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Epstein-Barr-virus complement C3d receptor is an interferon-alpha receptor

Academic Article
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Overview

authors

  • Delcayre, A. X.
  • Salas, F.
  • Mathur, S.
  • Kovats, K.
  • Lotz, Martin
  • Lernhardt, W.

publication date

  • April 1991

journal

  • EMBO Journal  Journal

abstract

  • Interferon alpha contains a sequence motif similar to the complement receptor type two (CR2/CD21) binding site on complement fragment C3d. Antibodies against a peptide with the CR2 binding sequence on C3d react with a peptide carrying the IFN alpha CR2 binding motif (residues 92-99) and with recombinant IFN alpha. The IFN alpha-derived peptide, as well as recombinant IFN alpha, inhibits C3bi/C3d interaction with CR2 on the Burkitt lymphoma Raji. The direct interaction of IFN alpha and CR2 is inhibited by polyclonal anti-IFN alpha, anti-CR2 and anti-C3d peptide antibodies as well as by C3bi/C3d, EBV coat protein gp350/220 and IFN but not by IFN gamma. [125I]IFN alpha binding to Raji cells is inhibited by polyclonal anti-IFN alpha and anti-CR2 antibodies, by peptides with the CR2 binding motif and partially by C3bi/C3d. Monoclonal anti-CR2 antibody HB5, but not OKB-7, blocks IFN alpha binding to Raji cells. CR2 or CR2-like molecules may therefore be the major IFN alpha receptors on B lymphocytes.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antigens, Differentiation, B-Lymphocyte
  • B-Lymphocytes
  • Cell Line
  • Complement C3d
  • Enzyme-Linked Immunosorbent Assay
  • Herpesvirus 4, Human
  • Humans
  • Interferon Type I
  • L Cells (Cell Line)
  • Lymphocyte Activation
  • Mice
  • Molecular Sequence Data
  • Receptors, Complement
  • Receptors, Complement 3d
  • Receptors, Immunologic
  • Receptors, Interferon
  • Receptors, Virus
  • Recombinant Proteins
  • Rosette Formation
  • Sequence Homology, Nucleic Acid
  • Transfection
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Research

keywords

  • C3D RECEPTOR
  • EBV
  • INTERFERON-ALPHA RECEPTOR
  • LYMPHOCYTES
  • RECEPTOR BINDING MOTIF
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Identity

PubMed Central ID

  • PMC452735

International Standard Serial Number (ISSN)

  • 0261-4189

PubMed ID

  • 1849076
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Additional Document Info

start page

  • 919

end page

  • 926

volume

  • 10

issue

  • 4

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