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Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid

Academic Article
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Overview

authors

  • Rossier, J.
  • Bloom, Floyd
  • Guillemin, R.

publication date

  • 1979

journal

  • Science  Journal

abstract

  • Immunoreactive beta-endorphin was measured in the ventricular fluid of six patients with chronic pain. Stimulation of the periaqueductal gray matter in three patients with pain of peripheral origin resulted in significant increases (50 to 300 percent) in the concentration of ventricular immunoreactive beta-endorphin. In three other patients suffering deafferentation dysesthesia, stimulation of the posterior limb of the internal capsule did not alter the concentration of this peptide. These results provide evidence of the release of human immunoreactive beta-endorphin in vivo and suggest that naloxone-reversible pain relief achieved by stimulation of the periaqueductal gray matter may be in part mediated by the activation of beta-endorphin-rich diencephalic areas.

subject areas

  • Aged
  • Brain
  • Cerebral Aqueduct
  • Electric Stimulation
  • Endorphins
  • Enkephalins
  • Female
  • Humans
  • Male
  • Middle Aged
  • Palliative Care
  • Radioimmunoassay
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

PubMed ID

  • 83674
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Additional Document Info

start page

  • 279

end page

  • 281

volume

  • 203

issue

  • 4377

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