recent publications
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academic article
- Madoux, F., Janovick, J. A., Smithson, D., Fargue, S., Danpure, C. J., Scampavia, L., Chen, Y. T., Spicer, T. P., Conn, P. M. Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening Assay and Drug Development Technologies 2015 13:16-24 DOI:10.1089/adt.2014.627 PMID:25710543
- Li, J., Huang, J., Jeong, J. H., Park, S. J., Wei, R., Peng, J., Luo, Z., Chen, Y. T., Feng, Y., Luo, J. L. Selective TBK1/IKKi dual inhibitors with anticancer potency International Journal of Cancer 2014 134:1972-1980 DOI:10.1002/ijc.28507 PMID:24150799 PMCID:PMC3947486
- Andero, R., Brothers, S. P., Jovanovic, T., Chen, Y. T., Salah-Uddin, H., Cameron, M., Bannister, T. D., Almli, L., Stevens, J. S., Bradley, B., Binder, E. B., Wahlestedt, C., et al. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD Science Translational Medicine 2013 5:188ra73 DOI:10.1126/scitranslmed.3005656 PMID:23740899 PMCID:PMC3732318
- Chowdhury, S., Chen, Y. T., Fang, X. G., Grant, W., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Park, H., Schroter, T., Bannister, T. D., LoGrasso, P. V., et al. Amino acid derived quinazolines as Rock/PKA inhibitors Bioorganic & Medicinal Chemistry Letters 2013 23:1592-1599 DOI:10.1016/j.bmcl.2013.01.109 PMID:23416002
- Zhou, Y. C., Agudelo, J., Lu, K., Goetz, D. H., Hansell, E., Chen, Y. T., Roush, W. R., McKerrow, J., Craik, C. S., Amberg, S. M., Simmons, G. Inhibitors of SARS-CoV entry: identification using an internally-controlled dual envelope pseudovirion assay Antiviral Research 2011 92:187-194 DOI:10.1016/j.antiviral.2011.07.016 PMID:21820471 PMCID:PMC3205982
- Fang, X. A., Chen, Y. T., Sessions, E. H., Chowdhury, S., Vojkovsky, T., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., et al. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:1844-1848 DOI:10.1016/j.bmcl.2011.01.039 PMID:21349713
- Chen, Y. T., Vojkovsky, T., Fang, X. G., Pocas, J. R., Grant, W., Handy, A. M. W., Schroter, T., LoGrasso, P., Bannister, T. D., Fang, Y. B. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors MedChemComm 2011 2:73-75 DOI:10.1039/c0md00194e
- Chen, Y. T., Brinen, L. S., Kerr, I. D., Hansell, E., Doyle, P. S., McKerrow, J. H., Roush, W. R. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi PLoS Neglected Tropical Diseases 2010 4:e825 DOI:10.1371/journal.pntd.0000825 PMID:20856868 PMCID:PMC2939063
- Fang, X. G., Yin, Y., Chen, Y. T., Yao, L., Wang, B., Cameron, M. D., Lin, L., Khan, S., Ruiz, C., Schroter, T., Grant, W., Weiser, A., et al. Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors Journal of Medicinal Chemistry 2010 53:5727-5737 DOI:10.1021/jm100579r PMID:20684608
- Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schroter, T., Grant, W., Pocas, J., Chen, Y. T., Schurer, S., Pachori, A., LoGrasso, P., Feng, Y. B. Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats ACS Medicinal Chemistry Letters 2010 1:175-179 DOI:10.1021/ml1000382 PMID:24900192 PMCID:PMC4007833
- Sessions, E. H., Smolinski, M., Wang, B., Frackowiak, B., Chowdhury, S., Yin, Y., Chen, Y. T., Ruiz, C., Lin, L., Pocas, J., Schroter, T., Cameron, M. D., et al. The development of benzimidazoles as selective Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2010 20:1939-1943 DOI:10.1016/j.bmcl.2010.01.124 PMID:20167489
- Chen, Y. T., Bannister, T. D., Weiser, A., Griffin, E., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., Duckett, D., Schroter, T., LoGrasso, P., Feng, Y. B. Chroman-3-amides as potent Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:6406-6409 DOI:10.1016/j.bmcl.2008.10.080 PMID:18990570
- Chen, Y. T., Lira, R., Hansell, E., McKerrow, J. H., Roush, W. R. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:5860-5863 DOI:10.1016/j.bmcl.2008.06.012 PMID:18585034 PMCID:PMC2642929
- Goetz, D. H., Choe, Y., Hansell, E., Chen, Y. T., McDowell, M., Jonsson, C. B., Roush, W. R., McKerrow, J., Craik, C. S. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus Biochemistry 2007 46:8744-8752 DOI:10.1021/bi0621415 PMID:17605471
- Melendez-Lopez, S. G., Herdman, S., Hirata, K., Choi, M. H., Choe, Y., Craik, C., Caffrey, C. R., Hansell, E., Chavez-Munguia, B., Chen, Y. T., Roush, W. R., McKerrow, J., et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell 2007 6:1130-1136 DOI:10.1128/ec.00094-07 PMID:17513563 PMCID:PMC1951106