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Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice

Academic Article
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Overview

authors

  • Kim, H. S.
  • Jang, Choon-Gon
  • Park, W. K.
  • Oh, K. W.
  • Rheu, H. M.
  • Cho, D. H.
  • Oh, S. K.

publication date

  • March 1996

journal

  • General Pharmacology  Journal

abstract

  • Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.

subject areas

  • Animals
  • Apomorphine
  • Behavior, Animal
  • Central Nervous System Stimulants
  • Dopamine Agonists
  • Homing Behavior
  • Male
  • Methamphetamine
  • Mice
  • Motor Activity
  • Panax
  • Plants, Medicinal
  • Saponins
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Research

keywords

  • conditioned place preference
  • dopamine receptor supersensitivity
  • hyperactivity
  • methamphetamine
  • panax ginseng
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Identity

International Standard Serial Number (ISSN)

  • 0306-3623

Digital Object Identifier (DOI)

  • 10.1016/0306-3623(95)02023-3

PubMed ID

  • 8919631
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Additional Document Info

start page

  • 199

end page

  • 204

volume

  • 27

issue

  • 2

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