Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. Ii. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Oldstone, Michael
  • Dixon, F. J.

publication date

  • 1970

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells. The pathogenesis of the nonglomerular tissue injury of chronic LCM disease is apparently at least in part related to the interaction of circulating anti-LCM antibody with viral antigen at the tissue site. Trapping of circulating virus-antibody complexes in the glomerular filter is apparently the major cause of the glomerulonephritis.

subject areas

  • Animals
  • Animals, Newborn
  • Antibody Formation
  • Antigen-Antibody Reactions
  • Brain
  • Brain Diseases
  • Complement Fixation Tests
  • Female
  • Glomerulonephritis
  • Hypersensitivity, Delayed
  • Immune Sera
  • Inflammation
  • Liver
  • Liver Diseases
  • Lymphocytic Choriomeningitis
  • Maternal-Fetal Exchange
  • Mice
  • Neutralization Tests
  • Parabiosis
  • Pregnancy
  • Pregnancy, Animal
  • Spleen
  • Time Factors
scroll to property group menus

Identity

PubMed Central ID

  • PMC2138769

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.131.1.1

PubMed ID

  • 5460613
scroll to property group menus

Additional Document Info

start page

  • 1

end page

  • 19

volume

  • 131

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support