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Prodrug activation gated by a molecular "or" logic trigger

Academic Article
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  • Research
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Overview

authors

  • Amir, R. J.
  • Popkov, M.
  • Lerner, Richard
  • Barbas III, Carlos
  • Shabat, Doron

publication date

  • 2005

journal

  • Angewandte Chemie-International Edition  Journal

subject areas

  • Antibiotics, Antineoplastic
  • Cell Line, Tumor
  • Cell Proliferation
  • Chromatography, High Pressure Liquid
  • Doxorubicin
  • Drug Screening Assays, Antitumor
  • Fructose-Bisphosphate Aldolase
  • Humans
  • Immunoglobulin Fab Fragments
  • Logic
  • Models, Biological
  • Penicillin Amidase
  • Prodrugs
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Research

keywords

  • catalytic antibodies
  • drug delivery
  • enzymes
  • logic gates
  • prodrugs
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.200500842

PubMed ID

  • 15942963
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Additional Document Info

start page

  • 4378

end page

  • 4381

volume

  • 44

issue

  • 28

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