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Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

Academic Article
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  • Research
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Overview

authors

  • Chang, Y. T.
  • Gray, N. S.
  • Rosania, G. R.
  • Sutherlin, D. P.
  • Kwon, S.
  • Norman, T. C.
  • Sarohia, R.
  • Leost, M.
  • Meijer, L.
  • Schultz, Peter

publication date

  • June 1999

journal

  • Chemistry & Biology  Journal

subject areas

  • Adenine
  • Binding Sites
  • CDC2 Protein Kinase
  • Cell Cycle
  • Cell Division
  • Cyclin A
  • Cyclin B
  • Cyclin-Dependent Kinases
  • Enzyme Inhibitors
  • Humans
  • Ligands
  • Models, Molecular
  • Protein Conformation
  • Purines
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
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Research

keywords

  • 2,6,9-trisubstituted purine library
  • CDK inhibitor
  • apoptosis
  • cell-based assay
  • cell-cycle arrest
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Identity

International Standard Serial Number (ISSN)

  • 1074-5521

Digital Object Identifier (DOI)

  • 10.1016/s1074-5521(99)80048-9

PubMed ID

  • 10375538
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Additional Document Info

start page

  • 361

end page

  • 375

volume

  • 6

issue

  • 6

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