recent publications

• academic article

  • Zhang, Y., Desharnais, J., Marsilje, T. H., Li, C. L., Hedrick, M. P., Gooljarsingh, L. T., Tavassoli, A., Benkovic, S. J., Olson, A. J., Boger, D. L., Wilson, I. A. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid Biochemistry  2003 42:6043-6056  DOI:10.1021/bi034219c  PMID:12755606
  • Marsilje, T. H., Labroli, M. A., Hedrick, M. P., Jin, Q., Desharnais, J., Baker, S. J., Gooljarsingh, L. T., Ramcharan, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Beardsley, G. P., et al. 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2002 10:2739-2749  DOI:10.1016/s0968-0896(02)00102-5  PMID:12057663
  • Boger, D. L., Kochanny, M. J., Cai, H., Wyatt, D., Kitos, P. A., Warren, M. S., Ramcharan, J., Gooljarsingh, L. T., Benkovic, S. J. Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors Bioorganic & Medicinal Chemistry  1998 6:643-659  DOI:10.1016/s0968-0896(98)00040-6  PMID:9681131
  • Boger, D. L.*, Haynes, N. E.*, Warren, M. S., Gooljarsingh, L. T., Ramcharan, J., Kitos, P. A., Benkovic, S. J. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of gar tfase or aicar tfase Bioorganic & Medicinal Chemistry  1997 5:1831-1838  DOI:10.1016/s0968-0896(97)00121-1  PMID:9354238 (* = equal contribution)