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Unrestricted recognition of a nonpeptide antigen by CD8+ cytolytic T lymphocytes

Academic Article
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Overview

authors

  • Sherman, Linda
  • Lara, A. M.

publication date

  • December 1989

journal

  • Journal of Immunology  Journal

abstract

  • CD8+ murine CTL that are specific for an unusual nonpeptide Ag, the heme moiety of hemoglobin, have been derived by in vitro stimulation of spleen cells with hemin. Such CTL demonstrate a requirement for the expression of class I Ag on target cells, yet appear to be unrestricted to the extent that both syngeneic and allogeneic targets precoated with hemin are sensitive to lysis. A series of CTL clones with specificity for hemin was derived from C57BL/6 mice. They exhibited the same type of promiscuous recognition that was observed in CTL populations from a number of different strains. The possibility that hemin acts as a nonspecific mediator of lysis by CTL was ruled out by the fact that a variety of CTL populations and clones specific for different Ag did not exhibit hemin-specific lysis. Some explanations offered to explain these results include 1) the possibility that hemin is recognized by binding to a site on the MHC other than the Ag-binding groove, and 2) the possibility that TCR recognition of a rigid molecule, such as hemin, may be less sensitive to polymorphic variation in the MHC than is recognition of a conventional peptide Ag whose conformation may differ significantly when bound to MHC molecules whose sequences differ within the Ag-binding groove.

subject areas

  • Animals
  • Antigen-Presenting Cells
  • Antigens, CD8
  • Antigens, Differentiation, T-Lymphocyte
  • Cell Line
  • Clone Cells
  • Epitopes
  • H-2 Antigens
  • Heme
  • Hemin
  • Histocompatibility Antigens Class II
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • T-Lymphocytes, Cytotoxic
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 2479678
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Additional Document Info

start page

  • 3444

end page

  • 3447

volume

  • 143

issue

  • 11

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