactivity. 276:35599-35605. 2001
The LG3 module of laminin-5 harbors a binding site for integrin α3β1 that promotes cell adhesion, spreading, and migration. 276:33045-33053. 2001
The folding and stability of human alpha class glutathione transferase A1-1 depend on distinct roles of a conserved N-capping box and hydrophobic staple motif. 276:32177-32183. 2001
Yeast glyoxalase I is a monomeric enzyme with two active sites. 276:1845-1849. 2001
A 5' leader of Rbm3, a cold stress-induced mRNA, mediates internal initiation of translation with increased efficiency under conditions of mild hypothermia. 276:36917-36922. 2001
A catalytic antibody produces fluorescent tracers of gap junction communication in living cells. 276:49164-49168. 2001
Bmk1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. 276:8631-8634. 2001
C-myc-mediated regulation of telomerase activity is disabled in immortalized cells. 276:29994-30001. 2001
Caspase remodeling of the spectrin membrane skeleton during lens development and aging. 276:20735-20742. 2001
Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70. 276:26004-26011. 2001
Characterization of inherited differences in transcription of the human integrin alpha(2) gene. 276:23518-23524. 2001
Circadian regulation of diverse gene products revealed by mRNA expression profiling of synchronized fibroblasts. 276:46751-46758. 2001
Conserved cysteines in the sialyltransferase sialylmotifs form an essential disulfide bond. 276:15200-15207. 2001
Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface. 276:19078-19083. 2001
Demonstration of direct effects of growth hormone on neonatal cardiomyocytes. 276:22892-22900. 2001
Development of zinc finger domains for recognition of the 5 '-ann-3 ' family of DNA sequences and their use in the construction of artificial transcription factors. 276:29466-29478. 2001
Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. 276:25946-25952. 2001
Fragile T-stem in disease-associated human mitochondrial tRNA sensitizes structure to local and distant mutations. 276:10607-10611. 2001
Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins b cell linker protein and slp-76 in lymphocytes. 276:45207-45216. 2001
Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III. 276:8231-8238. 2001
Identification of a motif in the carboxyl terminus of β-arrestin2 responsible for activation of JNK3. 276:27770-27777. 2001
Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor a in HepG2 cells. 276:27950-27958. 2001
In vitro analysis of nuclear transport mediated by the c-terminal shuttle domain of tap. 276:42355-42363. 2001
Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7α-hydroxylase. 276:23304-23311. 2001
JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. 276:18855-18862. 2001
Lack of complex i activity in human cells carrying a mutation in mtdna-encoded nd4 subunit is corrected by the saccharomyces cerevisiae nadh-quinone oxidoreductase (ndi1) gene. 276:38808-38813. 2001
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2. 276:21129-21135. 2001
Lung Kruppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. 276:29299-29306. 2001
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion. 276:18415-18422. 2001
Md-2 binds to bacterial lipopolysaccharide. 276:38044-38051. 2001
Molecular cloning of mouse erk5/bmk1 splice variants and characterization of erk5 functional domains. 276:10870-10878. 2001
Molecular mechanism of aminoglycoside antibiotic kinase aph(3 ')-iiia - roles of conserved active site residues. 276:23929-23936. 2001
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells. 276:25705-25714. 2001
Mutations in the G-domain of elongation factor G from thermus thermophilus affect both its interaction with GTP and fusidic acid. 276:28774-28778. 2001
Operational RNA code for amino acids in relation to genetic code in evolution. 276:6881-6884. 2001
P53 latency - c-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences. 276:15650-15658. 2001
PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45. 276:7637-7642. 2001
Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. 276:25022-25029. 2001
Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a. 276:179-186. 2001
Receptor and membrane recycling can occur with unaltered efficiency despite dramatic rab5(q79l)-induced changes in endosome geometry. 276:9649-9654. 2001
Recombinant cytochrome rc(557) obtained from escherichia coli cells expressing a truncated thermus thermophilus cyca gene - heme inversion in an improperly matured protein. 276:6537-6544. 2001
Reconstitution of pterin-free inducible nitric-oxide synthase. 276:421-427. 2001
Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal. 276:16952-16959. 2001
Residue met(156) contributes to the labile enzyme conformation of coagulation factor viia. 276:6616-6620. 2001
Rgs9-g beta 5 substrate selectivity in photoreceptors - opposing effects of constituent domains yield high affinity of rgs interaction with the g protein-effector complex. 276:37365-37372. 2001
Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2. 276:10063-10071. 2001
Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, lPB3/EDG-3. 276:33697-33704. 2001
Specific interaction of angiostatin with integrin alpha(v)beta(3) in endothelial cells. 276:39562-39568. 2001
Stimulation of nuclear export and inhibition of nuclear import by a ran mutant deficient in binding to ran-binding protein 1. 276:14524-14531. 2001
Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease. 276:19396-19403. 2001
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. 276:29282-29291. 2001
The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. 276:583-592. 2001
The gal4 activation domain binds sug2 protein, a proteasome component, in vivo and in vitro. 276:30956-30963. 2001
The low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor is a receptor for connective tissue growth factor. 276:40659-40667. 2001
The mechanism of the remodeling of high density lipoproteins by phospholipid transfer protein. 276:26898-26905. 2001
The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif. 276:13314-13321. 2001
Transcriptional coactivator protein p300 - kinetic characterization of its histone acetyltransferase activity. 276:33721-33729. 2001
Two novel xenopus homologs of mammalian lPA1/EDG-2 function as lysophosphatidic acid receptors in xenopus oocytes and mammalian cells. 276:15208-15215. 2001
Type ii transmembrane serine proteases - insights into an emerging class of cell surface proteolytic enzymes. 276:857-860. 2001
Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib. 276:21173-21183. 2001
Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. 276:17958-17967. 2001
A conserved "hydrophobic staple motif" plays a crucial role in the refolding of human glutathione transferase P1-1. 275:10421-10428. 2000
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2 - Evidence against proposed sulfatase activity of the corresponding human enzyme. 275:8618-8624. 2000
Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. 275:30537-30545. 2000
Functional cloning of an Arabidopsis thaliana cDNA encoding cycloeucalenol cycloisomerase. 275:13394-13397. 2000
Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK1 cells. 275:10278-10284. 2000
A cdc6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 275:32098-32105. 2000
A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis. 275:5754-5759. 2000
A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry. 275:33516-33521. 2000
Association of p130(cas) with phosphatidylinositol-3-oh kinase mediates adenovirus cell entry. 275:14729-14735. 2000
Big mitogen-activated kinase regulates multiple members of the mef2 protein family. 275:18534-18540. 2000
Biochemical characterization of the tata-binding protein-gal4 activation domain complex. 275:31914-31920. 2000
Chemically regulated zinc finger transcription factors. 275:32617-32627. 2000
Clarifying the catalytic roles of conserved residues in the amidase signature family. 275:19177-19184. 2000
Cu2+ and zn2+ inhibit nitric-oxide synthase through an interaction with the reductase domain. 275:14070-14076. 2000
Domain III of elongation factor G from thermus thermophilus is essential for induction of GTP hydrolysis on the ribosome. 275:35820-35824. 2000
Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding. 275:2545-2553. 2000
Exosite interactions determine the affinity of factor x for the extrinsic xase complex. 275:28826-28833. 2000
Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (cacna2d2). 275:12237-12242. 2000
Functional redundancy in the nonspecific RNA binding domain of a class I tRNA synthetase. 275:17180-17186. 2000
Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization. 275:36073-36078. 2000
Homophilic interaction of junctional adhesion molecule. 275:30970-30976. 2000
Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage. 275:12410-12415. 2000
Induction of positive cooperativity by amino acid replacements within the C-terminal domain of penicillium chrysogenum ATP sulfurylase. 275:36303-36310. 2000
Kinase signaling initiates coat complex II (COPII) recruitment and export from the mammalian endoplasmic reticulum. 275:35673-35676. 2000
Kinetic and spectroscopic evidence for three actomyosin : Adp states in smooth muscle. 275:25418-25426. 2000
Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ib alpha. 275:12763-12768. 2000
Monitoring enzyme catalysis with mass spectrometry. 275:13455-13459. 2000
Multiple o-glycoforms on the spore coat protein sp96 in dictyostelium discoideum - fuc(alpha 1-3)glcnac-alpha-1-p-ser is the major modification. 275:12164-12174. 2000
Nuclear import adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70. 275:4298-4304. 2000
One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions. 275:27681-27688. 2000
PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. 275:9773-9781. 2000
Peptides selected to bind the ga180 repressor are potent transcriptional activation domains in yeast. 275:14979-14984. 2000
Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro. 275:17848-17856. 2000
Protection of human islets from the effects of interleukin-1 beta by adenoviral gene transfer of an I kappa B repressor. 275:36509-36513. 2000
Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. 275:35734-35737. 2000
Regulation of transporter associated with antigen processing by phosphorylation. 275:24130-24135. 2000
Serine 727 phosphorylation and activation of cytosolic phospholipase A(2) by MNK1-related protein kinases. 275:37542-37551. 2000
Single repeat deletion in apoa-i blocks cholesterol esterification and results in rapid catabolism of delta 6 and wild-type apoa-i in transgenic mice. 275:12156-12163. 2000
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. 275:18108-18113. 2000
Structure of c42d azotobacter vinelandii fdi - a cys-x-x-asp-x-x-cys motif ligates an air-stable 4fe-4s (2+/+) cluster. 275:36974-36983. 2000
Structure-function analysis of cd14 as a soluble receptor for lipopolysaccharide. 275:3144-3149. 2000
Substituting selenocysteine for catalytic cysteine 41 enhances enzymatic activity of plant phospholipid hydroperoxide glutathione peroxidase expressed in escherichia coli. 275:28715-28721. 2000
Tata-binding protein and the gal4 transactivator do not bind to promoters cooperatively. 275:40797-40803. 2000
The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity. 275:6267-6275. 2000
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. 275:26661-26664. 2000
The isolation, characterization, and molecular cloning of a 75-kda gelatinase b-like enzyme, a member of the matrix metalloproteinase (mmp) family - an avian enzyme that is mmp-9-like in its cell expression pattern but diverges from mammalian gelatinase b in sequence and biochemical properties. 275:40827-40838. 2000
The mechanism of action of inhibitors of bacterial two-component signal transduction systems. 275:38900-38904. 2000
The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies. 275:13668-13676. 2000
The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents. 275:36394-36399. 2000
Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations. 275:27933-27939. 2000
Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38 alpha mitogen-activated protein kinase activity. 275:12266-12272. 2000
Use of the nadh-quinone oxidoreductase (ndi1) gene of saccharomyces cerevisiae as a possible cure for complex i defects in human cells. 275:37774-37778. 2000
Virus maturation targets the protein capsid to concerted disassembly and unfolding. 275:16037-16043. 2000
Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22. 274:2303-2307. 1999
Molecular dissection of guanine nucleotide dissociation inhibitor function in vivo - Rab-independent binding to membranes and role of Rab recycling factors. 274:14806-14817. 1999
Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody. 274:27371-27378. 1999
A di-acidic (DxE) code directs concentration of cargo during export from the endoplasmic reticulum. 274:15937-15946. 1999
A molecular model of alzheimer amyloid beta-peptide fibril formation. 274:12619-12625. 1999
ATP and the core "alpha-crystallin" domain of the small heat-shock protein alpha B-crystallin. 274:30190-30195. 1999
Activation of matrix metalloproteinase-9 (mmp-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. 274:13066-13076. 1999
Alteration of the reduction potential of the 4fe-4s (2+/+) cluster of azotobacter vinelandii ferredoxin i. 274:36479-36487. 1999
Antifungal imidazoles block assembly of inducible no synthase into an active dimer. 274:930-938. 1999
Association of neuronal calcium channels with modular adaptor proteins. 274:24453-24456. 1999
Beta(2)-adrenergic receptor down-regulation - evidence for a pathway that does not require endocytosis. 274:28900-28908. 1999
C-terminal residues 621-635 of protein S are essential for binding to factor Va. 274:36187-36192. 1999
Cargo can modulate COPII vesicle formation from the endoplasmic reticulum. 274:4389-4399. 1999
Characterization of the putative 2x 4fe-4s -binding nqo9 subunit of the proton-translocating nadh-quinone oxidoreductase (ndh-1) of paracoccus denitrificans - expression, reconstitution, and epr characterization. 274:28598-28605. 1999
Complex formation between azotobacter vinelandii ferredoxin i and its physiological electron donor nadph-ferredoxin reductase. 274:2978-2987. 1999
Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ib alpha under flow. 274:6586-6593. 1999
Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor. 274:28745-28750. 1999
Expression of α2,8/2,9-polysialyltransferase from escherichia coli K92 - characterization of the enzyme and its reaction products. 274:35139-35146. 1999
Fluid shear stress stimulates big mitogen-activated protein kinase 1 (bmk1) activity in endothelial cells - dependence on tyrosine kinases and intracellular calcium. 274:143-150. 1999
Genetically encoded and post-translationally modified forms of a major histocompatibility complex class i-restricted antigen bearing a glycosylation motif are independently processed and co-presented to cytotoxic t lymphocytes. 274:36274-36280. 1999
H+-translocating nadh-quinone oxidoreductase (ndh-1) of paracoccus denitrificans - studies on topology and stoichiometry of the peripheral subunits. 274:28606-28611. 1999
Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. 274:23155-23159. 1999
Identification of NSF as a beta-arrestin1-binding protein - implications for beta(2)-adrenergic receptor regulation. 274:10677-10680. 1999
Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle. 274:28466-28475. 1999
Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappa B, and DNA by a designed DNA-binding ligand. 274:12765-12773. 1999
Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase. 274:27711-27716. 1999
L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding. 274:7913-7922. 1999
Macromolecular substrate affinity for the tissue factor-factor viia complex is independent of scissile bond docking. 274:24171-24175. 1999
Major anticodon-binding region missing from an archaebacterial tRNA synthetase. 274:35601-35606. 1999
Mechanisms and consequences of affinity modulation of integrin alpha(v)beta(3) detected with a novel patch-engineered monovalent ligand. 274:21609-21616. 1999
Mekk3 directly regulates mek5 activity as part of the big mitogen-activated protein kinase 1 (bmk1) signaling pathway. 274:36035-36038. 1999
Molecular genetics of transmissible spongiform encephalopathies. 274:3-6. 1999
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase. 274:24100-24112. 1999
Nf-kappa b activity is induced by neural cell adhesion molecule binding to neurons and astrocytes. 274:2432-2439. 1999
Nmr structure and metal interactions of the copz copper chaperone. 274:22597-22603. 1999
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. 274:6718-6725. 1999
Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (hiv-1). 274:4115-4123. 1999
Protein crystallization on lipid layers and structure determination of the RNA polymerase II transcription initiation complex. 274:6813-6816. 1999
RNA determinants for translational editing. Mischarging a minihelix substrate by a tRNA synthetase. 274:6835-6838. 1999
Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains. 274:24074-24079. 1999
Shared and unique determinants of the erythropoietin (epo) receptor are important for binding epo and epo mimetic peptide. 274:14163-14169. 1999
Species barrier to RNA recognition overcome with nonspecific RNA binding domains. 274:16508-16512. 1999
The cooh terminus of aminoglycoside phosphotransferase (3 ')-iiia is critical for antibiotic recognition and resistance. 274:30697-30706. 1999
The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. 274:30799-30810. 1999
The prespore vesicles of dictyostelium discoideum - purification, characterization, and developmental regulation. 274:35823-35831. 1999
The retinal rod Na+/Ca2+,K+ exchanger contains a noncleaved signal sequence required for translocation of the N terminus. 274:38177-38182. 1999
Tropomodulin increases the critical concentration of barbed end-capped actin filaments by converting ADP.P(i)-actin to ADP-actin at all pointed filament ends. 274:34637-34645. 1999
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition. 274:26907-26911. 1999
Unique regulation of immediate early gene and tyrosine hydroxylase expression in the odor-deprived mouse olfactory bulb. 274:3042-3047. 1999
A novel calmodulin-regulated Ca2+-ATPase (ACA2) from Arabidopsis with an N-terminal autoinhibitory domain. 273:1099-1106. 1998
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47(PHOX) on serine 303 or 304. 273:9539-9543. 1998
Involvement of an active-site Zn2+ ligand mechanism of human glyoxalase I. 273:21623-21628. 1998
Structure of cysteine- and glycine-rich protein CRP2. Backbone dynamics reveal motional freedom and independent spatial orientation of the lim domains. 273:23233-23240. 1998
Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1. 273:26218-26224. 1998
When size is important - Accommodation of magnesium in a calcium binding regulatory domain. 273:28994-29001. 1998
A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding. 273:27988-27997. 1998
A minimally lipidated form of cell-derived apolipoprotein e exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins. 273:4206-4212. 1998
A second mammalian n-myristoyltransferase. 273:6595-6598. 1998
A t14c variant of azotobacter vinelandii ferredoxin i undergoes facile 3fe-4s degrees to 4fe-4s (2+) conversion in vitro but not in vivo. 273:33692-33701. 1998
Adenosine 5 '-phosphosulfate kinase from Penicillium chrysogenum - site-directed mutagenesis at putative phosphoryl-accepting and ATP P-loop residues. 273:28583-28589. 1998
All four homochiral enantiomers of a nuclear localization sequence derived from c-Myc serve as functional import signals. 273:29764-29769. 1998
Autoactivation of avian urokinase-type plasminogen activator (upa) - a novel mode of initiation of the upa/plasmin cascade. 273:7457-7461. 1998
Binding of bacterial peptidoglycan to cd14. 273:8680-8690. 1998
Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va. 273:14900-14905. 1998
Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation. 273:1880-1887. 1998
Cloning and expression in escherichia coli of the cytochrome c(552) gene from thermus thermophilus hb8 - evidence for genetic linkage to an atp-binding cassette protein and initial characterization of the cyca gene products. 273:12006-12016. 1998
Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. 273:27484-27491. 1998
Cyclin d3 is rate-limiting for the g(1)/s phase transition in fibroblasts. 273:14958-14961. 1998
Domain swapping in inducible nitric-oxide synthase - electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer. 273:18950-18958. 1998
Evidence of viral capsid dynamics using limited proteolysis and mass spectrometry. 273:673-676. 1998
Gene expression in scrapie - cloning a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. 273:7691-7697. 1998
Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa. 273:23764-23772. 1998
Interaction between apob and hepatic lipase mediates the uptake of apob-containing lipoproteins. 273:20456-20462. 1998
Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappa B. 273:27467-27473. 1998
Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants. 273:24583-24591. 1998
Molecular role for the Rab binding platform of guanine nucleotide dissociation inhibitor in endoplasmic reticulum to Golgi transport. 273:26931-26938. 1998
Mutation of the sialyltransferase s-sialylmotif alters the kinetics of the donor and acceptor substrates. 273:9608-9614. 1998
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1. 273:27154-27161. 1998
Phosphorylation of the spo0b response regulator phosphotransferase of the phosphorelay initiating development in bacillus subtilis. 273:23849-23855. 1998
Role of the STAT1-SH2 domain and STATE in the activation and nuclear translocation of STAT1. 273:30073-30076. 1998
Spectinomycin kinase from legionella pneumophila - characterization of substrate specificity and identification of catalytically important residues. 273:14788-14795. 1998
Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria. 273:16962-16967. 1998
Subdomain chimeras of hepatic lipase and lipoprotein lipase - localization of heparin and cofactor binding. 273:30979-30984. 1998
The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant. 273:23055-23061. 1998
The hydrophobic face orientation of apolipoprotein a-i amphipathic helix domain 143-164 regulates lecithin : Cholesterol acyltransferase activation. 273:11776-11782. 1998
The major nuclear envelope targeting domain of lap2 coincides with its lamin binding region but is distinct from its chromatin interaction domain. 273:4213-4219. 1998
The nh2-terminal region of apolipoprotein b is sufficient for lipoprotein association with glycosaminoglycans. 273:35355-35361. 1998
Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. 273:26559-26565. 1998
Antibody humanization using monovalent phage display. 272:10678-10684. 1997
Characterization of UT2 cells. The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 272:24579-24587. 1997
Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains. 272:2429-2436. 1997
Human class mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome. 272:5727-5731. 1997
MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. 272:31589-31597. 1997
Solution structure of the carboxyl-terminal LIM domain from quail cysteine-rich protein CRP2. 272:12001-12007. 1997
The conserved N-capping box in the hydrophobic core of glutathione S-transferase P1-1 is essential for refolding - Identification of a buried and conserved hydrogen bond important for protein stability. 272:25518-25523. 1997
A Rab GTPase is required for homotypic assembly of the endoplasmic reticulum. 272:13479-13483. 1997
Active site modification of factor viia affects interactions of the protease domain with tissue factor. 272:19875-19879. 1997
Alteration in apolipoprotein a-i 22-mer repeat order results in a decrease in lecithin:Cholesterol acyltransferase reactivity. 272:7278-7284. 1997
C-src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1 (bmk1). 272:20389-20394. 1997
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. 272:29207-29211. 1997
Ca2+ binding to the first epidermal growth factor module of coagulation factor viia is important for cofactor interaction and proteolytic function. 272:17467-17472. 1997
Cellular binding of soluble cd14 requires lipopolysaccharide (lps) and lps-binding protein. 272:23157-23164. 1997
Characterization of a novel iodocyanopindolol and sm-11044 binding protein, which may mediate relaxation of depolarized rat colon tonus. 272:21244-21252. 1997
Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. 272:17070-17077. 1997
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38 delta. 272:30122-30128. 1997
Controlling amyloid beta-peptide fibril formation with protease-stable ligands. 272:12601-12605. 1997
Expression and purification of the saccharomyces cerevisiae alpha-factor receptor (ste2p), a 7-transmembrane-segment g protein-coupled receptor. 272:15553-15561. 1997
G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 272:25425-25428. 1997
Generation of alzheimer amyloid beta peptide through nonspecific proteolysis. 272:1870-1875. 1997
HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5. 272:6854-6857. 1997
High levels of the gtpase ran/tc4 relieve the requirement for nuclear protein transport factor 2. 272:21534-21539. 1997
Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant. 272:22809-22816. 1997
Identification of a novel protein kinase A anchoring protein that binds both type l and type ll regulatory subunits. 272:8057-8064. 1997
Identification of a region in the integrin beta 3 subunit that confers ligand binding specificity. 272:23912-23920. 1997
In vivo regulation of crkii and crkl proto-oncogenes in the uterus by insulin-like growth factor-i - differential effects on tyrosine phosphorylation and association with paxillin. 272:27660-27664. 1997
Induction of interferon-gamma inducing factor in the adrenal cortex. 272:2035-2037. 1997
Lipopolysaccharide (lps)-binding proteins bpi and lbp form different types of complexes with lps. 272:18682-18685. 1997
Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - regulation by egr-1, c-jun, and nf-kappa b transcription factors. 272:17795-17801. 1997
Lipoxin A(4) stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A(4) receptor. 272:6972-6978. 1997
Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins. 272:29127-29136. 1997
Matrix-assisted laser desorption ionization/quadrupole ion trap mass spectrometry of peptides. Application to the localization of phosphorylation sites on the P protein from Sendai virus. 272:1735-1741. 1997
Molecular determinants of Arg-Gly-Asp ligand specificity for beta(3) integrins. 272:4103-4107. 1997
Nmr spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2 - the carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein. 272:18038-18043. 1997
Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis. 272:2834-2840. 1997
Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast. 272:17873-17879. 1997
Regulation of Schizosaccharomyces pombe Wee1 tyrosine kinase. 272:13320-13325. 1997
Structure-function studies of p38 mitogen-activated protein kinase - loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection. 272:11096-11102. 1997
Structure/function relationship of the cAMP response element in tyrosine hydroxylase gene transcription. 272:19158-19164. 1997
The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells. 272:20332-20335. 1997
The proton-translocating nadh-quinone oxidoreductase (ndh-1) of thermophilic bacterium thermus thermophilus hb-8 - complete DNA sequence of the gene cluster and thermostable properties of the expressed nq02 subunit. 272:4201-4211. 1997
Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway. Catecholamine storage vesicles as a reservoir for the rapid release of t-PA. 272:1976-1982. 1997
Y13c azotobacter vinelandii ferredoxin i - a designed fe-s ligand motif contains a cysteine persulfide. 272:15620-15627. 1997
pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe. 272:12100-12106. 1997
Molecular cloning, heterologous expression, and characterization of human glyoxalase II. 271:319-323. 1996
Selection of linkers for a catalytic single-chain antibody using phage display technology. 271:15682-15686. 1996
A cytolytic function for a sialic acid-binding lectin that is a member of the pentraxin family of proteins. 271:14717-14721. 1996
A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. 271:7986-7991. 1996
An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. 271:17152-17156. 1996
An allosteric ca2+ binding site on the beta 3 integrins that regulates the dissociation rate for rgd ligands. 271:21745-21751. 1996
Arrest of beta-amyloid fibril formation by a pentapeptide ligand. 271:8545-8548. 1996
Big mitogen-activated protein kinase 1 (bmk1) is a redox-sensitive kinase. 271:16586-16590. 1996
Binding of viral antigens to major histocompatibility complex class i h-2d(b) molecules is controlled by dominant negative elements at peptide non-anchor residues - implications for peptide selection and presentation. 271:17829-17836. 1996
Characterization of the structure and function of a novel map kinase kinase (mkk6). 271:2886-2891. 1996
Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibα. 271:9046-9053. 1996
Differential regulation of vitronectin in mice and humans in vitro. 271:5474-5480. 1996
Direct association between the yeast rad51 and rad54 recombination proteins. 271:33181-33186. 1996
Down-regulation of beta(3) adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor. 271:33366-33375. 1996
Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. 271:9455-9459. 1996
Dynamin self-assembly stimulates its gtpase activity. 271:22310-22314. 1996
Effector cell protease receptor-1 is a vascular receptor for coagulation factor xa. 271:28407-28413. 1996
Enhancement of protein kinase C-dependent O2 (bar dot) production in Epstein-Barr virus-transformed B lymphocytes by p120(Ras-GAP) antisense oligonucleotide. 271:9320-9325. 1996
Expression and characterization of the flavoprotein subcomplex composed of 50-kda (nqo1) and 25-kda (nqo2) subunits of the proton-translocating nadh-quinone oxidoreductase of paracoccus denitrificans. 271:5907-5913. 1996
Expression and immunoaffinity purification of human inducible nitric-oxide synthase - inhibition studies with 2-amino-5,6-dihydro-4H-1,3-thiazine. 271:28212-28219. 1996
Genomic organization and chromosomal mapping of the gal beta 1,3galnac/gal beta 1,4glcnac alpha 2,3-sialyltransferase. 271:931-938. 1996
Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues. 271:14526-14532. 1996
Identification and characterization of the cytoplasmic antiproteinase (cap) in human platelets - evidence for the interaction of cap with endogenous platelet proteins. 271:7160-7167. 1996
Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A(2) expressed in insect cells and present in human monocytes. 271:6987-6997. 1996
Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis. 271:25375-25381. 1996
Mammalian Sly1 regulates syntaxin 5 function in endoplasmic reticulum to Golgi transport. 271:15866-15869. 1996
Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family. 271:20238-20241. 1996
Molecular cloning of a developmentally regulated n-acetylgalactosamine alpha 2,6-sialyltransferase specific for sialylated glycoconjugates. 271:7450-7459. 1996
New molecular and structural determinants involved in beta(2)-adrenergic receptor desensitization and sequestration - delineation using chimeric beta(3)/beta(2)-adrenergic receptors. 271:9355-9362. 1996
Purification of storage granule protein-23 - a novel protein identified by phage display technology and interaction with type 1 plasminogen activator inhibitor. 271:30126-30135. 1996
Rab2 is essential for the maturation of pre-Golgi intermediates. 271:29372-29379. 1996
Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca(2+)/calmodulin-dependent protein kinases type I, II, and IV. 271:3066-3073. 1996
Regulation of plasminogen receptor expression on monocytoid cells by beta1-integrin-dependent cellular adherence to extracellular matrix proteins. 271:23761-23767. 1996
Replacement of Trp(28) in Escherichia coli thioredoxin by site-directed mutagenesis affects thermodynamic stability but not function. 271:3091-3096. 1996
Role of beta 3 integrins in melanoma cell adhesion to activated platelets under flow. 271:5892-5900. 1996
Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin. 271:12716-12723. 1996
Type 1 plasminogen activator inhibitor induces multimerization of plasma vitronectin. A suggested mechanism for the generation of the tissue form of vitronectin in vivo. 271:29644-29651. 1996
Cloning, sequencing, and regulation of the glutathione reductase gene from the cyanobacterium Anabaena PCC 7120. 270:22882-22889. 1995
The cysteine-rich protein family of highly related LIM domain proteins. 270:28946-28954. 1995
The high activity of rat glutathione transferase 8-8 with alkene substrates is dependent on a glycine residue in the active site. 270:29705-29709. 1995
A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway. 270:19989-19997. 1995
Active-site and oligosaccharide recognition residues of peptide-n-4-(n-acetyl-beta-d-glucosaminyl)asparagine amidase-f. 270:29493-29497. 1995
Alpha(2)-macroglobulin-mediated clearance of proteases from the plasma of the american horseshoe-crab, limulus-polyphemus. 270:13496-13502. 1995
An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation. 270:7041-7044. 1995
Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera. 270:11502-11513. 1995
Calmodulin stabilizes an amphiphilic alpha-helix within rc3/neurogranin and gap-43/neuromodulin only when ca2+ is absent. 270:6741-6750. 1995
Cdna cloning and characterization of lamina-associated polypeptide 1c (lap1c), an integral protein of the inner nuclear-membrane. 270:8822-8828. 1995
Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets. 270:23352-23361. 1995
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. 270:18929-18934. 1995
Expression and characterization of the 66-kilodalton (nqo3) iron-sulfur subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus-denitrificans. 270:18264-18270. 1995
Homology dependence of uvsx protein-catalyzed joint molecule formation. 270:5181-5186. 1995
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding. 270:9571-9578. 1995
Incorporation of d-alanine into lipoteichoic acid and wall teichoic-acid in bacillus-subtilis - identification of genes and regulation. 270:15598-15606. 1995
Interaction of integrin alpha(IIb)beta(3) with multiple fibrinogen domains during platelet adhesion. 270:28812-28817. 1995
Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. 270:27932-27936. 1995
Lipopolysaccharide (lps) signal-transduction and clearance - dual roles for lps binding-protein and membrane cd14. 270:5320-5325. 1995
Lipopolysaccharide-binding protein-mediated complexation of lipopolysaccharide with soluble cd14. 270:10482-10488. 1995
Lipoprotein-lipase association with lipoproteins involves protein-protein interaction with apolipoprotein-b. 270:8081-8086. 1995
Localization of the disulfide bond involved in post-translational processing of glycosylasparaginase and disrupted by a mutation in the Finnish-type aspartylglycosaminuria. 270:3212-3215. 1995
Long-term phorbol ester treatment down-regulates the beta(3)-adrenergic receptor in 3t3-f442a adipocytes. 270:10952-10959. 1995
Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. 270:5872-5876. 1995
Molecular-cloning of bomapin (protease-inhibitor-10), a novel human serpin that is expressed specifically in the bone-marrow. 270:26754-26757. 1995
Molecular-genetic and protein chemical characterization of the cytochrome ba(3) from thermus-thermophilus hb8. 270:20345-20358. 1995
Novel sequence determinants in peroxisome proliferator signaling. 270:16114-16121. 1995
Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway. 270:14928-14934. 1995
Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in monocytes. Correlation with an increased kappa B binding activity. 270:7787-7790. 1995
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. 270:7420-7426. 1995
Radicicol, a protein-tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis. 270:5418-5426. 1995
Rho-family gtpases regulate p38 mitogen-activated protein-kinase through the downstream mediator pak1. 270:23934-23936. 1995
Ricin cytotoxicity is sensitive to recycling between the endoplasmic-reticulum and the Golgi-complex. 270:20078-20083. 1995
Silencer elements modulate the expression of the gene for the neuron-glia cell-adhesion molecule, ng-cam. 270:21291-21298. 1995
The activation state of the integrin alpha(IIb)beta(3) affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation. 270:18133-18140. 1995
The retinoblastoma susceptibility gene-product represses transcription when directly bound to the promoter. 270:8837-8843. 1995
The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8 receptor type A. 270:10428-10431. 1995
The sialyltransferase sialylmotif participates in binding the donor substrate cmp-neuac. 270:1497-1500. 1995
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta(3) subunit. 270:11947-11954. 1995
Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites. 270:24216-24221. 1995
Active site mutants of Escherichia coli citrate synthase. Effects of mutations on catalytic and allosteric properties. 269:412-417. 1994
Cloning and analysis of a constitutive heat shock (cognate) protein 70 gene inducible by L-glutamine. 269:4513-4522. 1994
Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. 269:760-764. 1994
A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45. 269:2535-2540. 1994
Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v. 269:23937-23943. 1994
Alternative splicing of the nc1 domain of the human-alpha-3(iv) collagen gene - differential expression of messenger-rna transcripts that predict 3 protein variants with distinct carboxyl regions. 269:2342-2348. 1994
An amino-terminal fragment of apolipoprotein-b binds to lipoprotein-lipase and may facilitate its binding to endothelial-cells. 269:9409-9412. 1994
Azotobacter-vinelandii ferredoxin-i - alteration of individual surface-charges and the 4fe-4s (2+/+) cluster reduction potential. 269:8564-8575. 1994
Binding and activation of the promoter for the neural cell-adhesion molecule by pax-8. 269:22245-22252. 1994
Building synthetic antibodies as adhesive ligands for integrins. 269:32788-32795. 1994
Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid residue. 269:13680-13684. 1994
Cell-specific down-regulation of the beta(3)-adrenergic receptor. 269:13148-13155. 1994
Cellular differences in lipoprotein lipase-mediated uptake of low-density lipoproteins. 269:13129-13135. 1994
Cloning of a novel alpha-2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. 269:1394-1401. 1994
Cloning, expression, and characterization of human apolipoprotein(a) kringle iv37. 269:21820-21827. 1994
Differential expression of 5 sialyltransferase genes in human tissues. 269:17872-17878. 1994
Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides. 269:326-331. 1994
Dominant inhibitory mutants of arf1 block endoplasmic-reticulum to golgi transport and trigger disassembly of the golgi-apparatus. 269:1437-1448. 1994
Endothelin induces tyrosine phosphorylation and grb2 association of shc in astrocytes. 269:24805-24809. 1994
Export of protein from the endoplasmic-reticulum is regulated by a diacylglycerol phorbol ester binding-protein. 269:26848-26857. 1994
Expression of human apolipoprotein b90 in transgenic mice - demonstration that apolipoprotein b90 laces the structural requirements to form lipoprotein(a). 269:24284-24289. 1994
High molecular-weight kininogen binds to mac-1 on neutrophils by its heavy-chain (domain-3) and its light-chain (domain-5). 269:19307-19312. 1994
Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation. 269:30049-30055. 1994
Human neutrophil phagocytic granules contain a truncated soluble form of the alzheimer beta/a4 amyloid precursor protein (app). 269:9805-9810. 1994
Identification of a novel integrin binding-site in fibronectin - differential utilization by beta-3 integrins. 269:10856-10863. 1994
Identification of a p53 binding-site in the human retinoblastoma susceptibility gene promoter. 269:6383-6389. 1994
Identification of a regulatory domain of the interleukin-6 receptor. 269:20791-20797. 1994
Inhibition of calcineurin by a novel fk-506-binding protein. 269:21094-21102. 1994
Interaction of the peroxisome proliferator-activated receptor-alpha with the retinoid-X receptor-alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter. 269:18083-18089. 1994
Interactions of active-site residues and catalytic activity of human carbonic anhydrase III. 269:23002-23006. 1994
Intercellular-adhesion molecule-1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial-cells. 269:12536-12540. 1994
Interleukin-1-beta regulates human cytotrophoblast metalloproteinase activity and invasion in-vitro. 269:17125-17131. 1994
Isoform-specific interaction of tropomodulin with skeletal muscle and erythrocyte tropomyosins. 269:27510-27518. 1994
Key ligand interface residues in tissue factor contribute independently to factor viia binding. 269:19399-19403. 1994
Lipopolysaccharide (lps) binding-protein, truncated at ile-197, binds lps but does not transfer lps to cd14. 269:8172-8175. 1994
Lipopolysaccharide binding protein expression in primary human hepatocytes and HepG2 hepatoma cells. 269:8477-8482. 1994
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. 269:6478-6484. 1994
Localization of an apolipoprotein-a-i epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells. 269:10288-10297. 1994
Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man. 269:27996-27999. 1994
Microfilament reorganization is associated with functional activation of alpha(m)beta(2) on monocytic cells. 269:3159-3166. 1994
Mutational and biophysical studies suggest rc3/neurogranin regulates calmodulin availability. 269:22420-22426. 1994
P145, a major grb2-binding protein in brain, is co-localized with dynamin in nerve-terminals where it undergoes activity-dependent dephosphorylation. 269:30132-30139. 1994
Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes. 269:25735-25741. 1994
Properties of the iron-sulfur center in the 25-kilodalton subunit of the proton-translocating nadh-quinone oxidoreductase of paracoccus-denitrificans. 269:21030-21036. 1994
Species-difference in the g-protein selectivity of the human and bovine a(1)-adenosine receptor. 269:32077-32084. 1994
Structure, distribution, and functional expression of the phosphofructokinase-c isozyme. 269:3348-3355. 1994
Subunit composition and domain-structure of the spo0a sporulation transcription factor of bacillus-subtilis. 269:16977-16982. 1994
Sulfated blood-group lewis(a) - a superior oligosaccharide ligand for human e-selectin. 269:1595-1598. 1994
Syntaxin-5 regulates endoplasmic-reticulum to golgi transport. 269:29363-29366. 1994
Synthetic compound peptide simulating antigenicity of conformation-dependent autoepitope. 269:18529-18534. 1994
The amino-terminus of the human c5a receptor is required for high-affinity c5a binding and for receptor activation by c5a but not c5a analogs. 269:14446-14450. 1994
The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product. 269:6083-6088. 1994
The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. 269:26691-26696. 1994
The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor. 269:2659-2666. 1994
Transcriptional modulation by n-butyric acid of beta-1-adrenergic, beta-2-adrenergic, and beta-3-adrenergic receptor balance in 3t3-p442a adipocytes. 269:6664-6670. 1994
Triple hydroxylation of tetracenomycin-a2 to tetracenomycin-c in streptomyces-glaucescens - overexpression of the tcmg gene in streptomyces-lividans and characterization of the tetracenomycin-a2 oxygenase. 269:30726-30733. 1994
Tubulin gtp hydrolysis influences the structure, mechanical-properties, and kinesin driven transport of microtubules. 269:23769-23775. 1994
Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation. 269:19836-19842. 1994
Zinc-dependent cell growth conferred by mutant tRNA synthetase. 269:20217-20220. 1994
Zinc-free and reduced t4 gene-32 protein binds single-stranded-DNA weakly and fails to stimulate uvsx-catalyzed homologous pairing. 269:2773-2781. 1994
ntf1+ encodes a 6-cysteine zinc finger-containing transcription factor that regulates the nmt1 promoter in fission yeast. 269:11921-11926. 1994
Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants. 268:12185-12192. 1993
Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. 268:22299-22304. 1993
A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3. 268:6939-6944. 1993
Analysis of lipopolysaccharide-binding by cd14. 268:24818-24823. 1993
Azotobacter-vinelandii ferredoxin-i - aspartate-15 facilitates proton-transfer to the reduced 3fe-4s cluster. 268:25928-25939. 1993
Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. 268:2872-2877. 1993
Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2. 268:21997-22003. 1993
Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa. 268:21080-21087. 1993
Crystal-structures of oxidized and reduced azotobacter-vinelandii ferredoxin at ph-8 and ph-6. 268:25920-25927. 1993
Cytochrome-oxidase genes from thermus-thermophilus - nucleotide-sequence of the fused gene and analysis of the deduced primary structures for subunit-i and subunit-iii of cytochrome-caa3. 268:5395-5408. 1993
Differential inhibition of multiple vesicular transport steps between the endoplasmic-reticulum and trans-golgi network. 268:4216-4226. 1993
Disulfide bond requirements for assembly of the platelet glycoprotein Ib-binding domain of von Willebrand factor. 268:2821-2827. 1993
Endotoxin induces rapid protein-tyrosine phosphorylation in 70z/3 cells expressing cd14. 268:25009-25014. 1993
Expression of human platelet glycoprotein Ib alpha in transgenic mice. 268:8376-8382. 1993
How do "Zn2 cys6" proteins distinguish between similar upstream activation sites? Comparison of the DNA-binding specificity of the GAL4 protein in vitro and in vivo. 268:24699-24706. 1993
Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein. 268:16788-16794. 1993
Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. 268:21527-21532. 1993
Ligand-induced internalization of the epidermal growth-factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. 268:19312-19320. 1993
Microhelix aminoacylation by a class I tRNA synthetase. Non-conserved base pairs required for specificity. 268:6069-6072. 1993
Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. 268:18167-18175. 1993
Nitric oxide synthase structure and mechanism. 268:12231-12234. 1993
Oligomerization of immunoglobulin-g heavy and light-chains in vitro - a cell-free assay to study the assembly of the endoplasmic-reticulum. 268:5182-5192. 1993
Outside and downstream of the homeobox. 268:20683-20686. 1993
Polymerase chain-reaction cloning of a developmentally-regulated member of the sialyltransferase gene family. 268:11504-11507. 1993
Purification of glutamine tRNA synthetase from Saccharomyces cerevisiae. A monomeric aminoacyl-tRNA synthetase with a large and dispensable NH2-terminal domain. 268:5519-5523. 1993
Regulation of alpha-2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (pna)+ to pna- phenotype in developing thymocytes. 268:3801-3804. 1993
The role of protein-protein interactions in the assembly of the presynaptic filament for t4 homologous recombination. 268:7904-7911. 1993
A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3. 267:18085-18092. 1992
A synthetic sialic-acid analog is recognized by influenza-c virus as a receptor determinant but is resistant to the receptor-destroying enzyme. 267:12501-12505. 1992
Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor. 267:19757-19760. 1992
Adp-ribosylation factor is required for vesicular trafficking between the endoplasmic-reticulum and the cis-golgi compartment. 267:13053-13061. 1992
Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. 267:2775-2785. 1992
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. 267:546-554. 1992
Assembly and expression of an intrinsic factor-IX activator complex on the surface of cultured human endothelial-cells. 267:19833-19839. 1992
Characterization and nucleotide binding-properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement. 267:15334-15339. 1992
Cloning and expression of the gal-beta-1,3galnac alpha-2,3-sialyltransferase. 267:21004-21010. 1992
Cofactor residues lysine-165 and lysine-166 are critical for protein substrate recognition by the tissue factor-factor-viia protease complex. 267:6375-6381. 1992
Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments. 267:5070-5077. 1992
Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase. 267:15563-15567. 1992
Functional expression of the human serotonin 5-ht1a receptor in escherichia-coli - ligand-binding properties and interaction with recombinant g-protein alpha-subunits. 267:8200-8206. 1992
Induction of cyclin messenger-rna and cyclin-associated histone-h1 kinase during liver-regeneration. 267:2841-2844. 1992
Inhibition by dexamethasone of beta-3-adrenergic receptor responsiveness in 3t3-f442a adipocytes - evidence for a transcriptional mechanism. 267:15909-15915. 1992
Interaction of xenopus TFIIIC with the TFIIIA.5-S RNA gene-complex. 267:18190-18198. 1992
Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. 267:11300-11306. 1992
Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein. 267:2616-2621. 1992
Primary structure of gal-beta-1,3(4)glcnac alpha-2,3-sialyltransferase determined by mass-spectrometry sequence-analysis and molecular-cloning - evidence for a protein motif in the sialyltransferase gene family. 267:21011-21019. 1992
Regulated expression of alpha-2,6-sialyltransferase by the liver-enriched transcription factors hnf-1, dbp, and lap. 267:3466-3472. 1992
Role of the membrane-surface in the activation of human coagulation factor-x. 267:26110-26120. 1992
The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome-P450 fatty-acid omega-hydroxylase, by clofibric acid. 267:19051-19053. 1992
The signal anchor and stem regions of the beta-galactoside alpha-2,6-sialyltransferase may each act to localize the enzyme to the golgi-apparatus. 267:7784-7793. 1992
Tissue factor residues 157-167 are required for efficient proteolytic activation of factor-x and factor-vii. 267:22206-22210. 1992
Tissue-specific alternative splicing of the beta-galactoside alpha-2,6-sialyltransferase gene. 267:2512-2518. 1992
Transactivation of the c-myc promoter by human t-cell leukemia-virus type-1 tax is mediated by nf-kappa-b. 267:16288-16291. 1992
Tripartite functional assembly of a large class I aminoacyl tRNA synthetase. 267:22703-22706. 1992
The role of cysteine 206 in allosteric inhibition of Escherichia coli citrate synthase. Studies by chemical modification, site-directed mutagenesis, and 19-F NMR. 266:20709-20713. 1991
Yeast expression of a catalytic antibody with chorismate mutase activity. 266:11901-11908. 1991
A 28,000-Da GDP/GTP-binding protein specific to the nuclear envelope. 266:7602-7608. 1991
A synthetic peptide mimic of plasma apolipoprotein-e that binds the ldl receptor. 266:22803-22806. 1991
Aminoacylation of alanine minihelices. "Discriminator" base modulates transition state of single turnover reaction. 266:2705-2708. 1991
An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5. 266:6215-6220. 1991
Atypical beta-adrenergic-receptor in 3t3-f442a adipocytes pharmacological and molecular relationship with the human beta-3-adrenergic receptor. 266:20329-20336. 1991
C-13 NMR evidence that substitution of glutamine for arginine-3500 in familial defective apolipoprotein-b-100 disrupts the conformation of the receptor-binding domain. 266:2701-2704. 1991
Characterization of factor-vii association with tissue factor in solution - high and low affinity calcium-binding sites in factor-vii contribute to functionally distinct interactions. 266:15719-15725. 1991
Contacts between 5S DNA and Xenopus TFIIIA identified using 5-azido-2'-deoxyuridine-substituted DNA. 266:16478-16484. 1991
Crystallographic analysis of 2 site-directed mutants of azotobacter-vinelandii ferredoxin. 266:21558-21562. 1991
Cytochrome-oxidase genes from thermus-thermophilus - nucleotide-sequence and analysis of the deduced primary structure of subunit-iic of cytochrome-caa3. 266:5025-5035. 1991
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c. 266:13431-13441. 1991
Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. 266:2824-2830. 1991
Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin. 266:23776-23783. 1991
Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline. 266:5860-5869. 1991
Identification of a sequence of human activated protein-C (residues 390-404) essential for its anticoagulant activity. 266:24514-24519. 1991
Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib. 266:18172-18178. 1991
Identification of divalent metal ion-dependent inhibition of activated protein-C by alpha-2-macroglobulin and alpha-2-antiplasmin in blood and comparisons to inhibition of factor-Xa, thrombin, and plasmin. 266:17606-17612. 1991
Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta. 266:23048-23052. 1991
Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site. 266:12342-12347. 1991
Inhibition of protein-mediated homologous pairing by a DNA helicase. 266:9712-9718. 1991
Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA). 266:2017-2020. 1991
Isolation and characterization of a 70-kda metalloprotease (gelatinase) that is elevated in rous-sarcoma virus-transformed chicken-embryo fibroblasts. 266:5113-5121. 1991
Localization of an apolipoprotein-a-i epitope critical for activation of lecithin-cholesterol acyltransferase. 266:23886-23892. 1991
Mapping apolipoprotein-b on the low-density-lipoprotein surface by immunoelectron microscopy. 266:5955-5962. 1991
Only multimers of a synthetic peptide of human apolipoprotein-e are biologically-active. 266:15009-15015. 1991
Phospholipid-independent and phospholipid-dependent interactions required for tissue factor receptor and cofactor function. 266:2158-2166. 1991
Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. 266:22789-22791. 1991
Reaction of proteinases with alpha-2-macroglobulin from the american horseshoe-crab, limulus. 266:19426-19431. 1991
Resonance raman and electron-paramagnetic resonance structural investigations of neutrophil cytochrome-b558. 266:1627-1634. 1991
SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells. 266:13178-13184. 1991
Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. 266:11227-11233. 1991
Sequential transport of protein between the endoplasmic-reticulum and successive golgi compartments in semi-intact cells. 266:13055-13063. 1991
Site-directed mutagenesis of a soluble recombinant fragment of platelet glycoprotein Ib alpha demonstrating negatively charged residues involved in von Willebrand factor binding. 266:15474-15480. 1991
Structural relationships and the classification of aminoacyl-tRNA synthetases. 266:16965-16968. 1991
Structure of alpha-2-macroglobulin from the arthropod limulus-polyphemus. 266:2526-2530. 1991
Tandem mass-spectrometry identifies sites of 3 posttranslational modifications of spinach light-harvesting chlorophyll protein-II - proteolytic cleavage, acetylation, and phosphorylation. 266:17584-17591. 1991
The integrity of the cysteine-186-cysteine-209 bond of the 2nd disulfide loop of tissue factor is required for binding of factor-vii. 266:10294-10299. 1991
The transition-state regulator hpr of bacillus-subtilis is a DNA-binding protein. 266:13411-13417. 1991
Urinary protein-C inhibitor - glycosaminoglycans synthesized by the epithelial kidney-cell line TCL-598 enhance its interaction with urokinase. 266:11851-11857. 1991
Use of in vitro protein-synthesis from polymerase chain reaction-generated templates to study interaction of Escherichia-coli transcription factors with core RNA-polymerase and for epitope mapping of monoclonal-antibodies. 266:2632-2638. 1991
Crystallization and characterization of Chromatium vinosum cytochrome c'. 265:5364-5365. 1990
A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters. 265:1005-1009. 1990
A single-stranded nucleic-acid binding sequence common to the heterogeneous nuclear ribonucleoparticle protein-a1 and murine recombinant virus gp70. 265:3674-3678. 1990
A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin mac-1 (cd11b cd18). 265:12119-12122. 1990
Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function. 265:11766-11772. 1990
Biochemical purification and crystallographic characterization of the fiber-forming protein pilin from Neisseria-gonorrhoeae. 265:2278-2285. 1990
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide-dismutase mutant resulting from the removal of a buried cysteine. 265:14234-14241. 1990
Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5. 265:14662-14668. 1990
Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of salmonella-typhimurium. 265:12462-12466. 1990
Deletions in the large (beta) subunit of a hetero-oligomeric aminoacyl-tRNA synthetase. 265:1000-1004. 1990
Differential regulation of beta-1-adrenergic and beta-2-adrenergic receptor protein and messenger-rna levels by glucocorticoids during 3t3-f442a adipose differentiation. 265:16343-16349. 1990
Diffraction quality crystals of lysin from spermatozoa of the red abalone (haliotis-rufescens). 265:4958-4961. 1990
Highly sulfated glycosaminoglycans augment the cross-linking of vitronectin by guinea pig liver transglutaminase. Functional studies of the cross-linked vitronectin multimers. 265:3543-3548. 1990
Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding. 265:274-280. 1990
Identification of lipopolysaccharide-binding proteins in 70z/3 cells by photoaffinity cross-linking. 265:9520-9525. 1990
Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine-358. 265:2365-2369. 1990
Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. 265:12267-12271. 1990
Metabolism-based covalent bonding of the heme prosthetic group to its apoprotein during the reductive debromination of BrCCl3 by myoglobin. 265:10340-10346. 1990
Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. 265:13415-13418. 1990
Organization of the beta-galactoside alpha-2,6-sialyltransferase gene - evidence for the transcriptional regulation of terminal glycosylation. 265:20863-20868. 1990
Protein-structure determination in solution by NMR-spectroscopy. 265:22059-22062. 1990
Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin-6 and interferon-gamma. 265:12664-12670. 1990
Sequential intermediates in the transport of protein between the endoplasmic-reticulum and the golgi. 265:18298-18310. 1990
Studies on the nadh-menaquinone oxidoreductase segment of the respiratory-chain in thermus-thermophilus hb-8. 265:1360-1368. 1990
The role of the bacteriophage-t4 gene-32 protein in homologous pairing. 265:20966-20969. 1990
Transport and secretion of truncated t-cell receptor beta-chain occurs in the absence of association with cd3. 265:9296-9301. 1990
4-O-acetyl-N-acetylneuraminic acid in the N-linked carbohydrate structures of equine and guinea pig alpha 2-macroglobulins, potent inhibitors of influenza virus infection. 264:9842-9849. 1989
Alteration of terminal glycosylation sequences on n-linked oligosaccharides of chinese-hamster ovary cells by expression of beta-galactoside alpha-2,6-sialyltransferase. 264:13848-13855. 1989
Alternative cleavage of the cachectin tumor necrosis factor propeptide results in a larger, inactive form of secreted protein. 264:16256-16260. 1989
Amino acid sequence analysis of two mouse calbindin-D9k isoforms by tandem mass spectrometry. Protein modification by internal insertion of a single amino acid. 264:6580-6586. 1989
An infrared study of the binding and photodissociation of carbon-monoxide in cytochrome-ba3 from thermus-thermophilus. 264:2405-2408. 1989
Basis for the potent inhibition of influenza-virus infection by equine and guinea-pig alpha-2-macroglobulin. 264:9850-9858. 1989
Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells. 264:5058-5063. 1989
Biochemistry of interorganelle transport - a new frontier in enzymology emerges from versatile in vitro model systems. 264:16965-16968. 1989
Chemical modification of bovine pancreatic trypsin inhibitor for single site coupling of immunogenic peptides for NMR conformational analysis. 264:7882-7888. 1989
Conversion of a golgi-apparatus sialyltransferase to a secretory protein by replacement of the nh2-terminal signal anchor with a signal peptide. 264:17619-17622. 1989
Crystallization and preliminary-x-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high-affinity interleukin-2 receptor. 264:12730-12736. 1989
Genetically engineered polymers of human Cu Zn superoxide-dismutase - biochemistry and serum half-lives. 264:5260-5268. 1989
Glycosyltransferases - structure, localization, and control of cell type-specific glycosylation. 264:17615-17618. 1989
Hydrodynamic, electron-microscopic, and ligand-binding analysis of the epstein-barr virus c3dg receptor (cr-2). 264:20576-20582. 1989
Identification of a lipid-a binding-site in the acute phase reactant lipopolysaccharide binding-protein. 264:10867-10871. 1989
In vitro use of monoclonal-antibodies in Escherichia-coli S-30 extracts to determine the RNA-polymerase sigma-subunit required by a promoter. 264:3794-3798. 1989
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. 264:8520-8528. 1989
Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system. 264:11738-11743. 1989
Introduction of a metal-dependent regulatory switch into an enzyme. 264:3666-3669. 1989
Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites. 264:17361-17367. 1989
Lipopolysaccharide induces hyporesponsiveness to its own action in raw 2647 cells. 264:21951-21956. 1989
Macrophage oxidation of l-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. 264:19654-19658. 1989
Phosphofructokinase isozyme expression during myoblast differentiation. 264:3658-3661. 1989
Post-translational addition of chondroitin sulfate glycosaminoglycans - role of n-linked oligosaccharide addition, trimming, and processing. 264:1779-1786. 1989
Preliminary crystallographic data and primary sequence for anti-peptide fab' b13i2 and its complex with the c-helix peptide from myohemerythrin. 264:15721-15725. 1989
Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase. 264:9703-9706. 1989
Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix. Evidence that the protein is vitronectin. 264:936-939. 1989
Regulation of the rabbit cytochrome-P-450 3C gene - age-dependent expression and transcriptional activation by rifampicin. 264:16222-16228. 1989
Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha. 264:10396-10401. 1989
Sequential receptor cascade for coagulation proteins on monocytes - constitutive biosynthesis and functional prothrombinase activity of a membrane form of factor v-va. 264:2969-2972. 1989
Several gtp-binding proteins, including p21c-h-ras, are preferred substrates of pseudomonas-aeruginosa exoenzyme-s. 264:9004-9008. 1989
The amino-acid sequence of the sex steroid-binding protein of rabbit serum. 264:19066-19075. 1989
The phage-t4 uvsy recombination protein stabilizes presynaptic filaments. 264:16451-16457. 1989
Tissue-specific expression of sialyltransferases. 264:10931-10934. 1989
7-iron ferredoxin revisited. 263:9256-9260. 1988
A family of lipopolysaccharide binding-proteins involved in responses to gram-negative sepsis. 263:13479-13481. 1988
A human-brain glycoprotein related to the mouse-cell adhesion molecule l1. 263:11943-11947. 1988
Apoprotein-e-rich high-density lipoproteins inhibit ovarian androgen synthesis. 263:10965-10973. 1988
Biochemical-characterization of a sulfated phosphoglycoprotein antigen expressed on human small cell lung-carcinoma. 263:806-811. 1988
Characterization of 2 crystal forms of human defensin neutrophil cationic peptide-1, a naturally-occurring antimicrobial peptide of leukocytes. 263:5933-5935. 1988
Crystallization and preliminary-x-ray diffraction studies of a toxic crystal protein from a subspecies of bacillus-thuringiensis. 263:11800-11801. 1988
Crystallization of trimeric recombinant human-tumor necrosis factor (cachectin). 263:12816-12819. 1988
Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. 263:5797-5803. 1988
Evidence for interaction of an aminoacyl transfer RNA synthetase with a region important for the identity of its cognate transfer RNA. 263:16527-16530. 1988
Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746. 263:7500-7505. 1988
Human-melanoma antigen o-acetylated ganglioside-gd3 is recognized by cancer-antennarius lectin. 263:2079-2086. 1988
Identification of the dicyclohexylcarbodiimide-binding subunit of nadh-ubiquinone oxidoreductase (complex-i). 263:16150-16155. 1988
Iron superoxide-dismutase - nucleotide-sequence of the gene from escherichia-coli-k12 and correlations with crystal-structures. 263:1555-1562. 1988
Isolation and functional characterization of the von Willebrand factor-binding domain located between residues His1-Arg293 of the alpha-chain of glycoprotein Ib. 263:18473-18479. 1988
Isolation of a functional human gene for brain creatine kinase. 263:2442-2446. 1988
Kinetic and immunochemical studies of a receptor-like protein that binds aromatic hydrocarbons. 263:5825-5832. 1988
Kinetic-analysis of the ca-2+-dependent, membrane-bound, macrophage phospholipase-a2 and the effects of arachidonic-acid. 263:7506-7513. 1988
Liver (b-type) phosphofructokinase messenger-rna - cloning, structure, and expression. 263:11755-11759. 1988
Localization of 2 epitopes of apolipoprotein-a-i that are exposed on human high-density lipoproteins using monoclonal-antibodies and synthetic peptides. 263:13779-13785. 1988
Lpr t-cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis. 263:3626-3631. 1988
Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. 263:1665-1675. 1988
Novel subunit structure observed for noncooperative hemoglobin from urechis-caupo. 263:3462-3465. 1988
Physiologic inhibition of human activated protein-C by alpha-1-antitrypsin. 263:11613-11616. 1988
Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome-P-450-3C. 263:17672-17677. 1988
Post-golgi apparatus localization and regional expression of rat intestinal sialyltransferase detected by immunoelectron microscopy with polypeptide epitope-purified antibody. 263:6302-6309. 1988
Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide fab and its complex with a synthetic peptide from influenza-virus hemagglutinin. 263:17100-17105. 1988
Rationale for engineering an enzyme by introducing a mutation that compensates for a deletion. 263:18598-18600. 1988
Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. 263:3111-3115. 1988
Solubilization, purification, and characterization of a membrane-bound phospholipase-a2 from the p388d1 macrophage-like cell-line. 263:3079-3085. 1988
Structure of the von Willebrand factor domain interacting with glycoprotein Ib. 263:17901-17904. 1988
The cell-binding domains of plasminogen and their function in plasma. 263:11928-11934. 1988
The mechanism of homologous DNA strand exchange catalyzed by the bacteriophage-t4 uvsx and gene-32 proteins. 263:9427-9436. 1988
The primary structure of the mitochondrial energy-linked nicotinamide nucleotide transhydrogenase deduced from the sequence of cdna clones. 263:2761-2767. 1988
The saturable high-affinity association of factor-x to adp-stimulated monocytes defines a novel function of the mac-1 receptor. 263:7007-7015. 1988
A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728. 262:1734-1739. 1987
Autoactivation of human-plasma prekallikrein. 262:11308-11314. 1987
Characterization of a second gene product related to rabbit cytochrome P-450 1. 262:5918-5923. 1987
Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae. 262:10807-10813. 1987
Differential transcription of Xenopus oocyte and somatic-type 5 S genes in a Xenopus oocyte extract. 262:17100-17110. 1987
Electron-paramagnetic-res characterization of the iron-sulfur clusters in the nadh - ubiquinone oxidoreductase segment of the respiratory-chain in paracoccus-denitrificans. 262:9147-9153. 1987
Evidence for structural heterogeneities and a study of exchange coupling - mossbauer studies of cytochrome c1aa3 from thermus-thermophilus. 262:16328-16332. 1987
Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl-tRNA synthetases. 262:10801-10806. 1987
Identification and purification of a novel Mr 43,000 tropomyosin-binding protein from human erythrocyte membranes. 262:12792-12800. 1987
Identification of the 37-kda protein displaying a variable interaction with the erythroid cell-membrane as glyceraldehyde-3-phosphate dehydrogenase. 262:649-653. 1987
Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3. 262:15813-15816. 1987
Initiation of the extrinsic pathway of coagulation - association of factor-viia with a cell-line expressing tissue factor. 262:9503-9508. 1987
Isolation and characterization of two domains of human von Willebrand factor that interact with fibrillar collagen types I and III. 262:13835-13841. 1987
Lipoprotein b37, a naturally-occurring lipoprotein containing the amino-terminal portion of apolipoprotein b100, does not bind to the apolipoprotein b,e(low density lipoprotein) receptor. 262:16604-16611. 1987
Primary structure of beta-galactoside alpha-2,6-sialyltransferase - conversion of membrane-bound enzyme to soluble forms by cleavage of the nh2-terminal signal anchor. 262:17735-17743. 1987
Proliferating cell nuclear antigen/cyclin is an interleukin 2-responsive gene. 262:8447-8450. 1987
Site-directed chemical modification of horse cytochrome c results in changes in antigenicity due to local and long-range conformational perturbations. 262:11591-11597. 1987
Structural studies and isolation of cdna clones providing the complete sequence of rat-liver dihydropteridine reductase. 262:16412-16416. 1987
Studies of the role of the escherichia-coli heat-shock regulatory protein sigma-32 by the use of monoclonal-antibodies. 262:5404-5407. 1987
The atpase core of a clathrin uncoating protein. 262:746-751. 1987
Two nuclear factors compete for the skeletal muscle actin promoter. 262:9429-9432. 1987
Reduction of 2,4,6-trinitrobenzenesulfonate by glutathione reductase and the effect of NADP+ on the electron transfer. 261:1629-1635. 1986
Simple inhibition studies for distinction between homodimeric and heterodimeric isoenzymes of glutathione transferase. 261:1048-1051. 1986
A bacterial and silkworm aminoacyl-tRNA synthetase have a common epitope which maps to the catalytic domain of each. 261:5241-5244. 1986
A novel prefusion complex formed during protein-transport between golgi cisternae in a cell-free system. 261:2202-2207. 1986
A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase. 261:15474-15479. 1986
Active site-directed inhibition of rabbit cytochrome P-450 1 by amino-substituted steroids. 261:10204-10209. 1986
Ammonium-chloride interferes with a distinct step in the biosynthesis and cell-surface expression of human melanoma-type chondroitin sulfate proteoglycan. 261:3600-3606. 1986
Apolipoprotein-b mediates the capacity of low-density-lipoprotein to suppress neutrophil stimulation by particulates. 261:5662-5667. 1986
Assignment of methylene proton resonances in NMR-spectra of embryonic and transformed-cells to plasma-membrane triglyceride. 261:3048-3053. 1986
Atp-coupled transport of vesicular stomatitis virus-g protein - functional boundaries of secretory compartments. 261:4690-4696. 1986
Atp-coupled transport of vesicular stomatitis virus-g protein between the endoplasmic-reticulum and the golgi. 261:4681-4689. 1986
Characterization of a unique glycoprotein antigen expressed on the surface of human neuroblastoma-cells. 261:299-305. 1986
Crystallographic characterization of a photoactive yellow protein with photochemistry similar to sensory rhodopsin. 261:3850-3851. 1986
Crystallographic characterization of recombinant human CuZn superoxide-dismutase. 261:6215-6218. 1986
Differential subcompartmentation of terminal glycosylation in the golgi-apparatus of intestinal absorptive and goblet cells. 261:14307-14312. 1986
Evidence for a redox-linked ionizable group associated with the 2fe-2s cluster of thermus rieske protein. 261:2768-2771. 1986
Influenza-c virus uses 9-o-acetyl-n-acetylneuraminic acid as a high-affinity receptor determinant for attachment to cells. 261:5947-5951. 1986
Inhibition of post-translational modification and surface expression of a melanoma-associated chondroitin sulfate proteoglycan by diethylcarbamazine or ammonium chloride. 261:5121-5129. 1986
Interaction of S-protein of complement with thrombin and antithrombin-III during coagulation - protection of thrombin by S-protein from antithrombin-III inactivation. 261:7387-7392. 1986
Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions. 261:6643-6646. 1986
Isolation and characterization of a collagen binding domain in human von Willebrand factor. 261:15310-15315. 1986
Lipoxin-a - stereochemistry and biosynthesis. 261:6340-6345. 1986
Parallel expression of the mb19 genetic-polymorphism in apoprotein b-100 and apoprotein b-48 - evidence that both apoproteins are products of the same gene. 261:2995-2998. 1986
Physicochemical properties of the N-formyl peptide receptor on human neutrophils. 261:1854-1857. 1986
Rat Sertoli cells secrete a growth factor that blocks epidermal growth factor (EGF) binding to its receptor. 261:4076-4080. 1986
Receptor interconversion model of hormone action. I. ATP-mediated conversion of estrogen receptors from a high to lower affinity state and its relationship to antiestrogen action. 261:7011-7017. 1986
Receptor interconversion model of hormone action. II. Nucleotide-mediated conversion of estrogen receptors from nonsteroid binding to the lower affinity binding state. 261:7018-7025. 1986
Steady-state and transient-state kinetic-studies on the oxidation of 3,4-dimethoxybenzyl alcohol catalyzed by the ligninase of phanerocheate-chrysosporium burds. 261:1687-1693. 1986
Steady-state kinetic-studies of superoxide dismutases - saturative behavior of the copper-containing and zinc-containing protein. 261:3000-3005. 1986
The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragments. 261:2579-2585. 1986
von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib. 261:381-385. 1986
A DNA primase from yeast - purification and partial characterization. 260:4995-5002. 1985
A detergent-activated tyrosinase from xenopus-laevis .1. Purification and partial characterization. 260:2535-2541. 1985
A detergent-activated tyrosinase from xenopus-laevis .2. Detergent activation and binding. 260:2542-2546. 1985
A homolog of alpha-2-macroglobulin purified from the hemolymph of the horseshoe-crab limulus-polyphemus. 260:2715-2719. 1985
Atp catalyzes the sequestration of clathrin during enzymatic uncoating. 260:57-62. 1985
Binding and activation of plasminogen on the platelet surface. 260:4303-4311. 1985
Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. 260:11581-11587. 1985
Enzymatic dissociation of clathrin cages in a 2-stage process. 260:44-49. 1985
Evidence for n coordination to fe in the 2fe-2s clusters of thermus rieske protein and phthalate dioxygenase from pseudomonas. 260:3251-3254. 1985
Host-mediated selection of influenza-virus receptor variants - sialic acid alpha-2,6gal-specific clones of a/duck/ukraine/1/63 revert to sialic acid-alpha-2,3gal-specific wild-type inovo. 260:7362-7367. 1985
Immunochemical heterogeneity of human-plasma high-density lipoproteins - identification with apolipoprotein a-i-specific and a-ii-specific monoclonal-antibodies. 260:2982-2993. 1985
Iron-sulfur cluster in aconitase - crystallographic evidence for a 3-iron center. 260:2328-2333. 1985
Mechanism of androgen-receptor augmentation. Analysis of receptor synthesis and degradation by the density-shift technique. 260:455-461. 1985
Mechanism of the glucocorticoid regulation of growth of the androgen-sensitive prostate-derived R3327H-G8-A1 tumor cell line. 260:2454-2463. 1985
Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1. 260:3347-3354. 1985
Phosphorylation of the nuclear lamins during interphase and mitosis. 260:624-632. 1985
Primary structure of histidine-tRNA synthetase and characterization of hisS transcripts. 260:10063-10068. 1985
Protein-protein interactions in contact activation of blood-coagulation - binding of high molecular-weight kininogen and the 5-(iodoacetamido)fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light-chains. 260:2434-2443. 1985
Purification and characterization of an o-acetylsialic acid-specific lectin from a marine crab cancer-antennarius. 260:8850-8856. 1985
Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. 260:14304-14310. 1985
Regulation of the oxidative response of human granulocytes to chemoattractants. No evidence for stimulated traffic of redox enzymes between endo and plasma membranes. 260:6541-6547. 1985
Sialylation of glycoprotein oligosaccharides with n-acetylneuraminic, n-glycolylneuraminic, and n-o-diacetylneuraminic acids. 260:8838-8849. 1985
Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor. 260:1461-1467. 1985
Stoichiometric binding of apolipoprotein b-specific monoclonal-antibodies to low-density lipoproteins. 260:956-960. 1985
The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450. 260:5427-5434. 1985
Two classes of binding sites for uncoating protein in clathrin triskelions. 260:10050-10056. 1985
Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity. 260:2226-2230. 1985
2-Propylthiouracil does not replace glutathione for the glutathione transferases. 259:7409-7410. 1984
Metal dissociation constants for glyoxalase I reconstituted with Zn2+, Co2+, Mn2+, and Mg2+. 259:11426-11429. 1984
NMR and computer modeling studies of the conformations of glutathione derivatives at the active site of glyoxalase I. 259:11436-11447. 1984
A monoclonal-antibody recognizes an o-acylated sialic-acid in a human melanoma-associated ganglioside. 259:7453-7459. 1984
Anti-apoprotein-b monoclonal-antibodies detect human low-density lipoprotein polymorphism. 259:6423-6430. 1984
Biosynthetic-studies of proteoglycans in human-melanoma cells with a monoclonal-antibody to a core glycoprotein of chondroitin sulfate proteoglycans. 259:2733-2741. 1984
Demonstration of peptide-n-glycosidase-f activity in endo-beta-n-acetylglucosaminidase f preparations. 259:700-704. 1984
Erythrocyte membrane tropomyosin. Purification and properties. 259:5978-5989. 1984
Evidence for participation of a multiprotein complex in yeast DNA replication in vitro. 259:6852-6857. 1984
Purification and characterization of the rieske iron-sulfur protein from thermus-thermophilus - evidence for a 2fe-2s cluster having non-cysteine ligands. 259:124-133. 1984
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. 259:14914-14921. 1984
Rabbit muscle creatine phosphokinase. CDNA cloning, primary structure and detection of human homologues. 259:14317-14320. 1984
Respiratory proteins from the extremely thermophilic aerobic bacterium, thermus-thermophilus - purification procedures for cytochrome-c552, cytochrome-c555,549, and cytochrome-c1aa3 and chemical evidence for a single subunit cytochrome-aa3. 259:112-123. 1984
Studies on cytochrome-c oxidase activity of the cytochrome-c1aa3 complex from thermus-thermophilus. 259:1031-1036. 1984
The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil. 259:5661-5669. 1984
Three monoclonal antibodies to rabbit microsomal cytochrome P-450 1 recognize distinct epitopes that are shared to different degrees among other electrophoretic types of cytochrome P-450. 259:5887-5892. 1984
Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2. 259:3714-3719. 1984
Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product. 259:8059-8062. 1984
13C NMR studies of the product complex of glyoxalase I. 258:6823-6826. 1983
Octahedral metal coordination in the active site of glyoxalase I as evidenced by the properties of Co(II)-glyoxalase I. 258:2091-2093. 1983
Reversal of the reaction catalyzed by glyoxalase I. Calculation of the equilibrium constant for the enzymatic reaction. 258:8872-8875. 1983
Allosteric regulation of the 16-alpha-hydroxylation of progesterone as catalyzed by rabbit microsomal cytochrome-p-450-3b. 258:2785-2788. 1983
An endopeptidase inhibitor, similar to mammalian alpha-2-macroglobulin, detected in the hemolymph of an invertebrate, limulus-polyphemus. 258:7903-7906. 1983
Characterization of 3-iron ferredoxins by means of the linear electric-field effect in electron-paramagnetic-res. 258:3014-3016. 1983
Comparison of the 34,000-da pp60src substrate and a 38,000-da phosphoprotein identified by monoclonal-antibodies. 258:8497-8502. 1983
Cyclic GMP efflux from liver slices. 258:6882-6886. 1983
Detection of a nucleolar 7-2 ribonucleoprotein and a cytoplasmic 8-2 ribonucleoprotein with autoantibodies from patients with scleroderma. 258:1383-1386. 1983
Identification of a La protein binding site in a RNA polymerase III transcript (4.5 I RNA). 258:8352-8356. 1983
In vitro association of a replication complex with a yeast chromosomal replicator. 258:2754-2757. 1983
Isolation and functional-characterization of the active light chain of activated human-blood coagulation factor-XI. 258:9669-9675. 1983
Leghemoglobin .6. Kinetic, nuclear magnetic-resonance, and optical studies of ph-dependence of oxygen and carbon-monoxide binding. 258:2254-2259. 1983
Mossbauer study of beef-heart cytochrome-oxidase - comparative-study of the bovine enzyme and cytochrome-c1aa3 from thermus-thermophilus. 258:8543-8546. 1983
Photoaffinity labeling of the N-formyl peptide receptor binding site of intact human polymorphonuclear leukocytes. A label suitable for following the fate of the receptor-ligand complex. 258:649-654. 1983
Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase. 258:637-641. 1983
Single-crystals of cadmium, zinc metallothionein. 258:6255-6257. 1983
Structure of azotobacter-vinelandii 7fe ferredoxin - amino-acid-sequence and electron-density maps of residues. 258:508-522. 1983
Studies of the ferredoxin from thermus-thermophilus. 258:3008-3013. 1983
Sulfatide-dependent autoactivation of human-blood coagulation Factor-XII (Hageman-factor). 258:8215-8222. 1983
The fate of an N-formylated chemotactic peptide in stimulated human granulocytes. Subcellular fractionation studies. 258:1968-1977. 1983
The interaction of arsenite with xanthine-oxidase. 258:4849-4856. 1983
The primary structure of the alcohol dehydrogenase gene from the fission yeast Schizosaccharomyces pombe. 258:143-149. 1983
The t3-complex on human lymphocytes-t involves 4 structurally distinct glycoproteins. 258:5135-5141. 1983
Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol. 257:9909-9912. 1982
Nuclear relaxation studies of the role of the essential metal in glyoxalase I. 257:10023-10029. 1982
The in vitro transcription-translation of DNA and RNA templates by extracts of Rhodopseudomonas sphaeroides. Optimization and comparison of template specificity with Escherichia coli extracts and in vivo synthesis. 257:5110-5121. 1982
A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils. The dependence of secretion upon receptor occupancy. 257:5471-5475. 1982
A high-yield purification procedure for alpha-chain and beta-chain of hla-dr antigens. 257:7940-7943. 1982
A study of the electron-paramagnetic resonance properties of single monoclinic crystals of bovine superoxide-dismutase. 257:336-344. 1982
Chemical characterization of a neural cell-adhesion molecule purified from embryonic brain membranes. 257:7720-7729. 1982
Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains. 257:1064-1069. 1982
Functional and structural polymorphism of rabbit microsomal cytochrome P-450 form 3b. 257:9315-9323. 1982
Gene for Escherichia coli glycyl-tRNA synthetase has tandem subunit coding regions in the same reading frame. 257:12503-12508. 1982
Identification of a gal-beta-1 - 3glcnac alpha-2 - 3 sialyltransferase in rat-liver. 257:4034-4037. 1982
Immunochemical heterogeneity of human-plasma apolipoprotein-b .1. Apolipoprotein-b binding of mouse hybridoma antibodies. 257:5213-5221. 1982
Immunochemical heterogeneity of human-plasma apolipoprotein-b .2. Expression of apolipoprotein-b epitopes on native lipoproteins. 257:5222-5228. 1982
Isolation and functional-properties of the heavy and light-chains of human-plasma kallikrein. 257:4300-4305. 1982
Mossbauer study of a bacterial cytochrome-oxidase - cytochrome c1aa3 from thermus-thermophilus. 257:2489-2492. 1982
Newcastle-disease virus contains a linkage-specific glycoprotein sialidase - application to the localization of sialic-acid residues in n-linked oligosaccharides of alpha-1 acid glycoprotein. 257:2734-2738. 1982
Purification of a gal-beta-1- 4glcnac alpha-2- 6 sialyltransferase and a gal-beta-1- 3(4)glcnac alpha-2- 3 sialyltransferase to homogeneity from rat-liver. 257:3835-3844. 1982
Sialylation of glycoprotein oligosaccharides n-linked to asparagine - enzymatic characterization of a gal-beta-1- 3(4)glcnac alpha-2- 3 sialyltransferase and a gal-beta-1- 4glcnac alpha-2- 6 sialyltransferase from rat-liver. 257:3845-3853. 1982
Single-crystals of the iron-sulfur enzyme aconitase. 257:9061-9063. 1982
Spin state and unfolding equilibria of ferricytochrome c in acidic solutions. 257:2267-2273. 1982
Amino acid sequence of an analogous peptide from two forms of cytochrome P-450. 256:1405-1408. 1981
An inhibitor of plasminogen activator in rabbit endothelial cells. 256:4142-4145. 1981
Characterization of crystals of tetrameric manganese superoxide-dismutase from thermus-thermophilus hb8. 256:5857-5859. 1981
Cloning, partial sequencing, and in vitro transcription of the gene for alanine tRNA synthetase. 256:205-211. 1981
Different cell-surface receptor determinants of antigenically similar influenza-virus hemagglutinins. 256:8357-8363. 1981
Equilibrium properties of xanthine-oxidase containing fad analogs of varying oxidation-reduction potential. 256:8933-8940. 1981
Immunochemical mapping of the conformation of human-fibrinogen - the gamma-95-264 segment is inaccessible to antibody in native fibrinogen but progressively exposed by plasmic cleavage. 256:8018-8023. 1981
In vitro transcription of the histidine operon. Identification of the his promoter and leader and readthrough transcripts. 256:10747-10750. 1981
Purification and properties of alanine tRNA synthetase from Escherichia coli. A tetramer of identical subunits. 256:198-204. 1981
Specificity in the activation and inhibition by flavonoids of benzo alpha pyrene hydroxylation by cytochrome-p-450 isozymes from rabbit liver-microsomes. 256:897-901. 1981
Stimulation of pituitary gonadotropin release does not require internalization of gonadotropin-releasing hormone. 256:1098-1100. 1981
Structure of a 7fe ferredoxin from azotobacter-vinelandii. 256:4185-4192. 1981
Superoxide-dismutase - examination of the metal-binding sites by electron-spin echo spectroscopy. 256:1910-1914. 1981
The kinetics of neutrophil activation. The response to chemotactic peptides depends upon whether ligand-receptor interaction is rate-limiting. 256:9909-9914. 1981
The structure of the lentil (lens-culinaris) lectin - amino-acid-sequence determination and prediction of the secondary structure. 256:5550-5560. 1981
Binding of 2-hydroxyestradiol to rat anterior pituitary cell membranes. 255:9838-9843. 1980
Immunochemical studies of human high molecular-weight kininogen and of its complexes with plasma prekallikrein or kallikrein. 255:3952-3958. 1980
Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in adp-induced platelet-aggregation. 255:154-161. 1980
Iron-sulfur clusters in azotobacter ferredoxin at 2.5 a resolution. 255:1797-1800. 1980
Isolation and characterization of a constitutive form of rabbit liver microsomal cytochrome P-450. 255:304-309. 1980
Kinetic studies on muscarinic antagonist-agonist competition. 255:2649-2651. 1980
The binding of substrates and a product of the enzymatic reaction to glutathione S-transferase A. 254:7085-7089. 1979
Affinity labeling of creatine kinase by N-(2,3-epoxypropyl)-N-amidinoglycine. 254:1879-1886. 1979
Aminoacyl-tRNA synthetase-catalyzed cleavage of the glycosidic bond of 5-halogenated uridines. 254:12277-12280. 1979
Biosynthesis of mammalian glycoproteins - glycosylation pathways in the synthesis of the nonreducing terminal sequences. 254:2531-2541. 1979
Carbohydrate composition and identification of blood group A, B, and H oligosaccharide structures on human Factor VIII/von Willebrand factor. 254:754-760. 1979
Enzymatic characterization of beta-d-galactoside alpha-2- 3 sialytransferase from porcine sub-maxillary gland. 254:4444-4451. 1979
Evidence for essential disulfide bonds in beta-1-adrenergic receptors of turkey erythrocyte-membranes - inactivation by dithiothreitol. 254:4462-4469. 1979
Human high molecular-weight kininogen - studies of structure-function-relationships and of proteolysis of the molecule occurring during contact activation of plasma. 254:2020-2027. 1979
Human-platelets possess an inducible and saturable receptor specific for fibrinogen. 254:5357-5363. 1979
Identification of a nuclear protein (Scl-70) as a unique target of human antinuclear antibodies in scleroderma. 254:10514-10522. 1979
Isolation and characterization of nuclear ribonucleoprotein complexes using human anti-nuclear ribonucleoprotein antibodies. 254:3608-3616. 1979
Isomerization of the muscarinic receptor . antagonist complex. 254:5595-5598. 1979
Localization and characterization of the cleavage-associated neoantigen locus in the e-domain of fibrinogen. 254:672-678. 1979
Metal-free southern bean mosaic-virus crystals. 254:5243-5245. 1979
Purification to homogeneity of a beta-galactoside alpha-2- 3 sialytransferase and partial-purification of an alpha-n-acetylgalactosaminide alpha-2- 6 sialytransferase from porcine sub-maxillary glands. 254:4434-4442. 1979
Restoration of specific myxovirus receptors to asialoerythrocytes by incorporation of sialic-acid with pure sialytransferases. 254:2120-2124. 1979
Role of sialic-acid in the expression of human mn blood-group antigens. 254:2112-2119. 1979
Two crystal forms of Azotobacter ferredoxin. 254:3598-3599. 1979
Binding and functional properties of concanavalin-a and its derivatives .1. Mono-valent, divalent, and tetravalent derivatives stable at physiological ph. 253:3000-3007. 1978
Binding and functional properties of concanavalin-a and its derivatives .2. Proteolytic product with saccharide-binding activity. 253:3008-3015. 1978
Binding and functional properties of concanavalin-a and its derivatives .3. Interactions with indoleacetic-acid and other hydrophobic ligands. 253:3016-3022. 1978
Carbohydrate on human factor viii von willebrand factor - impairment of function by removal of specific galactose residues. 253:7202-7206. 1978
Human-blood coagulation factor-IX - purification, properties, and mechanism of activation by activated factor-XI. 253:5946-5951. 1978
Identification of major cytochrome-P-450 form transplacentally induced in neonatal rabbits by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 253:8640-8647. 1978
Major developmentally regulated protein complex in membranes of dictyostelium. 253:5133-5139. 1978
Sialyltransferases and fucosyltransferases in biosynthesis of asparaginyl-linked oligosaccharides in glycoproteins - mutually exclusive glycosylation by beta-galactoside -alpha-2- 6-sialyltransferase and n-acetylglucosaminide -alpha-1- 3-fucosyltransferase. 253:5617-5624. 1978
Adhesion among neural cells of chick-embryo .1. Immunological assay for molecules involved in cell-cell binding. 252:6835-6840. 1977
Adhesion among neural cells of chick-embryo .2. Purification and characterization of a cell-adhesion molecule from neural retina. 252:6841-6845. 1977
Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy. 252:2881-2890. 1977
Enzymatic properties of beta-d-galactoside alpha-2- 6 sialyltransferase from bovine colostrum. 252:2363-2371. 1977
Human blood coagulation factor-XI - purification, properties, and mechanism of activation by activated factor-XII. 252:6432-6437. 1977
Immunochemical homology between a-alpha and a d.E complex-dependent site of gamma chains of fibrinogen. 252:8917-8923. 1977
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on cdp-agarose. 252:2356-2362. 1977
Radioiodination of proteins in single polyacrylamide-gel slices - tryptic peptide analysis of all major members of complex multicomponent systems using microgram quantities of total protein. 252:6510-6515. 1977
Reactivation of asialo-rabbit liver binding-protein by resialylation with beta-d-galactoside alpha2- 6 sialyltransferase. 252:8624-8628. 1977
Resolution of 2 forms of cytochrome-P-450 from liver-microsomes of rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. 252:2839-2845. 1977
Revised amino-acid sequence of qbeta coat protein between positions 1 and 60. 252:990-993. 1977
Systematic purification of 5 glycosidases from streptococcus-(diplococcus)-pneumoniae. 252:8615-8623. 1977
Direct evidence for manganese(iii) binding to manganosuperoxide dismutase of escherichia-coli-b. 251:6157-6159. 1976
Formation of hybrid concanavalin-a molecules by subunit exchange. 251:4622-4628. 1976
Isotope labeling of free and aminoacyl transfer RNA synthetase-bound transfer RNA. 251:6823-6830. 1976
Muscarinic acetylcholine receptor from rat brain. Partial purification and characterization. 251:1543-1547. 1976
Physical and chemical studies on bacterial superoxide dismutases - purification and some anion binding properties of iron-containing protein of escherichia-coli-b. 251:5472-5477. 1976
Synthesis in vitro of intrinsic membrane proteins by free, membrane-bound, and golgi apparatus-associated polyribosomes from rat-liver. 251:5054-5068. 1976
The ovalbumin gene. Partial purification of the coding strand. 251:3868-3874. 1976
Purification and characterization of the flavoenzyme glutathione reductase from rat liver. 250:5475-5480. 1975
Cleavage-associated neoantigenic marker for a gamma chain site in nh2-terminal aspect of fibrinogen molecule. 250:3386-3392. 1975
Complement activation by a univalent hapten-antibody complex. 250:4918-4925. 1975
Conformational and structural modulation of nh2-terminal regions of fibrinogen and fibrin associated with plasmin cleavage. 250:3393-3398. 1975
Covalent and 3-dimensional structure of concanavalin-a .1. Amino-acid sequence of cyanogen-bromide fragments f1 and f2. 250:1490-1502. 1975
Covalent and 3-dimensional structure of concanavalin-a .2. Amino-acid sequence of cyanogen-bromide fragment f3. 250:1503-1512. 1975
Covalent and 3-dimensional structure of concanavalin-a .3. Structure of monomer and its interactions with metals and saccharides. 250:1513-1524. 1975
Covalent and 3-dimensional structure of concanavalin-a .4. Atomic coordinates, hydrogen-bonding, and quaternary structure. 250:1525-1547. 1975
Interactions of bovine neurophysins with neurohypophyseal hormones - role of tyrosine-49. 250:5215-5220. 1975
Isolation of lectins of different specificities on a single affinity adsorbent. 250:7535-7538. 1975
Progesterone binding components of chick oviduct. X. Purification by affinity chromatography. 250:4220-4228. 1975
Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases. 250:4440-4444. 1975
Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases. 250:4433-4439. 1975
Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. 249:5924-5932. 1974
Fibrinolysis associated with oncogenic transformation. Morphological correlates. 249:4312-4320. 1974
Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies. 249:6895-6900. 1974
Plasminogen, the serum proenzyme activated by factors from cells transformed by oncogenic viruses. 249:4306-4311. 1974
Random pathway mechanism involving parallel one- and two- substrate branches for glyoxalase i from yeast. 249:901-903. 1974
Rotational correlation time of concanavalin-a after interaction with a fluorescent-probe. 249:7018-7023. 1974
Carbamyl phosphate binding to aspartate transcarbamylase. Partial saturation and its alteration by succinate. 248:5063-5066. 1973
Complex-formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region - absorbance and circular-dichroism difference spectroscopic studies. 248:7975-7978. 1973
Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions. 248:5057-5062. 1973
Nuclear magnetic resonance titration curves of histidine ring protons. IV. The effects of phosphate and sulfate on ribonuclease. 248:4305-4310. 1973
Preliminary report on the electron paramagnetic resonance spectra of single crystals of bovine erythrocyte superoxide dismutase. 248:7617-7619. 1973
Studies on reconstitution of bovine erythrocyte superoxide dismutase .4. Preparation and some properties of enzyme in which co(ii) is substituted for zn(ii). 248:4229-4234. 1973
The stereochemistry of pyridoxal phosphate enzymes. The absolute stereochemistry of cofactor c' 4 protonation in the transamination of holoserine hydroxymethylase by d-alanine. 248:841-842. 1973
Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy. 247:6482-6490. 1972
Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine. 247:2961-2964. 1972
Conformational changes in concanavalin a. 246:4369-4370. 1971
Fluorescent probes for conformational states of proteins. Iv. The pepsinogen-pepsin conversion. 246:1185-1191. 1971
Location of the saccharide binding site of concanavalin a. 246:6123-6125. 1971
High resolution proton magnetic resonance studies of cyanoferrimyoglobins and alkylated derivatives from different species. 245:1947-1953. 1970
Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. 245:2667-2671. 1970
The purification and properties of bovine thrombin. 245:4857-4862. 1970
Interaction of human hemoglobin with adenine nucleotides. 244:5084-5086. 1969
Interaction of lysozyme with alpha-N-acetyl-D-glucosamine. 244:3643-3646. 1969
Properties of deoxyribonuclease 3 from mammalian tissues. 244:5014-5019. 1969
Dynamics of lysozyme-saccharide interactions. 243:3771-3774. 1968
Isolation and chemical properties of porcine thyrocalcitonin. 243:5739-5747. 1968
Isolation of an acidic protein from rat brain. 243:6234-6241. 1968
Squalene-2,3-oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. 242:4182-4191. 1967
Characterization of sheep prolactin. 239:1777-1782. 1964

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