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Chemical synthesis and biological properties of pyridine epothilones

Academic Article
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Overview

authors

  • Nicolaou, K.C.
  • Scarpelli, R.
  • Bollbuck, B.
  • Werschkun, B.
  • Pereira, M. M. A.
  • Wartmann, M.
  • Altmann, K. H.
  • Zaharevitz, D.
  • Gussio, R.
  • Giannakakou, P.

publication date

  • August 2000

journal

  • Chemistry & Biology  Journal

subject areas

  • Antineoplastic Agents
  • Cell Division
  • Drug Design
  • Drug Evaluation, Preclinical
  • Drug Resistance, Neoplasm
  • Epothilones
  • Epoxy Compounds
  • Humans
  • Inhibitory Concentration 50
  • Macrolides
  • Models, Molecular
  • Molecular Structure
  • Pyridines
  • Structure-Activity Relationship
  • Thiazoles
  • Tubulin
  • Tumor Cells, Cultured
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Research

keywords

  • antitumor activity
  • chemical synthesis
  • epothilones
  • molecular modeling
  • pyridine epothilones
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Identity

International Standard Serial Number (ISSN)

  • 1074-5521

Digital Object Identifier (DOI)

  • 10.1016/s1074-5521(00)00006-5

PubMed ID

  • 11048950
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Additional Document Info

start page

  • 593

end page

  • 599

volume

  • 7

issue

  • 8

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