Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Statistical genetics concepts and approaches in schizophrenia and related neuropsychiatric research

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Schork, Nicholas
  • Greenwood, T. A.
  • Braff, D. L.

publication date

  • January 2007

journal

  • Schizophrenia Bulletin  Journal

abstract

  • Statistical genetics is a research field that focuses on mathematical models and statistical inference methodologies that relate genetic variations (ie, naturally occurring human DNA sequence variations or "polymorphisms") to particular traits or diseases (phenotypes) usually from data collected on large samples of families or individuals. The ultimate goal of such analysis is the identification of genes and genetic variations that influence disease susceptibility. Although of extreme interest and importance, the fact that many genes and environmental factors contribute to neuropsychiatric diseases of public health importance (eg, schizophrenia, bipolar disorder, and depression) complicates relevant studies and suggests that very sophisticated mathematical and statistical modeling may be required. In addition, large-scale contemporary human DNA sequencing and related projects, such as the Human Genome Project and the International HapMap Project, as well as the development of high-throughput DNA sequencing and genotyping technologies have provided statistical geneticists with a great deal of very relevant and appropriate information and resources. Unfortunately, the use of these resources and their interpretation are not straightforward when applied to complex, multifactorial diseases such as schizophrenia. In this brief and largely nonmathematical review of the field of statistical genetics, we describe many of the main concepts, definitions, and issues that motivate contemporary research. We also provide a discussion of the most pressing contemporary problems that demand further research if progress is to be made in the identification of genes and genetic variations that predispose to complex neuropsychiatric diseases.

subject areas

  • Chromosome Mapping
  • Cross-Sectional Studies
  • Genetic Predisposition to Disease
  • Genetic Research
  • Genetic Variation
  • Genotype
  • Human Genome Project
  • Humans
  • Models, Genetic
  • Models, Statistical
  • Phenotype
  • Quantitative Trait Loci
  • Risk Assessment
  • Schizophrenia
  • Social Environment
scroll to property group menus

Research

keywords

  • association studies
  • genetic epidemiology
  • genotyping
  • hapmap
scroll to property group menus

Identity

PubMed Central ID

  • PMC2632283

International Standard Serial Number (ISSN)

  • 0586-7614

Digital Object Identifier (DOI)

  • 10.1093/schbul/sbl045

PubMed ID

  • 17035359
scroll to property group menus

Additional Document Info

start page

  • 95

end page

  • 104

volume

  • 33

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support