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The paradoxical population genetics of plasmodium falciparum

Academic Article
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Overview

authors

  • Hartl, D. L.
  • Volkman, S. K.
  • Nielsen, K. M.
  • Barry, A. E.
  • Day, K. P.
  • Wirth, D. F.
  • Winzeler, Elizabeth

publication date

  • June 2002

journal

  • Trends in Parasitology  Journal

abstract

  • Among the leading causes of death in African children is cerebral malaria caused by the parasitic protozoan Plasmodium falciparum. Endemic forms of this disease are thought to have originated in central Africa 5000-10000 years ago, coincident with the innovation of slash-and-burn agriculture and the diversification of the Anopheles gambiae complex of mosquito vectors. Population genetic studies of P. falciparum have yielded conflicting results. Some evidence suggests that today's population includes multiple ancient lineages pre-dating human speciation. Other evidence suggests that today's population derives from only one, or a small number, of these ancient lineages. Resolution of this issue is important for the evaluation of the long-term efficacy of drug and immunological control strategies.

subject areas

  • Animals
  • Anopheles
  • Endemic Diseases
  • Evolution, Molecular
  • Genetic Variation
  • Humans
  • Malaria, Falciparum
  • Plasmodium falciparum
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Identity

International Standard Serial Number (ISSN)

  • 1471-4922

Digital Object Identifier (DOI)

  • 10.1016/s1471-4922(02)02268-7

PubMed ID

  • 12036741
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Additional Document Info

start page

  • 266

end page

  • 272

volume

  • 18

issue

  • 6

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