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A common antiviral cytotoxic lymphocyte-t epitope for diverse major histocompatibility complex haplotypes - implications for vaccination

Academic Article
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Overview

authors

  • Oldstone, Michael
  • Tishon, A.
  • Geckeler, R.
  • Lewicki, H.
  • Whitton, J. Lindsay

publication date

  • April 1992

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Of nine established murine haplotypes, mice of three types (H-2d, H-2u, and H-2q) possess major histocompatibility complex class I glycoproteins able to present an identical viral peptide for recognition and lysis by virus-specific cytotoxic T lymphocytes. Incorporation of this viral epitope into a recombinant vaccinia vaccine and administration of a single dose protects mice with these three haplotypes from an ordinarily lethal challenge of virus. Hence, a common epitope can exist. The sharing of the ability to bind such epitopes among different MHC haplotypes underscores the feasibility of developing an effective cytotoxic T-lymphocyte vaccine for outbred populations like humans.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antigen-Presenting Cells
  • Antigens, Viral
  • Epitopes
  • H-2 Antigens
  • Haplotypes
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Major Histocompatibility Complex
  • Mice
  • Molecular Sequence Data
  • Peptides
  • T-Lymphocytes, Cytotoxic
  • Vaccination
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.89.7.2752

PubMed ID

  • 1372990
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Additional Document Info

start page

  • 2752

end page

  • 2755

volume

  • 89

issue

  • 7

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