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In vivo release of enkephalin from the globus pallidus

Academic Article
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Overview

authors

  • Bayon, A.
  • Shoemaker, W. J.
  • Lugo, L.
  • Azad, R.
  • Ling, N.
  • Druckercolin, R. R.
  • Bloom, Floyd

publication date

  • 1981

journal

  • Neuroscience Letters  Journal

abstract

  • Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the perfusing medium. Local perfusion with veratrine also enhanced enkephalin release. Furthermore, in vivo, electrical stimulation of the rat caudo-putamen enhanced enkephalin release in the pallidum. This latter finding is consistent with a functional strio-pallidal enkephalin-containing pathway previously postulated by immunohistochemical or lesion experiments.

subject areas

  • Animals
  • Calcium
  • Cats
  • Endorphins
  • Enkephalins
  • Globus Pallidus
  • Kinetics
  • Perfusion
  • Potassium
  • Rats
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(81)90360-8

PubMed ID

  • 7266940
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Additional Document Info

start page

  • 65

end page

  • 70

volume

  • 24

issue

  • 1

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