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The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity

Academic Article
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  • Research
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Overview

authors

  • Bajjuri, K. M.
  • Liu, Y. A.
  • Liu, C.
  • Sinha, Subhash

publication date

  • January 2011

journal

  • ChemMedChem  Journal

subject areas

  • Aminobenzoates
  • Animals
  • Breast Neoplasms
  • Cell Line, Tumor
  • Cysteine Endopeptidases
  • Disease Models, Animal
  • Enzyme Activation
  • Female
  • Humans
  • Mice
  • Neoplasm Metastasis
  • Oligopeptides
  • Prodrugs
  • Tumor Burden
  • Weight Loss
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Research

keywords

  • auristatins
  • cytotoxins
  • legumain
  • prodrugs
  • proteases
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Identity

PubMed Central ID

  • PMC3549592

International Standard Serial Number (ISSN)

  • 1860-7179

Digital Object Identifier (DOI)

  • 10.1002/cmdc.201000478

PubMed ID

  • 21154805
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Additional Document Info

start page

  • 54

end page

  • 59

volume

  • 6

issue

  • 1

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