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An autosomal recessive gene that delays expression of lupus in bxsb mice

Academic Article
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Overview

authors

  • Kofler, R.
  • McConahey, P. J.
  • Duchosal, M. A.
  • Balderas, R. S.
  • Theofilopoulos, Argyrios
  • Dixon, F. J.

publication date

  • February 1991

journal

  • Journal of Immunology  Journal

abstract

  • We report the generation and serologic, cellular, histologic, and genetic characteristics of a BXSB/MpJScr substrain, termed BXSB/MpJScr-ll/ll, that has lost early-life male lupus disease. Classic genetic analysis suggested that delayed disease expression results from the action of a single autosomal recessive gene. This putative gene, referred to as ll (long-lived), causes a significant delay in expression of autoimmune serology (total serum IgG and anti-nuclear antibodies levels), monocytosis, and of immune complex-mediated histopathologic changes such as glomerulonephritis, arteritis, and myocardial infarction. Presumably as a consequence of the delayed immunopathology male BXSB/MpJScr-ll/ll mice live three to four times longer than regular BXSB/MpJScr. This strain might be useful for analysis of single genes responsible for severe autoimmune disease expression.

subject areas

  • Animals
  • DNA, Viral
  • Disease Models, Animal
  • Genes, Recessive
  • Genetic Predisposition to Disease
  • Life Expectancy
  • Lupus Erythematosus, Systemic
  • Male
  • Mice
  • Mice, Inbred Strains
  • Retroviridae
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 1991974
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Additional Document Info

start page

  • 1375

end page

  • 1379

volume

  • 146

issue

  • 4

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