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Lysophosphatidic acid receptors

Academic Article
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Overview

authors

  • Contos, J. J. A.
  • Ishii, I.
  • Chun, Jerold

publication date

  • 2000

journal

  • Molecular Pharmacology  Journal

abstract

  • Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, lp(A1)/vzg-1/Edg2, lp(A2)/Edg4, and lp(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

subject areas

  • Amino Acid Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4
  • Female
  • Humans
  • Molecular Sequence Data
  • Ovarian Neoplasms
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Sequence Homology, Amino Acid
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Identity

International Standard Serial Number (ISSN)

  • 0026-895X

PubMed ID

  • 11093753
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Additional Document Info

start page

  • 1188

end page

  • 1196

volume

  • 58

issue

  • 6

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