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Targeting plasmid-encoded proteins to the antigen presentation pathways

Academic Article
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Overview

authors

  • Leifert, J. A.
  • Rodriguez-Carreno, M. P.
  • Rodriguez, F.
  • Whitton, J. Lindsay

publication date

  • June 2004

journal

  • Immunological Reviews  Journal

abstract

  • The antigen presentation pathways constitute a fulcrum on which adaptive immunity is balanced, and their manipulation should allow us to induce designer immune responses. The ease and rapidity with which DNA vaccines can be constructed and altered make them ideal candidates with which to test the various targeting strategies that have been conceived to date. These approaches and the mechanisms that may (or may not) underlie their success are reviewed in this article.

subject areas

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells
  • Cross-Priming
  • Epitopes
  • Histocompatibility Antigens
  • Humans
  • Plasmids
  • Proteins
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes
  • Vaccines, DNA
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Identity

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.0105-2896.2004.0135.x

PubMed ID

  • 15233725
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Additional Document Info

start page

  • 40

end page

  • 53

volume

  • 199

issue

  • 1

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