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Effect of tetrahydrocannabinol on the hypothalamic-pituitary axis in the ovariectomized rhesus monkey

Academic Article
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Overview

authors

  • Smith, C. G.
  • Besch, N. F.
  • Smith, Roy
  • Besch, P. K.

publication date

  • 1979

journal

  • Fertility and Sterility  Journal

abstract

  • Single doses of delta9-tetrahydrocannabinol (THC) (5.0, 2.5, 1.25, or 0.625 mg/kg) can decrease the levels of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the ovariectomized rhesus monkey. The inhibition of gonadotropins (50% to 88%) lasts for 6 to 24 hours depending upon the dose of THC. There are no great differences in the responses of the two gonadotropins to THC. The inhibition of gonadotropin levels by THC appears to be at the level of the hypothalamus, since both LH and FSH are released from the pituitary gland in response to LH- releasing factor in the presence of THC.

subject areas

  • Animals
  • Castration
  • Dose-Response Relationship, Drug
  • Dronabinol
  • Female
  • Follicle Stimulating Hormone
  • Gonadotropin-Releasing Hormone
  • Haplorhini
  • Hypothalamo-Hypophyseal System
  • Luteinizing Hormone
  • Macaca
  • Macaca mulatta
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 0015-0282

PubMed ID

  • 108139
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Additional Document Info

start page

  • 335

end page

  • 339

volume

  • 31

issue

  • 3

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