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The behavioral-effects of enkephalin analogs injected into the ventral tegmental area and globus pallidus

Academic Article
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Overview

authors

  • Joyce, E. M.
  • Koob, George
  • Strecker, R.
  • Iversen, S. D.
  • Bloom, Floyd

publication date

  • 1981

journal

  • Brain Research  Journal

abstract

  • Two stable analogues of enkephalin D-Ala2-Met5-enkephalinamide (DAMA) and D-Ala2,D-Leu5-enkephalin (DADLE) injected bilaterally into the ventral tegmental area (VTA) induced locomotion, characterized by bursts of morphine-like activity. The response of DADLE was blocked by systemic-alpha-flupenthixol (0.2 mg/kg) and naloxone (1 mg/kg). At higher doses of enkephalins in the VTA, stereotypy behaviour involving gnawing, became apparent. When injected bilaterally into the globus pallidus (GP), both analogues induced a dose-dependent increase in locomotor activity but stereotypy was not observed. The locomotor behaviour induced by DADLE was blocked by naloxone but not by alpha-flupenthixol. These results suggest that naloxone-sensitive opiate receptors modulate, at a number of different sites, the neural pathways involved in the expression of behavioural activity.

subject areas

  • Animals
  • Behavior, Animal
  • Endorphins
  • Enkephalin, Leucine-2-Alanine
  • Enkephalin, Methionine
  • Enkephalins
  • Flupenthixol
  • Globus Pallidus
  • Male
  • Motor Activity
  • Naloxone
  • Organ Specificity
  • Rats
  • Tegmentum Mesencephali
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(81)90784-8

PubMed ID

  • 7025963
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Additional Document Info

start page

  • 359

end page

  • 370

volume

  • 221

issue

  • 2

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