recent publications

• academic article

  • Aleshin, A. E., Gramatikova, S., Hura, G. L., Bobkov, A., Strongin, A. Y., Stec, B., Tainer, J. A., Liddington, R. C., Smith, J. W. Crystal and solution structures of a prokaryotic m16b peptidase: An open and shut case Structure  2009 17:1465-1475  DOI:10.1016/j.str.2009.09.009  PMID:19913481  PMCID:PMC3615642
  • Deryugina, E. I., Ratnikov, B. I., Yu, Q., Baciu, P. C., Rozanov, D. V., Strongin, A. Y. Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in furin-negative colon carcinoma LoVo cells Traffic  2004 5:627-641  DOI:10.1111/j.1600-0854.2004.00206.x  PMID:15260832
  • Rozanov, D. V., Deryugina, E. I., Monosov, E. Z., Marchenko, N. D., Strongin, A. Y. Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells Experimental Cell Research  2004 293:81-95  DOI:10.1016/j.yexer.2003.10.006  PMID:14729059
  • Alonso-Escolano, D., Strongin, A. Y., Chung, A. W., Deryugina, E. I., Radomski, M. W. Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins British Journal of Pharmacology  2004 141:241-252  DOI:10.1038/sj.bjp.0705606  PMID:14691052  PMCID:PMC1574193
  • Baciu, P. C., Suleiman, E. A., Deryugina, E. I., Strongin, A. Y. Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells Experimental Cell Research  2003 291:167-175  DOI:10.1016/s0014-4827(03)00387-2  PMID:14597417
  • Deryugina, E. I., Ratnikov, B. I., Strongin, A. Y. Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells International Journal of Cancer  2003 104:533-541  DOI:10.1002/ijc.10977  PMID:12594807
  • Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U. H., Deryugina, E. I., Strongin, A. Y., Bröcker, E. B., Friedl, P. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis Journal of Cell Biology  2003 160:267-277  DOI:10.1083/jcb.200209006  PMID:12527751  PMCID:PMC2172637
  • Ratnikov, B. I., Deryugina, E. I., Strongin, A. Y. Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase Laboratory Investigation  2002 82:1583-1590  DOI:10.1097/01.lab.0000038555.67772.db  PMID:12429818
  • Rozanov, D. V., Ghebrehiwet, B., Ratnikov, B. I., Monosov, E. Z., Deryugina, E. I., Strongin, A. Y. The cytoplasmic tall peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein FEBS Letters  2002 527:51-57  DOI:10.1016/s0014-5793(02)03153-8  PMID:12220632
  • Deryugina, E. I., Ratnikov, B. I., Postnova, T. I., Rozanov, D. V., Strongin, A. Y. Processing of integrin αv subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase Journal of Biological Chemistry  2002 277:9749-9756  DOI:10.1074/jbc.M110269200  PMID:11724803
  • Rozanov, D. V., Ghebrehiwet, B., Postnova, T. I., Eichinger, A., Deryugina, E. I., Strongin, A. Y. The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR Journal of Biological Chemistry  2002 277:9318-9325  DOI:10.1074/jbc.M110711200  PMID:11773076
  • Ratnikov, B. I., Rozanov, D. V., Postnova, T. I., Baciu, P. G., Zhang, H., DiScipio, R. G., Chestukhina, G. G., Smith, J. W., Deryugina, E. I., Strongin, A. Y. An alternative processing of integrin αv subunit in tumor cells by membrane type-1 matrix metalloproteinase Journal of Biological Chemistry  2002 277:7377-7385  DOI:10.1074/jbc.M109580200  PMID:11741954
  • Deryugina, E. I., Soroceanu, L., Strongin, A. Y. Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis Cancer Research  2002 62:580-588  PMID:11809713
  • Rozanov, D. V., Deryugina, E. I., Ratnikov, B. I., Monosov, E. Z., Marchenko, G. N., Quigley, J. P., Strongin, A. Y. Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells Journal of Biological Chemistry  2001 276:25705-25714  DOI:10.1074/jbc.M007921200  PMID:11335709
  • Marchenko, G. N., Ratnikov, B. I., Rozanov, D. V., Godzik, A., Deryugina, E. I., Strongin, A. Y. Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin Biochemical Journal  2001 356:705-718  DOI:10.1042/0264-6021:3560705  PMID:11389678  PMCID:PMC1221897
  • Belkin, A. M., Akimov, S. S., Zaritskaya, L. S., Ratnikov, B. I., Deryugina, E. I., Strongin, A. Y. Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion Journal of Biological Chemistry  2001 276:18415-18422  DOI:10.1074/jbc.M010135200  PMID:11278623
  • Deryugina, E. I., Ratnikov, B., Monosov, E., Postnova, T. I., DiScipio, R., Smith, J. W., Strongin, A. Y. MT1-MMP initiates activation of pro-MMP-2 and integrin αvβ3 promotes maturation of MMP-2 in breast carcinoma cells Experimental Cell Research  2001 263:209-223  DOI:10.1006/excr.2000.5118  PMID:11161720
  • Deryugina, E. I., Bourdon, M. A., Jungwirth, K., Smith, J. W., Strongin, A. Y. Functional activation of integrin αvβ3 in tumor cells expressing membrane-type 1 matrix metalloproteinase International Journal of Cancer  2000 86:15-23  DOI:10.1002/(sici)1097-0215(20000401)86:1<15::aid-ijc3>3.0.co;2-b  PMID:10728589