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Roth, B. L.

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    • O'Connor, C., White, K. L., Doncescu, N., Didenko, T., Roth, B. L., Czaplicki, G., Stevens, R. C., Wüthrich , K., Milon, A. NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor Proceedings of the National Academy of Sciences of the United States of America  2015 112:11852-11857  DOI:10.1073/pnas.1510117112  PMID:26372966  PMCID:PMC4586840
    • Fenalti, G., Zatsepin, N. A., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., et al. Structural basis for bifunctional peptide recognition at human delta-opioid receptor Nature Structural & Molecular Biology  2015 22:265-268  DOI:10.1038/nsmb.2965  PMID:25686086  PMCID:PMC4351130
    • Wang, C., Wu, H., Evron, T., Vardy, E., Han, G. W., Huang, X. P., Hufeisen, S. J., Mangano, T. J., Urban, D. J., Katritch, V., Cherezov, V., Caron, M. G., et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nature Communications  2014 5:4355  DOI:10.1038/ncomms5355  PMID:25008467  PMCID:PMC4198951
    • Katritch, V., Fenalti, G., Abola, E. E., Roth, B. L., Cherezov, V., Stevens, R. C. Allosteric sodium in class A GPCR signaling Trends in Biochemical Sciences  2014 39:233-244  DOI:10.1016/j.tibs.2014.03.002  PMID:24767681  PMCID:PMC4106411
    • Fenalti, G., Giguere, P. M., Katritch, V., Huang, X. P., Thompson, A. A., Cherezov, V., Roth, B. L., Stevens, R. C. Molecular control of delta-opioid receptor signalling Nature  2014 506:191-196  DOI:10.1038/nature12944  PMID:24413399  PMCID:PMC3931418
    • Vardy, E., Mosier, P. D., Frankowski, K. J., Wu, H., Katritch, V., Westkaemper, R. B., Aube, J., Stevens, R. C., Roth, B. L. Chemotype-selective modes of action of κ-opioid receptor agonists Journal of Biological Chemistry  2013 288:34470-34483  DOI:10.1074/jbc.M113.515668  PMID:24121503  PMCID:PMC3843062
    • Wang, C., Wu, H., Katritch, V., Han, G. W., Huang, X. P., Liu, W., Siu, F. Y., Roth, B. L., Cherezov, V., Stevens, R. C. Structure of the human smoothened receptor bound to an antitumour agent Nature  2013 497:338-343  DOI:10.1038/nature12167  PMID:23636324  PMCID:PMC3657389
    • Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G. W., Liu, W., Huang, X. P., Vardy, E., McCorvy, J. D., Gao, X., et al. Structural basis for molecular recognition at serotonin receptors Science  2013 340:610-614  DOI:10.1126/science.1232807  PMID:23519210  PMCID:PMC3644373
    • Wacker, D., Wang, C., Katritch, V., Han, G. W., Huang, X. P., Vardy, E., McCorvy, J. D., Jiang, Y., Chu, M., Siu, F. Y., Liu, W., Xu, H. E., et al. Structural features for functional selectivity at serotonin receptors Science  2013 340:615-619  DOI:10.1126/science.1232808  PMID:23519215  PMCID:PMC3644390
    • Wu, H. X., Wacker, D., Mileni, M., Katritch, V., Han, G. W., Vardy, E., Liu, W., Thompson, A. A., Huang, X. P., Carroll, F. I., Mascarella, S. W., Westkaemper, R. B., et al. Structure of the human κ-opioid receptor in complex with JDTic Nature  2012 485:327-332  DOI:10.1038/nature10939  PMID:22437504  PMCID:PMC3356457
    • Thompson, A. A., Liu, W., Chun, E., Katritch, V., Wu, H. X., Vardy, E., Huang, X. P., Trapella, C., Guerrini, R., Calo, G., Roth, B. L., Cherezov, V., et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Nature  2012 485:395-399  DOI:10.1038/nature11085  PMID:22596163  PMCID:PMC3356928
    • Garner, A. R., Rowland, D. C., Hwang, S. Y., Baumgaertel, K., Roth, B. L., Kentros, C., Mayford, M. Generation of a synthetic memory trace Science  2012 335:1513-1516  DOI:10.1126/science.1214985  PMID:22442487  PMCID:PMC3956300
    • Whitby, L. R., Ando, Y., Setola, V., Vogt, P. K., Roth, B. L., Boger, D. L. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions Journal of the American Chemical Society  2011 133:10184-10194  DOI:10.1021/ja201878v  PMID:21609016  PMCID:PMC3134394
    • Abbas, A. I., Hedlund, P. B., Huang, X. P., Tran, T. B., Meltzer, H. Y., Roth, B. L. Amisulpride is a potent 5-ht(7) antagonist: Relevance for antidepressant actions in vivo Psychopharmacology  2009 205:119-128  DOI:10.1007/s00213-009-1521-8  PMID:19337725  PMCID:PMC2821721

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