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Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM)

Academic Article
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Overview

authors

  • Del Maschio, A.
  • De Luigi, A.
  • Martin-Padura, I.
  • Brockhaus, M.
  • Bartfai, Tamas
  • Fruscella, P.
  • Adorini, L.
  • Martino, G. V.
  • Furlan, R.
  • De Simoni, M. G.
  • Dejana, E.

publication date

  • November 1999

journal

  • Journal of Experimental Medicine  Journal

abstract

  • The mechanisms that govern leukocyte transmigration through the endothelium are not yet fully defined. Junctional adhesion molecule (JAM) is a newly cloned member of the immunoglobulin superfamily which is selectively concentrated at tight junctions of endothelial and epithelial cells. A blocking monoclonal antibody (BV11 mAb) directed to JAM was able to inhibit monocyte transmigration through endothelial cells in in vitro and in vivo chemotaxis assays. In this study, we report that BV11 administration was able to attenuate cytokine-induced meningitis in mice. The intravenous injection of BV11 mAb significantly inhibited leukocyte accumulation in the cerebrospinal fluid and infiltration in the brain parenchyma. Blood-brain barrier permeability was also reduced by the mAb. We conclude that JAM may be a new target in limiting the inflammatory response that accompanies meningitis.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Blood-Brain Barrier
  • Brain
  • Cell Adhesion Molecules
  • Chemotaxis
  • Cytokines
  • Disease Models, Animal
  • Eosinophils
  • Fluorescent Antibody Technique
  • Inflammation
  • Interleukin-1
  • Junctional Adhesion Molecules
  • Leukocytes
  • Meningitis
  • Mice
  • Microscopy, Fluorescence
  • Monocytes
  • Time Factors
  • Tumor Necrosis Factor-alpha
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Research

keywords

  • blood-brain barrier
  • endothelium
  • meningitis
  • tight junction
  • vascular permeability
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Identity

PubMed Central ID

  • PMC2195675

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.190.9.1351

PubMed ID

  • 10544206
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Additional Document Info

start page

  • 1351

end page

  • 1356

volume

  • 190

issue

  • 9

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