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Molecular profiles of schizophrenia in the cns at different stages of illness

Academic Article
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Overview

authors

  • Narayan, S.
  • Tang, B.
  • Head, Steve
  • Gilmartin, T. J.
  • Sutcliffe, J. Gregor
  • Dean, B.
  • Thomas, Elizabeth

publication date

  • November 2008

journal

  • Brain Research  Journal

abstract

  • Results from clinical and imaging studies provide evidence for changes in schizophrenia with disease progression, however, the underlying molecular differences that may occur at different stages of illness have not been investigated. To test the hypothesis that the molecular basis for schizophrenia changes from early to chronic illness, we profiled genome-wide expression patterns in prefrontal cortex of schizophrenic subjects at different stages of illness, along with their age- and sex-matched controls. Results show that gene expression profiles change dramatically depending on the stage of illness, whereby the greatest number and magnitude of gene expression differences were detected in subjects with short-term illness (

subject areas

  • Adult
  • Aged
  • Cohort Studies
  • Disease Progression
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Humans
  • Inflammation
  • Male
  • Metals
  • Prefrontal Cortex
  • RNA Processing, Post-Transcriptional
  • Schizophrenia
  • Time Factors
  • Transport Vesicles
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Research

keywords

  • Antipsychotic
  • Chronic
  • Immune
  • Microarray
  • Psychiatric disorder
  • Schizophrenia
  • Transcription factor
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Identity

PubMed Central ID

  • PMC2783475

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/j.brainres.2008.08.023

PubMed ID

  • 18778695
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Additional Document Info

start page

  • 235

end page

  • 248

volume

  • 1239

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