Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Biros, Shannon Marie, Ph.D. in Organic Chemistry, Scripps Research 2001 - 2006

authors

  • Barr, A. M.
  • Kinney, J. W.
  • Hill, M. N.
  • Lu, Xiaoying
  • Biros, Shannon Marie
  • Rebek Jr., Julius
  • Bartfai, Tamas

publication date

  • September 2006

journal

  • Neuroscience Letters  Journal

abstract

  • The neuropeptide galanin is widely expressed in limbic nuclei in the brain, and plays an important role in the regulation of homeostatic and affective behaviors, in part through its modulation of central monoamine pathways. Recent evidence suggests that galanin and its receptors may be involved in the efficacy of various modalities of antidepressant treatments. We have previously demonstrated that systemically active, non-peptide galanin receptor type-1/2 agonists exhibit antidepressant-like effects in the rat forced swim test. Here we evaluate a novel galanin receptor type-3 (GalR3) antagonist in preclinical tests of anxiety and depression. At multiple doses, the compound displayed no effects in the elevated plus maze in mice. By contrast, the compound decreased time spent immobile in the tail suspension test by mice. Additionally, the GalR3 drug decreased time spent immobile in the forced swim test in rats, similarly to the effects of desipramine, yet did not increase locomotor activity in an open field test. These combined data from two species indicate that GalR3 receptor antagonists may exhibit antidepressant-like effects.

subject areas

  • Animals
  • Antidepressive Agents
  • Drug Evaluation, Preclinical
  • Imines
  • Indoles
  • Ligands
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Pyridines
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Galanin, Type 3
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2006.06.033

PubMed ID

  • 16854525
scroll to property group menus

Additional Document Info

start page

  • 111

end page

  • 115

volume

  • 405

issue

  • 1-2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support