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Iterative in situ click chemistry creates antibody-like protein-capture agents

Academic Article
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Overview

authors

  • Agnew, H. D.
  • Rohde, R. D.
  • Millward, S. W.
  • Nag, A.
  • Yeo, W. S.
  • Hein, J. E.
  • Pitram, S. M.
  • Tariq, A. A.
  • Burns, V. M.
  • Krom, R. J.
  • Fokin, Valery
  • Sharpless, K. Barry
  • Heath, J. R.

publication date

  • 2009

journal

  • Angewandte Chemie-International Edition  Journal

abstract

  • Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the creation of a peptide library enable the fragment-based assembly of selective high-affinity protein-capture agents. The resulting ligands are water-soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)-catalyzed cycloaddition.

subject areas

  • Antibodies
  • Catalysis
  • Copper
  • Ligands
  • Peptide Library
  • Peptides
  • Protein Binding
  • Proteins
  • Triazoles
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Research

keywords

  • click chemistry
  • combinatorial chemistry
  • inhibitors
  • peptides
  • protein-capture agents
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Identity

PubMed Central ID

  • PMC3716464

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.200900488

PubMed ID

  • 19301344
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Additional Document Info

start page

  • 4944

end page

  • 4948

volume

  • 48

issue

  • 27

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