Iterative in situ click chemistry creates antibody-like protein-capture agents

Academic Article

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Overview

authors

• Agnew, H. D.
• Rohde, R. D.
• Millward, S. W.
• Nag, A.
• Yeo, W. S.
• Hein, J. E.
• Pitram, S. M.
• Tariq, A. A.
• Burns, V. M.
• Krom, R. J.
• Fokin, Valery
• Sharpless, K. Barry
• Heath, J. R.

publication date

• 2009

journal

• Angewandte Chemie-International Edition  Journal

abstract

• Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the creation of a peptide library enable the fragment-based assembly of selective high-affinity protein-capture agents. The resulting ligands are water-soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)-catalyzed cycloaddition.

subject areas

• Antibodies
• Catalysis
• Copper
• Ligands
• Peptide Library
• Peptides
• Protein Binding
• Proteins
• Triazoles

Research

keywords

• click chemistry
• combinatorial chemistry
• inhibitors
• peptides
• protein-capture agents

Identity

PubMed Central ID

• PMC3716464

International Standard Serial Number (ISSN)

• 1433-7851

Digital Object Identifier (DOI)

• 10.1002/anie.200900488

PubMed ID

• 19301344

Additional Document Info

start page

• 4944

end page

• 4948

volume

• 48

issue

• 27