Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

The human retinal degeneration slow (rds) gene - chromosome assignment and structure of the messenger-rna

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Travis, G. H.
  • Christerson, L.
  • Danielson, P. E.
  • Klisak, I.
  • Sparkes, R. S.
  • Hahn, L. B.
  • Dryja, T. P.
  • Sutcliffe, J. Gregor

publication date

  • July 1991

journal

  • Genomics  Journal

abstract

  • Retinal degeneration slow (rds) is a mouse neurological mutation that is characterized phenotypically by abnormal development of rod and cone photoreceptors followed by their slow degeneration. This phenotype resembles the pathologic abnormalities seen in retinitis pigmentosa. The mouse rds gene has recently been cloned. Here we present the sequence of a full-length cDNA clone of the human RDS mRNA. We show that in human retina there are two RDS transcripts of 3.0 and 5.5 kb. By analysis of DNA from a panel of human X hamster somatic cell hybrids, and by direct in situ hybridization, we show that the RDS gene is located on the proximal short arm of human chromosome 6. Finally, we present information on the frequency of several observed restriction fragment length polymorphisms using the RDS cDNA. This information is of potential value for testing linkage of the RDS gene to the disease phenotype in families with retinitis pigmentosa.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cattle
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6
  • Cricetinae
  • Cricetulus
  • DNA
  • Disease Models, Animal
  • Eye Proteins
  • Genes
  • Humans
  • Hybrid Cells
  • Intermediate Filament Proteins
  • Membrane Glycoproteins
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Peripherins
  • Phenotype
  • Polymorphism, Restriction Fragment Length
  • Rats
  • Retinal Degeneration
  • Retinitis Pigmentosa
  • Sequence Homology, Nucleic Acid
  • Species Specificity
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1016/0888-7543(91)90457-p

PubMed ID

  • 1679750
scroll to property group menus

Additional Document Info

start page

  • 733

end page

  • 739

volume

  • 10

issue

  • 3

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support