Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic lymphocyte-t activity - implications for control of viral disease

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Gairin, J. E.
  • Oldstone, Michael

publication date

  • November 1992

journal

  • Journal of Virology  Journal

abstract

  • Cytotoxic T lymphocytes (CTLs) recognize viral antigens presented by infected cells in the context of their major histocompatibility complex glycoproteins. The irreversible killing of virus-infected cells by virus-specific CTLs can be the cause of serious disease, particularly in the central nervous, hepatic, and cardiovascular systems. Design of molecules controlling (blocking) interaction between CTLs and infected cells, and their further use to inhibit (or antagonize) T-lymphocyte activity, is an important pharmacologic goal. In this report, we describe the design of a new family of peptides which selectively inhibit activity of lymphocytic choriomeningitis virus-specific CD8+ T lymphocytes, which recognize endogenously processed viral epitopes presented by major histocompatibility complex class I molecules.

subject areas

  • Alanine
  • Amino Acid Sequence
  • Animals
  • Antigens, Viral
  • Asparagine
  • Cell Line
  • Chromium Radioisotopes
  • Cytotoxicity Tests, Immunologic
  • Cytotoxicity, Immunologic
  • Drug Design
  • Epitopes
  • H-2 Antigens
  • Lymphocytic choriomeningitis virus
  • Major Histocompatibility Complex
  • Mice
  • Molecular Sequence Data
  • Peptide Fragments
  • T-Lymphocytes, Cytotoxic
  • Virus Diseases
scroll to property group menus

Identity

PubMed Central ID

  • PMC240172

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 1383569
scroll to property group menus

Additional Document Info

start page

  • 6755

end page

  • 6762

volume

  • 66

issue

  • 11

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support