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Click chemistry in situ: Acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

Academic Article
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Overview

related to degree

  • Lewis, Warren G, Ph.D. in Chemistry, Scripps Research 1999 - 2005

authors

  • Lewis, Warren G
  • Green, L. G.
  • Grynszpan, F.
  • Radic, Z.
  • Carlier, P. R.
  • Taylor, P.
  • Finn, M.G.
  • Sharpless, K. Barry

publication date

  • 2002

journal

  • Angewandte Chemie-International Edition  Journal

subject areas

  • Acetylcholinesterase
  • Animals
  • Binding Sites
  • Cholinesterase Inhibitors
  • Combinatorial Chemistry Techniques
  • Drug Design
  • Kinetics
  • Mice
  • Torpedo
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Research

keywords

  • combinatorial chemistry
  • cycloaddition
  • heterocycles
  • hydrolases
  • inhibitors
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/1521-3773(20020315)41:6<1053::aid-anie1053>3.0.co;2-4

PubMed ID

  • 12491310
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Additional Document Info

start page

  • 1053

end page

  • 1057

volume

  • 41

issue

  • 6

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