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Ruiz, C.

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    • Asteian, A., Blayo, A. L., He, Y., Koenig, M., Shin, Y., Kuruvilla, D. S., Corzo, C. A., Lin, L., Ruiz, C., Khan, S., Kumar, N., Busby, S. Design, synthesis, and biological evaluation of indole biphenylcarboxylic acids as PPARγ antagonists ACS Medicinal Chemistry Letters  2015 6:998-1003  DOI:10.1021/acsmedchemlett.5b00218  PMID:26396687  PMCID:PMC4569877
    • Ruiz, C., Li, J., Luttgen, M. S., Kolatkar, A., Kendall, J. T., Flores, E., Topp, Z., Samlowski, W. E., McClay, E., Bethel, K., Ferrone, S., Hicks, J., et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients Physical Biology  2015 12  DOI:10.1088/1478-3975/12/1/016008  PMID:25574741  PMCID:PMC5023009
    • Choi, J. Y., Calvet, C. M., Gunatilleke, S. S., Ruiz, C., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents Journal of Medicinal Chemistry  2013 56:7651-7668  DOI:10.1021/jm401067s  PMID:24079662  PMCID:PMC3864028
    • Yin, Y., Lin, L., Ruiz, C., Khan, S., Cameron, M. D., Grant, W., Pocas, J., Eid, N., Park, H., Schroter, T., Lograsso, P. V., Feng, Y. Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors Journal of Medicinal Chemistry  2013 56:3568-3581  DOI:10.1021/jm400062r  PMID:23570561
    • Chowdhury, S., Chen, Y. T., Fang, X. G., Grant, W., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Park, H., Schroter, T., Bannister, T. D., LoGrasso, P. V., et al. Amino acid derived quinazolines as Rock/PKA inhibitors Bioorganic & Medicinal Chemistry Letters  2013 23:1592-1599  DOI:10.1016/j.bmcl.2013.01.109  PMID:23416002
    • Sessions, E. H., Chowdhury, S., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., LoGrasso, P., Bannister, T. D., Feng, Y. B. Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II) Bioorganic & Medicinal Chemistry Letters  2011 21:7113-7118  DOI:10.1016/j.bmcl.2011.09.084  PMID:22018789
    • Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., LoGrasso, P., Bannister, T. D., Feng, Y. B. Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I) Bioorganic & Medicinal Chemistry Letters  2011 21:7107-7112  DOI:10.1016/j.bmcl.2011.09.083  PMID:22004718
    • Fang, X. A., Chen, Y. T., Sessions, E. H., Chowdhury, S., Vojkovsky, T., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., et al. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2011 21:1844-1848  DOI:10.1016/j.bmcl.2011.01.039  PMID:21349713
    • Fang, X. G., Yin, Y., Chen, Y. T., Yao, L., Wang, B., Cameron, M. D., Lin, L., Khan, S., Ruiz, C., Schroter, T., Grant, W., Weiser, A., et al. Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors Journal of Medicinal Chemistry  2010 53:5727-5737  DOI:10.1021/jm100579r  PMID:20684608
    • Sessions, E. H., Smolinski, M., Wang, B., Frackowiak, B., Chowdhury, S., Yin, Y., Chen, Y. T., Ruiz, C., Lin, L., Pocas, J., Schroter, T., Cameron, M. D., et al. The development of benzimidazoles as selective Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2010 20:1939-1943  DOI:10.1016/j.bmcl.2010.01.124  PMID:20167489
    • Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schroter, T., Chen, W. M., Duckett, D., Schurer, S., LoGrasso, P., Feng, Y. B. Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors Bioorganic & Medicinal Chemistry Letters  2009 19:6686-6690  DOI:10.1016/j.bmcl.2009.09.115  PMID:19837589
    • Sessions, E. H., Yin, Y., Bannister, T. D., Weiser, A., Griffin, E., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Schurer, S. C., Schroter, T., LoGrasso, P., et al. Benzimidazole- and benzoxazole-based inhibitors of Rho kinase Bioorganic & Medicinal Chemistry Letters  2008 18:6390-6393  DOI:10.1016/j.bmcl.2008.10.095  PMID:18996009
    • Chen, Y. T., Bannister, T. D., Weiser, A., Griffin, E., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., Duckett, D., Schroter, T., LoGrasso, P., Feng, Y. B. Chroman-3-amides as potent Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2008 18:6406-6409  DOI:10.1016/j.bmcl.2008.10.080  PMID:18990570
    • Feng, Y. B., Yin, Y., Weiser, A., Griffin, E., Cameron, M. D., Lin, L., Ruiz, C., Schurer, S. C., Inoue, T., Rao, P. V., Schroter, T., LoGrasso, P. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors Journal of Medicinal Chemistry  2008 51:6642-6645  DOI:10.1021/jm800986w  PMID:18834107  PMCID:PMC3708311
    • Feng, Y. B., Cameron, M. D., Frackowiak, B., Griffin, E., Lin, L., Ruiz, C., Schroter, T., LoGrasso, P. Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II Bioorganic & Medicinal Chemistry Letters  2007 17:2355-2360  DOI:10.1016/j.bmcl.2006.12.043  PMID:17368019

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