recent publications

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  • Deng, X., Elkins, J. M., Zhang, J., Yang, Q., Erazo, T., Gomez, N., Choi, H. G., Wang, J., Dzamko, N., Lee, J. D., Sim, T., Kim, N., et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo e pyrimido- 5,4-b diazepine-6(11H)-ones European Journal of Medicinal Chemistry  2013 70:758-767  DOI:10.1016/j.ejmech.2013.10.052  PMID:24239623  PMCID:PMC3914206
  • Yang, Q., Liao, L., Deng, X., Chen, R., Gray, N. S., Yates, J. R., Lee, J. D. BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction Oncogene  2013 32:3156-3164  DOI:10.1038/onc.2012.332  PMID:22869143  PMCID:PMC3493705
  • Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J. M., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., et al. Discovery of potent and selective covalent inhibitors of JNK Chemistry & Biology  2012 19:140-154  DOI:10.1016/j.chembiol.2011.11.010  PMID:22284361  PMCID:PMC3270411
  • Miduturu, C. V., Deng, X. M., Kwiatkowski, N., Yang, W. N. A., Brault, L., Filippakopoulos, P., Chung, E., Yang, Q. K., Schwaller, J., Knapp, S., King, R. W., Lee, J. D., et al. High-throughput kinase profiling: A more efficient approach toward the discovery of new kinase inhibitors Chemistry & Biology  2011 18:868-879  DOI:10.1016/j.chembiol.2011.05.010  PMID:21802008  PMCID:PMC3171802
  • Patricelli, M. P., Nomanbhoy, T. K., Wu, J., Brown, H., Zhou, D., Zhang, J. M., Jagannathan, S., Aban, A., Okerberg, E., Herring, C., Nordin, B., Weissig, H., et al. In situ kinase profiling reveals functionally relevant properties of native kinases Chemistry & Biology  2011 18:699-710  DOI:10.1016/j.chembiol.2011.04.011  PMID:21700206  PMCID:PMC3142620
  • Deng, X. M., Dzamko, N., Prescott, A., Davies, P., Liu, Q. S., Yang, Q. K., Lee, J. D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R., Gray, N. S. Characterization of a selective inhibitor of the parkinson's disease kinase lrrk2 Nature Chemical Biology  2011 7:203-205  DOI:10.1038/nchembio.538  PMID:21378983  PMCID:PMC3287420
  • Deng, X., Yang, Q., Kwiatkowski, N., Sim, T., McDermott, U., Settleman, J. E., Lee, J. D., Gray, N. S. Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a potent and selective inhibitor of Big MAP Kinase 1 ACS Medicinal Chemistry Letters  2011 2:195-200  DOI:10.1021/ml100304b  PMID:21412406  PMCID:PMC3055678
  • Deng, X. M., Nagle, A., Wu, T., Sakata, T., Henson, K., Chen, Z., Kuhen, K., Plouffe, D., Winzeler, E., Adrian, F., Tuntland, T., Chang, J., et al. Discovery of novel 1h-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials Bioorganic & Medicinal Chemistry Letters  2010 20:4027-4031  DOI:10.1016/j.bmcl.2010.05.095  PMID:20610151
  • Yang, Q. K., Deng, X. M., Lu, B. W., Cameron, M., Fearns, C., Patricelli, M. P., Yates, J. R., Gray, N. S., Lee, J. D. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein Cancer Cell  2010 18:258-267  DOI:10.1016/j.ccr.2010.08.008  PMID:20832753  PMCID:PMC2939729
  • Wu, T., Nagle, A., Sakata, T., Henson, K., Borboa, R., Chen, Z., Kuhen, K., Plouffe, D., Winzeler, E., Adrian, F., Tuntland, T., Chang, J., et al. Cell-based optimization of novel benzamides as potential antimalarial leads Bioorganic & Medicinal Chemistry Letters  2009 19:6970-6974  DOI:10.1016/j.bmcl.2009.10.050  PMID:19879133  PMCID:PMC3532596
  • Goldsmith, M., Avni, D., Levy-Rimler, G., Mashiach, R., Ernst, O., Levi, M., Webb, B., Meijler, M. M., Gray, N. S., Rosen, H., Zor, T. A ceramide-1-phosphate analogue, pcera-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages Immunology  2009 127:103-115  DOI:10.1111/j.1365-2567.2008.02928.x  PMID:18793216  PMCID:PMC2678186
  • Avni, D., Goldsmith, M., Ernst, O., Mashiach, R., Tuntland, T., Meijler, M. M., Gray, N. S., Rosen, H., Zor, T. Modulation of tnf alpha, il-10 and il-12p40 levels by a ceramide-1-phosphate analog, pcera-1, in vivo and ex vivo in primary macrophages Immunology Letters  2009 123:1-8  DOI:10.1016/j.imlet.2008.12.011  PMID:19185589
  • Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrian, F., Matzen, J. T., Anderson, P., Nam, T. G., Gray, N. S., et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen Proceedings of the National Academy of Sciences of the United States of America  2008 105:9059-9064  DOI:10.1073/pnas.0802982105  PMID:18579783  PMCID:PMC2440361
  • Hong, J. Y., Lee, J., Min, K. H., Walker, J. R., Peters, E. C., Gray, N. S., Cho, C. Y., Schultz, P. G. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation ACS Chemical Biology  2007 2:171-175  DOI:10.1021/cb600435t  PMID:17348628
  • Galkin, A. V., Mellnick, J. S., Kim, S., Hood, T. L., Li, N. X., Li, L. T., Xia, G., Steensma, R., Chopiuk, G., Jiang, J. Q., Wan, Y. Q., Ding, P., et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK Proceedings of the National Academy of Sciences of the United States of America  2007 104:270-275  DOI:10.1073/pnas.0609412103  PMID:17185414  PMCID:PMC1765448
  • Melnick, J. S., Janes, J., Kim, S., Chang, J. Y., Sipes, D. G., Gunderson, D., Jarnes, L., Matzen, J. T., Garcia, M. E., Hood, T. L., Beigi, R., Xia, G., et al. An efficient rapid system for profiling the cellular activities of molecular libraries Proceedings of the National Academy of Sciences of the United States of America  2006 103:3153-3158  DOI:10.1073/pnas.0511292103  PMID:16492761  PMCID:PMC1413928
  • Luesch, H., Wu, T. Y. H., Ren, P. D., Gray, N. S., Schultz, P. G., Supek, F. A genome-wide overexpression screen in yeast for small-molecule target identification Chemistry & Biology  2005 12:55-63  DOI:10.1016/j.chembiol.2004.10.015  PMID:15664515
  • Wu, X., Ding, S., Ding, G., Gray, N. S., Schultz, P. G. Small molecules that induce cardiomyogenesis in embryonic stem cells Journal of the American Chemical Society  2004 126:1590-1591  DOI:10.1021/ja038950i  PMID:14871063
  • Wignall, S. M., Gray, N. S., Chang, Y. T., Juarez, L., Jacob, R., Burlingame, A., Schultz, P. G., Heald, R. Identification of a novel protein regulating microtubule stability through a chemical approach Chemistry & Biology  2004 11:135-146  DOI:10.1016/j.chembiol.2003.12.019  PMID:15113003
  • Ding, S., Wu, T. Y. H., Brinker, A., Peters, E. C., Hur, W., Gray, N. S., Schultz, P. G. Synthetic small molecules that control stem cell fate Proceedings of the National Academy of Sciences of the United States of America  2003 100:7632-7637  DOI:10.1073/pnas.0732087100  PMID:12794184  PMCID:PMC164638
  • Wu, X., Ding, S., Ding, Q., Gray, N. S., Schultz, P. G. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells Journal of the American Chemical Society  2002 124:14520-14521  DOI:10.1021/ja0283908  PMID:12465946
  • Chang, Y. T., Choi, G., Bae, Y. S., Burdett, M., Moon, H. S., Lee, J. W., Gray, N. S., Schultz, P. G., Meijer, L., Chung, S. K., Choi, K. Y., Suh, P. G., et al. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase ChemBioChem  2002 3:897-901  DOI:10.1002/1439-7633(20020902)3:9<897::aid-cbic897>3.0.co;2-b  PMID:12210991
  • Ding, S., Gray, N. S., Ding, Q., Wu, X., Schultz, P. G. Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines Journal of Combinatorial Chemistry  2002 4:183-186  DOI:10.1021/cc010080i  PMID:11886295
  • Ding, S., Gray, N. S., Wu, X., Ding, Q., Schultz, P. G. A combinatorial scaffold approach toward kinase-directed heterocycle libraries Journal of the American Chemical Society  2002 124:1594-1596  DOI:10.1021/ja0170302  PMID:11853431
  • Chang, Y. T., Wignall, S. M., Rosania, G. R., Gray, N. S., Hanson, S. R., Su, A. I., Merlie, J., Moon, H. S., Sangankar, S. B., Perez, O., Heald, R., Schultz, P. G. Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors Journal of Medicinal Chemistry  2001 44:4497-4500  DOI:10.1021/jm010451+  PMID:11741468
  • Ding, S., Gray, N. S., Ding, Q., Schultz, P. G. Expanding the diversity of purine libraries Tetrahedron Letters  2001 42:8751-8755  DOI:10.1016/s0040-4039(01)01925-6
  • Ding, S., Gray, N. S., Ding, Q., Schultz, P. G. A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines Journal of Organic Chemistry  2001 66:8273-8276  DOI:10.1021/jo016010f  PMID:11722241
  • Wu, T. Y. H., Ding, S., Gray, N. S., Schultz, P. G. Solid-phase synthesis of 2,3,5-trisubstituted indoles Organic Letters  2001 3:3827-3830  DOI:10.1021/ol016525t  PMID:11720546
  • Lin, Q., Jiang, F. Y., Schultz, P. G., Gray, N. S. Design of allele-specific protein methyltransferase inhibitors Journal of the American Chemical Society  2001 123:11608-11613  DOI:10.1021/ja011423j  PMID:11716715
  • Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D., Wood, J. L., Morgan, D. O., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase Nature  2000 407:395-401  PMID:11014197
  • Armstrong, J. I., Portley, A. R., Chang, Y. T., Nierengarten, D. M., Cook, B. N., Bowman, K. G., Bishop, A., Gray, N. S., Shokat, K. M., Schultz, P. G., Bertozzi, C. R. Discovery of carbohydrate sulfotransferase inhibitors from a kinase-directed library Angewandte Chemie-International Edition  2000 39:1303-1306  DOI:10.1002/(sici)1521-3773(20000403)39:7<1303::aid-anie1303>3.0.co;2-0  PMID:10767039
  • Chang, Y. T., Gray, N. S., Rosania, G. R., Sutherlin, D. P., Kwon, S., Norman, T. C., Sarohia, R., Leost, M., Meijer, L., Schultz, P. G. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors Chemistry & Biology  1999 6:361-375  DOI:10.1016/s1074-5521(99)80048-9  PMID:10375538
  • Gray, N. S., Wodicka, L., Thunnissen, Amwh, Norman, T. C., Kwon, S. J., Espinoza, F. H., Morgan, D. O., Barnes, G., LeClerc, S., Meijer, L., Kim, S. H., Lockhart, D. J., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors Science  1998 281:533-538  DOI:10.1126/science.281.5376.533  PMID:9677190
  • Brooks, E. E., Gray, N. S., Joly, A., Kerwar, S. S., Lum, R., Mackman, R. L., Norman, T. C., Rosete, J., Rowe, M., Schow, S. R., Schultz, P. G., Wang, X. B., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation Journal of Biological Chemistry  1997 272:29207-29211  DOI:10.1074/jbc.272.46.29207  PMID:9360999
  • Gray, N. S., Kwon, S., Schultz, P. G. Combinatorial synthesis of 2,9-substituted purines Tetrahedron Letters  1997 38:1161-1164  DOI:10.1016/s0040-4039(97)00014-2
  • Norman, T. C., Gray, N. S., Koh, J. T., Schultz, P. G. A structure-based library approach to kinase inhibitors Journal of the American Chemical Society  1996 118:7430-7431  DOI:10.1021/ja9614934
  • Patten, P. A., Gray, N. S., Yang, P. L., Marks, C. B., Wedemayer, G. J., Boniface, J. J., Stevens, R. C., Schultz, P. G. The immunological evolution of catalysis Science  1996 271:1086-1091  DOI:10.1126/science.271.5252.1086  PMID:8599084