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A soluble polymer-supported triflating reagent: A high-throughput synthetic approach to aryl and enol triflates

Academic Article
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Overview

authors

  • Wentworth, A. D.
  • Wentworth Jr., Paul
  • Mansoor, U. F.
  • Janda, Kim

publication date

  • February 2000

journal

  • Organic Letters  Journal

abstract

  • [reaction: see text] The high-yielding synthesis and application of the first example of a polymer-supported reagent for the preparation of trifluoromethanesulfonates (triflates) is described. This new reagent efficiently triflates aryl alcohols and lithium enolates in high yield (>90%). A simple precipitation and filtration to remove the excess reagent and byproduct facilitate purification of the triflate products. The PEG-supported approach is highly efficient, as the PEG-supported byproduct can be quantitatively recovered and recycled into reagent 1.

subject areas

  • Indicators and Reagents
  • Mesylates
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol9913237

PubMed ID

  • 10814355
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Additional Document Info

start page

  • 477

end page

  • 480

volume

  • 2

issue

  • 4

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