Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Evidence that angiotensin-converting enzyme inhibitor use diminishes the need for coronary revascularization after stenting

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Ellis, S. G.
  • Lincoff, A. M.
  • Whitlow, P. L.
  • Raymond, R. E.
  • Franco, I.
  • Schneider, J. P.
  • Topol, Eric

publication date

  • April 2002

journal

  • American Journal of Cardiology  Journal

abstract

  • Restenosis after stenting, in contrast to balloon angioplasty, is predominantly due to neointima formation. Angiotensin-converting enzyme (ACE) inhibitors diminish neointima formation in animal models of arterial injury. In an observational study, 1,598 patients who were treated from 1994 to 1997 with coronary stents and prospectively followed for clinical events were divided into 2 groups: those receiving ACE inhibitors at the time of stenting (n = 345) and those who did not (n = 1,253). Multivariate logistic regression was used to adjust for imbalances between populations with regard to elements relevant to risk of 12-month coronary revascularization, which was the primary study end point. After adjustment, ACE inhibitor usage remained significantly protective against revascularization (odds ratio [OR] 0.46, 95% confidence interval 0.29 to 0.73, p = 0.001). Protection was not observed in patients treated with balloon angioplasty alone during the same period (OR 1.06, p = 0.33), which is consistent with the results of prior randomized trials. ACE inhibitors appear to decrease late revascularization, possibly due to a reduction in restenosis after coronary stenting.

subject areas

  • Aged
  • Angioplasty, Balloon, Coronary
  • Angiotensin-Converting Enzyme Inhibitors
  • Case-Control Studies
  • Coronary Restenosis
  • Coronary Stenosis
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Myocardial Revascularization
  • Prospective Studies
  • Sensitivity and Specificity
  • Stents
  • Time Factors
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/s0002-9149(02)02242-7

PubMed ID

  • 11950431
scroll to property group menus

Additional Document Info

start page

  • 937

end page

  • 940

volume

  • 89

issue

  • 8

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support