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Behavioral and neurochemical studies on brain aging in galanin overexpressing mice

Academic Article
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Overview

authors

  • Pirondi, S.
  • Kuteeva, E.
  • Giardino, L.
  • Ferraro, L.
  • Antonelli, T.
  • Bartfai, Tamas
  • Ogren, S. O.
  • Hokfelt, T.
  • Calza, L.

publication date

  • June 2005

journal

  • Neuropeptides  Journal

abstract

  • To study possible involvement of galanin in brain aging quality, we have investigated behavioral, neurochemical and morphological parameters in aged mice overexpressing galanin under the platelet-derived growth factor B promoter (GalOE mice) compared to wild-type littermates (WT mice). The behavioral analysis in the forced swim test showed that old GalOE animals spent more time in immobility compared to WT. In the activity cage test, galanin overexpression counteracted the age-induced decrease in exploratory behavior. The neurochemical analysis showed a 30% decrease in noradrenaline overflow in the cerebral cortex of WT old mice that was not present in age-matched GalOE mice. Our results indicate that overexpression of galanin can influence several behavioral and neurochemical parameters in old mice.

subject areas

  • Aging
  • Animals
  • Anxiety
  • Behavior, Animal
  • Brain
  • Depression
  • Dopamine
  • Exploratory Behavior
  • Galanin
  • Gene Expression
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Norepinephrine
  • Tritium
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Research

keywords

  • anxiety
  • cortex
  • exploratory behavior
  • hippocampus
  • neuropeptide
  • porsolt test
  • stress
  • transgenic mice
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Identity

International Standard Serial Number (ISSN)

  • 0143-4179

Digital Object Identifier (DOI)

  • 10.1016/j.npep.2005.02.006

PubMed ID

  • 15944027
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Additional Document Info

start page

  • 305

end page

  • 312

volume

  • 39

issue

  • 3

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