Lysophosphatidic acid receptors

Academic Article

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Overview

authors

• Contos, J. J. A.
• Ishii, I.
• Chun, Jerold

publication date

• 2000

journal

• Molecular Pharmacology  Journal

abstract

• Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes, lp(A1)/vzg-1/Edg2, lp(A2)/Edg4, and lp(A3)/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.

subject areas

• Amino Acid Sequence
• Chromosome Mapping
• Chromosomes, Human, Pair 4
• Female
• Humans
• Molecular Sequence Data
• Ovarian Neoplasms
• Receptors, Cell Surface
• Receptors, G-Protein-Coupled
• Receptors, Lysophosphatidic Acid
• Sequence Homology, Amino Acid

Identity

International Standard Serial Number (ISSN)

• 0026-895X

PubMed ID

• 11093753

Additional Document Info

start page

• 1188

end page

• 1196

volume

• 58

issue

• 6