recent publications
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academic article
- O'Connor, C., White, K. L., Doncescu, N., Didenko, T., Roth, B. L., Czaplicki, G., Stevens, R. C., Wüthrich , K., Milon, A. NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor Proceedings of the National Academy of Sciences of the United States of America 2015 112:11852-11857 DOI:10.1073/pnas.1510117112 PMID:26372966 PMCID:PMC4586840
- Fenalti, G., Zatsepin, N. A., Betti, C., Giguere, P., Han, G. W., Ishchenko, A., Liu, W., Guillemyn, K., Zhang, H., James, D., Wang, D., Weierstall, U., et al. Structural basis for bifunctional peptide recognition at human delta-opioid receptor Nature Structural & Molecular Biology 2015 22:265-268 DOI:10.1038/nsmb.2965 PMID:25686086 PMCID:PMC4351130
- Wang, C., Wu, H., Evron, T., Vardy, E., Han, G. W., Huang, X. P., Hufeisen, S. J., Mangano, T. J., Urban, D. J., Katritch, V., Cherezov, V., Caron, M. G., et al. Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nature Communications 2014 5:4355 DOI:10.1038/ncomms5355 PMID:25008467 PMCID:PMC4198951
- Katritch, V., Fenalti, G., Abola, E. E., Roth, B. L., Cherezov, V., Stevens, R. C. Allosteric sodium in class A GPCR signaling Trends in Biochemical Sciences 2014 39:233-244 DOI:10.1016/j.tibs.2014.03.002 PMID:24767681 PMCID:PMC4106411
- Fenalti, G., Giguere, P. M., Katritch, V., Huang, X. P., Thompson, A. A., Cherezov, V., Roth, B. L., Stevens, R. C. Molecular control of delta-opioid receptor signalling Nature 2014 506:191-196 DOI:10.1038/nature12944 PMID:24413399 PMCID:PMC3931418
- Vardy, E., Mosier, P. D., Frankowski, K. J., Wu, H., Katritch, V., Westkaemper, R. B., Aube, J., Stevens, R. C., Roth, B. L. Chemotype-selective modes of action of κ-opioid receptor agonists Journal of Biological Chemistry 2013 288:34470-34483 DOI:10.1074/jbc.M113.515668 PMID:24121503 PMCID:PMC3843062
- Wang, C., Wu, H., Katritch, V., Han, G. W., Huang, X. P., Liu, W., Siu, F. Y., Roth, B. L., Cherezov, V., Stevens, R. C. Structure of the human smoothened receptor bound to an antitumour agent Nature 2013 497:338-343 DOI:10.1038/nature12167 PMID:23636324 PMCID:PMC3657389
- Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G. W., Liu, W., Huang, X. P., Vardy, E., McCorvy, J. D., Gao, X., et al. Structural basis for molecular recognition at serotonin receptors Science 2013 340:610-614 DOI:10.1126/science.1232807 PMID:23519210 PMCID:PMC3644373
- Wacker, D., Wang, C., Katritch, V., Han, G. W., Huang, X. P., Vardy, E., McCorvy, J. D., Jiang, Y., Chu, M., Siu, F. Y., Liu, W., Xu, H. E., et al. Structural features for functional selectivity at serotonin receptors Science 2013 340:615-619 DOI:10.1126/science.1232808 PMID:23519215 PMCID:PMC3644390
- Wu, H. X., Wacker, D., Mileni, M., Katritch, V., Han, G. W., Vardy, E., Liu, W., Thompson, A. A., Huang, X. P., Carroll, F. I., Mascarella, S. W., Westkaemper, R. B., et al. Structure of the human κ-opioid receptor in complex with JDTic Nature 2012 485:327-332 DOI:10.1038/nature10939 PMID:22437504 PMCID:PMC3356457
- Thompson, A. A., Liu, W., Chun, E., Katritch, V., Wu, H. X., Vardy, E., Huang, X. P., Trapella, C., Guerrini, R., Calo, G., Roth, B. L., Cherezov, V., et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Nature 2012 485:395-399 DOI:10.1038/nature11085 PMID:22596163 PMCID:PMC3356928
- Garner, A. R., Rowland, D. C., Hwang, S. Y., Baumgaertel, K., Roth, B. L., Kentros, C., Mayford, M. Generation of a synthetic memory trace Science 2012 335:1513-1516 DOI:10.1126/science.1214985 PMID:22442487 PMCID:PMC3956300
- Whitby, L. R., Ando, Y., Setola, V., Vogt, P. K., Roth, B. L., Boger, D. L. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions Journal of the American Chemical Society 2011 133:10184-10194 DOI:10.1021/ja201878v PMID:21609016 PMCID:PMC3134394
- Abbas, A. I., Hedlund, P. B., Huang, X. P., Tran, T. B., Meltzer, H. Y., Roth, B. L. Amisulpride is a potent 5-ht(7) antagonist: Relevance for antidepressant actions in vivo Psychopharmacology 2009 205:119-128 DOI:10.1007/s00213-009-1521-8 PMID:19337725 PMCID:PMC2821721