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Functions of skin-resident gamma delta T cells

Academic Article
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Overview

authors

  • MacLeod, A. S.
  • Havran, Wendy

publication date

  • July 2011

journal

  • Cellular and Molecular Life Sciences  Journal

abstract

  • The murine epidermis contains resident T cells that express a canonical ?? TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low levels of cytokines and growth factors that contribute to epidermal homeostasis. Upon activation, DETC can secrete large amounts of inflammatory molecules which participate in the communication between DETC, neighboring keratinocytes and langerhans cells. Chemokines produced by DETC may recruit inflammatory cells to the epidermis. In addition, cell-cell mediated immune responses also appear important for epidermal-T cell communication. Information is provided which supports a crucial role for DETC in inflammation, wound healing, and tumor surveillance.
  • The murine epidermis contains resident T cells that express a canonical γδ TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low levels of cytokines and growth factors that contribute to epidermal homeostasis. Upon activation, DETC can secrete large amounts of inflammatory molecules which participate in the communication between DETC, neighboring keratinocytes and langerhans cells. Chemokines produced by DETC may recruit inflammatory cells to the epidermis. In addition, cell-cell mediated immune responses also appear important for epidermal-T cell communication. Information is provided which supports a crucial role for DETC in inflammation, wound healing, and tumor surveillance.

subject areas

  • Animals
  • Cell Communication
  • Homeostasis
  • Keratinocytes
  • Langerhans Cells
  • Mice
  • Models, Immunological
  • Receptors, Antigen, T-Cell, gamma-delta
  • Skin
  • T-Lymphocytes
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Research

keywords

  • DETC
  • Homeostasis
  • Inflammation
  • Skin tumors
  • Wound healing
  • gamma delta T cells
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Identity

PubMed Central ID

  • PMC3123394

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/s00018-011-0702-x

PubMed ID

  • 21560071
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Additional Document Info

start page

  • 2399

end page

  • 2408

volume

  • 68

issue

  • 14

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