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Cloned cytotoxic T lymphocytes as target cells. II. Polarity of lysis revisited

Academic Article
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Overview

authors

  • Gorman, K.
  • Liu, C. C.
  • Blakely, A.
  • Young, J. D. E.
  • Torbett, Bruce
  • Clark, W. R.

publication date

  • October 1988

journal

  • Journal of Immunology  Journal

abstract

  • The original polarity of lysis experiments suggested that CTL are themselves sensitive to whatever mechanism it is that CTL use to lyse their targets. This concept has placed certain limitations on possible mechanisms of lysis by CTL. Recently, we found in studies with cloned CTL as targets that cloned CTL are in fact highly resistant to lysis by other CTL, as well as to their cytotoxic granule proteins. We show here that although cloned CTL are extremely resistant to lysis by primary and cloned CTL, they are readily inactivated functionally by all primary CTL and by at least one CTL clone. Moreover, cloned CTL are also functionally inactivated by cytotoxic granule proteins. The activation of CTL, which we call inhibitin, is Ca2+ insensitive and distinct from hemolytic activity, and is, thus, unlikely to be perforin. These experiments suggest a possible alternative interpretation of the original polarity of lysis experiments.

subject areas

  • Animals
  • Clone Cells
  • Cytoplasmic Granules
  • Cytotoxicity Tests, Immunologic
  • Cytotoxicity, Immunologic
  • Female
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Peptides
  • T-Lymphocytes, Cytotoxic
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 3262651
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Additional Document Info

start page

  • 2211

end page

  • 2215

volume

  • 141

issue

  • 7

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