recent publications

• academic article

  • Madoux, F., Janovick, J. A., Smithson, D., Fargue, S., Danpure, C. J., Scampavia, L., Chen, Y. T., Spicer, T. P., Conn, P. M. Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening Assay and Drug Development Technologies  2015 13:16-24  DOI:10.1089/adt.2014.627  PMID:25710543
  • Li, J., Huang, J., Jeong, J. H., Park, S. J., Wei, R., Peng, J., Luo, Z., Chen, Y. T., Feng, Y., Luo, J. L. Selective TBK1/IKKi dual inhibitors with anticancer potency International Journal of Cancer  2014 134:1972-1980  DOI:10.1002/ijc.28507  PMID:24150799  PMCID:PMC3947486
  • Andero, R., Brothers, S. P., Jovanovic, T., Chen, Y. T., Salah-Uddin, H., Cameron, M., Bannister, T. D., Almli, L., Stevens, J. S., Bradley, B., Binder, E. B., Wahlestedt, C., et al. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD Science Translational Medicine  2013 5:188ra73  DOI:10.1126/scitranslmed.3005656  PMID:23740899  PMCID:PMC3732318
  • Chowdhury, S., Chen, Y. T., Fang, X. G., Grant, W., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Park, H., Schroter, T., Bannister, T. D., LoGrasso, P. V., et al. Amino acid derived quinazolines as Rock/PKA inhibitors Bioorganic & Medicinal Chemistry Letters  2013 23:1592-1599  DOI:10.1016/j.bmcl.2013.01.109  PMID:23416002
  • Zhou, Y. C., Agudelo, J., Lu, K., Goetz, D. H., Hansell, E., Chen, Y. T., Roush, W. R., McKerrow, J., Craik, C. S., Amberg, S. M., Simmons, G. Inhibitors of SARS-CoV entry: identification using an internally-controlled dual envelope pseudovirion assay Antiviral Research  2011 92:187-194  DOI:10.1016/j.antiviral.2011.07.016  PMID:21820471  PMCID:PMC3205982
  • Fang, X. A., Chen, Y. T., Sessions, E. H., Chowdhury, S., Vojkovsky, T., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., et al. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2011 21:1844-1848  DOI:10.1016/j.bmcl.2011.01.039  PMID:21349713
  • Chen, Y. T., Vojkovsky, T., Fang, X. G., Pocas, J. R., Grant, W., Handy, A. M. W., Schroter, T., LoGrasso, P., Bannister, T. D., Fang, Y. B. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors MedChemComm  2011 2:73-75  DOI:10.1039/c0md00194e
  • Chen, Y. T., Brinen, L. S., Kerr, I. D., Hansell, E., Doyle, P. S., McKerrow, J. H., Roush, W. R. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi PLoS Neglected Tropical Diseases  2010 4:e825  DOI:10.1371/journal.pntd.0000825  PMID:20856868  PMCID:PMC2939063
  • Fang, X. G., Yin, Y., Chen, Y. T., Yao, L., Wang, B., Cameron, M. D., Lin, L., Khan, S., Ruiz, C., Schroter, T., Grant, W., Weiser, A., et al. Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors Journal of Medicinal Chemistry  2010 53:5727-5737  DOI:10.1021/jm100579r  PMID:20684608
  • Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schroter, T., Grant, W., Pocas, J., Chen, Y. T., Schurer, S., Pachori, A., LoGrasso, P., Feng, Y. B. Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats ACS Medicinal Chemistry Letters  2010 1:175-179  DOI:10.1021/ml1000382  PMID:24900192  PMCID:PMC4007833
  • Sessions, E. H., Smolinski, M., Wang, B., Frackowiak, B., Chowdhury, S., Yin, Y., Chen, Y. T., Ruiz, C., Lin, L., Pocas, J., Schroter, T., Cameron, M. D., et al. The development of benzimidazoles as selective Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2010 20:1939-1943  DOI:10.1016/j.bmcl.2010.01.124  PMID:20167489
  • Chen, Y. T., Bannister, T. D., Weiser, A., Griffin, E., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., Duckett, D., Schroter, T., LoGrasso, P., Feng, Y. B. Chroman-3-amides as potent Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2008 18:6406-6409  DOI:10.1016/j.bmcl.2008.10.080  PMID:18990570
  • Chen, Y. T., Lira, R., Hansell, E., McKerrow, J. H., Roush, W. R. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors Bioorganic & Medicinal Chemistry Letters  2008 18:5860-5863  DOI:10.1016/j.bmcl.2008.06.012  PMID:18585034  PMCID:PMC2642929
  • Goetz, D. H., Choe, Y., Hansell, E., Chen, Y. T., McDowell, M., Jonsson, C. B., Roush, W. R., McKerrow, J., Craik, C. S. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus Biochemistry  2007 46:8744-8752  DOI:10.1021/bi0621415  PMID:17605471
  • Melendez-Lopez, S. G., Herdman, S., Hirata, K., Choi, M. H., Choe, Y., Craik, C., Caffrey, C. R., Hansell, E., Chavez-Munguia, B., Chen, Y. T., Roush, W. R., McKerrow, J., et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell  2007 6:1130-1136  DOI:10.1128/ec.00094-07  PMID:17513563  PMCID:PMC1951106