Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Cognition enhancement strategies

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Bibb, J. A.
  • Mayford, Mark
  • Tsien, J. Z.
  • Alberini, C. M.

publication date

  • November 2010

journal

  • Journal of Neuroscience  Journal

abstract

  • Many mental disorders and neurodegenerative and neurodevelopmental diseases involve cognitive deficits. Remarkable advances and new technologies are providing a clearer picture of the molecular basis of cognition. In conjunction with an SFN2010 symposium, we provided here a brief overview of the molecular mechanisms of cognition, with emphasis on the development of treatments for cognitive disorders. Activity-dependent changes in gene expression and protein synthesis integrate with synapse selection to form memory circuits. A neuronal activity-dependent molecular tagging system that uses the gene expression program to record memory circuit formation represents one new tool to study cognition. Regulation of protein translation, protein degradation, cytoskeletal dynamics, extracellular matrix interactions, second messenger signaling, and neurotransmitter receptor trafficking and function are all components of synaptic remodeling essential for cognition. Selective targeting of specific effectors in these processes, such as NMDA receptors, may serve as an effective strategy to treat cognitive deficits.

subject areas

  • Animals
  • Cognition
  • Epigenesis, Genetic
  • Gene Expression
  • Humans
  • Learning
  • Nerve Net
  • Neuronal Plasticity
  • Neurons
  • Synapses
  • Synaptic Transmission
scroll to property group menus

Identity

PubMed Central ID

  • PMC3425350

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.4419-10.2010

PubMed ID

  • 21068302
scroll to property group menus

Additional Document Info

start page

  • 14987

end page

  • 14992

volume

  • 30

issue

  • 45

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support