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N-alpha-2-mercaptobenzylamine-assisted chemical ligation

Academic Article
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Overview

authors

  • Offer, J.
  • Dawson, Philip

publication date

  • January 2000

journal

  • Organic Letters  Journal

abstract

  • [reaction: see text] The selective formation of an amide bond in the presence of unprotected functional groups is a challenging problem of peptide chemistry. A 2-mercaptobenzyl group tethered at the N-terminus of model peptides was observed to facilitate amide bond formation when a peptide thioester was added under mild aqueous conditions.

subject areas

  • Chromatography, High Pressure Liquid
  • Cysteine
  • Kinetics
  • Peptides
  • Sulfhydryl Compounds
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol991184t

PubMed ID

  • 10814236
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Additional Document Info

start page

  • 23

end page

  • 26

volume

  • 2

issue

  • 1

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