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Activity-dependent mapping in the retinotectal projection

Academic Article
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Overview

authors

  • Debski, E. A.
  • Cline, Hollis

publication date

  • February 2002

journal

  • Current Opinion in Neurobiology  Journal

abstract

  • It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitric oxide and brain-derived neurotrophic factor, candidate retrograde messengers, and serotonin and acetylcholine, modulators of neuronal excitability, all affect mapping. These studies indicate that the mapping process intersects with other processes fundamental to visual system development and function, such as process outgrowth, synaptic turnover and neuromodulation.

subject areas

  • Animals
  • Brain Mapping
  • Neural Pathways
  • Retina
  • Superior Colliculi
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Identity

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/s0959-4388(02)00295-7

PubMed ID

  • 11861170
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Additional Document Info

start page

  • 93

end page

  • 99

volume

  • 12

issue

  • 1

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