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Protective effects of oligosaccharides in P-selectin-dependent lung injury

Academic Article
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Overview

authors

  • Mulligan, M. S.
  • Paulson, James
  • Defrees, S.
  • Zheng, Z. L.
  • Lowe, J. B.
  • Ward, P. A.

publication date

  • July 1993

journal

  • Nature  Journal

abstract

  • Neutrophil recruitment into tissues is a multistep process involving sequential engagement of adhesion molecules, including selectins (E,P,L), which are reactive with oligosaccharides, and the family of beta 2 integrins which are reactive with endothelial intercellular adhesion molecules. These processes result in the initial rolling of leukocytes along the endothelial surfaces, followed by the firm attachment of leukocytes to the endothelium. The intravenous infusion of cobra venom factor into rats results in acute lung injury that is neutrophil-dependent, oxygen radical mediated and P-selectin-dependent. Here we report that infusion of sialyl-Lewis X, a ligand for P-selectin, dramatically reduced lung injury and diminished the tissue accumulation of neutrophils, whereas irrelevant oligosaccharides had no such effects. These results suggest that sialyl-Lewis X carbohydrates may be used as a new strategy for anti-inflammatory therapy.

subject areas

  • Animals
  • Antigens, CD15
  • Carbohydrate Sequence
  • Cell Adhesion Molecules
  • Cell Movement
  • Cobra Venoms
  • Dose-Response Relationship, Drug
  • Lung Diseases
  • Molecular Sequence Data
  • Neutrophils
  • P-Selectin
  • Platelet Membrane Glycoproteins
  • Rats
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/364149a0

PubMed ID

  • 7686631
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Additional Document Info

start page

  • 149

end page

  • 151

volume

  • 364

issue

  • 6433

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