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Synthesis and DNA binding properties of saturated distamycin analogues

Academic Article
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Overview

authors

  • Woods, C. R.
  • Faucher, N.
  • Eschgfaller, B.
  • Bair, K. W.
  • Boger, Dale

publication date

  • September 2002

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • A series of saturated heterocyclic analogues of distamycin were prepared and examined. A fluorescent intercalator displacement (FID) assay conducted on p[dA]-p[dT] DNA to obtain C(50) values and a hairpin deoxyoligonucleotide containing an A/T-rich binding site was used to evaluate DNA binding affinity. It is observed that saturated heterocycles greatly reduce the DNA binding relative to distamycin.

subject areas

  • DNA
  • Distamycins
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(02)00467-5

PubMed ID

  • 12182879
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Additional Document Info

start page

  • 2647

end page

  • 2650

volume

  • 12

issue

  • 18

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