recent publications

• academic article

  • Moldt, B., Rakasz, E. G., Schultz, N., Chan-Hui, P. Y., Swiderek, K., Weisgrau, K. L., Piaskowski, S. M., Bergman, Z., Watkins, D. I., Poignard, P., Burton, D. R. Highly potent hiv-specific antibody neutralization in vitro translates into effective protection against mucosal shiv challenge in vivo Proceedings of the National Academy of Sciences of the United States of America  2012 109:18921-18925  DOI:10.1073/pnas.1214785109  PMID:23100539  PMCID:PMC3503218
  • Poignard, P., Moldt, B., Maloveste, K., Campos, N., Olson, W. C., Rakasz, E., Watkins, D. I., Burton, D. R. Protection against high-dose highly pathogenic mucosal siv challenge at very low serum neutralizing titers of the antibody-like molecule cd4-igg2 PLoS One  2012 7:e42209  DOI:10.1371/journal.pone.0042209  PMID:22848744  PMCID:PMC3407103
  • Moldt, B., Shibata-Koyama, M., Rakasz, E. G., Schultz, N., Kanda, Y., Dunlop, D. C., Finstad, S. L., Jin, C. G., Landucci, G., Alpert, M. D., Dugast, A. S., Parren, Pwhi, et al. A nonfucosylated variant of the anti-hiv-1 monoclonal antibody b12 has enhanced fc gamma riiia-mediated antiviral activity in vitro but does not improve protection against mucosal shiv challenge in macaques Journal of Virology  2012 86:6189-6196  DOI:10.1128/jvi.00491-12  PMID:22457527  PMCID:PMC3372207
  • Reynolds, M. R., Weiler, A. M., Piaskowski, S. M., Kolar, H. L., Hessell, A. J., Weiker, M., Weisgrau, K. L., Leon, E. J., Rogers, W. E., Makowsky, R., McDermott, A. B., Boyle, R., et al. Macaques vaccinated with simian immunodeficiency virus sivmac239 delta nef delay acquisition and control replication after repeated low-dose heterologous siv challenge Journal of Virology  2010 84:9190-9199  DOI:10.1128/jvi.00041-10  PMID:20592091  PMCID:PMC2937616
  • Hessell, A. J., Rakasz, E. G., Tehrani, D. M., Huber, M., Weisgrau, K. L., Landucci, G., Forthal, D. N., Koff, W. C., Poignard, P., Watkins, D. I., Burton, D. R. Broadly neutralizing monoclonal antibodies 2f5 and 4e10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus shivba-l Journal of Virology  2010 84:1302-1313  DOI:10.1128/jvi.01272-09  PMID:19906907  PMCID:PMC2812338
  • Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I., Burton, D. R. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers PLoS Pathogens  2009 5:e1000433  DOI:10.1371/journal.ppat.1000433  PMID:19436712  PMCID:PMC2674935
  • Reynolds, M. R., Weiler, A. M., Weisgrau, K. L., Piaskowski, S. M., Furlott, J. R., Weinfurter, J. T., Kaizu, M., Soma, T., Leon, E. J., MacNair, C., Leaman, D. P., Zwick, M. B., et al. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus Journal of Experimental Medicine  2008 205:2537-2550  DOI:10.1084/jem.20081524  PMID:18838548  PMCID:PMC2571929
  • Watkins, D. I., Burton, D. R., Kallas, E. G., Moore, J. P., Koff, W. C. Nonhuman primate models and the failure of the merck hiv-1 vaccine in humans Nature Medicine  2008 14:617-621  DOI:10.1038/nm.f.1759  PMID:18535579  PMCID:PMC3697853
  • Wilson, N. A., Reed, J., Napoe, G. S., Piaskowski, S., Szymanski, A., Furlott, J., Gonzalez, E. J., Yant, L. J., Maness, N. J., May, G. E., Soma, T., Reynolds, M. R., et al. Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus sivmac239 Journal of Virology  2006 80:5875-5885  DOI:10.1128/jvi.00171-06  PMID:16731926
  • Koff, W. C., Johnson, P. R., Watkins, D. I., Burton, D. R., Lifson, J. D., Hasenkrug, K. J., McDermott, A. B., Schultz, A., Zamb, T. J., Boyle, R., Desrosiers, R. C. HIV vaccine design: Insights from live attenuated siv vaccines Nature Immunology  2006 7:19-23  DOI:10.1038/ni1296  PMID:16357854
  • Bui, H. H., Sidney, J., Peters, B., Sathiamurthy, M., Sinichi, A., Purton, K. A., Mothe, B. R., Chisari, F. V., Watkins, D. I., Sette, A. Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications Immunogenetics  2005 57:304-314  DOI:10.1007/s00251-005-0798-y  PMID:15868141
  • O'Connor, D. H., McDermott, A. B., Krebs, K. C., Dodds, E. J., Miller, J. E., Gonzalez, E. J., Jacoby, T. J., Yant, L., Piontkivska, H., Pantophlet, R., Burton, D. R., Rehrauer, W. M., et al. A dominant role for cd8+-t-lymphocyte selection in simian immunodeficiency virus sequence variation Journal of Virology  2004 78:14012-14022  DOI:10.1128/jvi.78.24.14012.14022.2004  PMID:15564508
  • O'Connor, D. H., Mothe, B. R., Weinfurter, J. T., Fuenger, S., Rehrauer, W. M., Jing, P. C., Rudersdorf, R. R., Liebl, M. E., Krebs, K., Vasquez, J., Dodds, E., Loffredo, J., et al. Major histocompatibility complex class i alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-t-lymphocyte responses Journal of Virology  2003 77:9029-9040  DOI:10.1128/jvi.77.16.9029-9040.2003  PMID:12885919