recent publications
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academic article
- Liao, H. X., Lynch, R., Zhou, T., Gao, F., Alam, S. M., Boyd, S. D., Fire, A. Z., Roskin, K. M., Schramm, C. A., Zhang, Z., Zhu, J., Shapiro, L., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature 2013 496:469-476 DOI:10.1038/nature12053 PMID:23552890 PMCID:PMC3637846
- Siggs, O. M., Cruite, J. T., Du, X., Rutschmann, S., Masliah, E., Beutler, B., Oldstone, M. B. A. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease Proceedings of the National Academy of Sciences of the United States of America 2012 109:13733-13738 DOI:10.1073/pnas.1211499109 PMID:22869751 PMCID:PMC3427069
- Rutschmann, S., Crozat, K., Li, X., Du, X., Hanselman, J. C., Shigeoka, A. A., Brandl, K., Popkin, D. L., McKay, D. B., Xia, Y., Moresco, E. M. Y., Beutler, B. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice G3-Genes Genomes Genetics 2012 2:499-504 DOI:10.1534/g3.112.002196 PMID:22540041 PMCID:PMC3337478
- Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., et al. ENU-induced phenovariance in mice: Inferences from 587 mutations BMC Research Notes 2012 5:577 DOI:10.1186/1756-0500-5-577 PMID:23095377 PMCID:PMC3532239
- Krieg, L., Milstein, O., Krebs, P., Xia, Y., Beutler, B., Du, X. Mutation of the gastric hydrogen-potassium atpase alpha subunit causes iron-deficiency anemia in mice Blood 2011 118:6418-6425 DOI:10.1182/blood-2011-04-350082 PMID:21976678 PMCID:PMC3236123
- Xia, C. H., Lu, E., Liu, H. Q., Du, X., Beutler, B., Gong, X. H. The role of vldlr in intraretinal angiogenesis in mice Investigative Ophthalmology & Visual Science 2011 52:6572-6579 DOI:10.1167/iovs.10-7082 PMID:21757581 PMCID:PMC3176028
- Xia, Y., Won, S., Du, X., Lin, P., Ross, C., La Vine, D., Wiltshire, S., Leiva, G., Vidal, S. M., Whittle, B., Goodnow, C. C., Koziol, J., et al. Bulk segregation mapping of mutations in closely related strains of mice Genetics 2010 186:1139-1146 DOI:10.1534/genetics.110.121160 PMID:20923982 PMCID:PMC2998299
- Brandl, K., Sun, L., Neppl, C., Siggs, O. M., Le Gall, S. M., Tomisato, W., Li, X. H., Du, X., Maennel, D. N., Blobel, C. P., Beutler, B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Proceedings of the National Academy of Sciences of the United States of America 2010 107:19967-19972 DOI:10.1073/pnas.1014669107 PMID:21041656 PMCID:PMC2993336
- Orinska, Z., Foger, N., Huber, M., Marschall, J., Mirghomizadeh, F., Du, X., Scheller, M., Rosenstiel, P., Goldmann, T., Bollinger, A., Beutler, B. A., Bulfone-Paus, S. I787 provides signals for c-kit receptor internalization and functionality that control mast cell survival and development Blood 2010 116:2665-2675 DOI:10.1182/blood-2009-06-228460 PMID:20595514
- Berger, M., Krebs, P., Crozat, K., Li, X. H., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., et al. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Nature Immunology 2010 11:335-343 DOI:10.1038/ni.1847 PMID:20190759 PMCID:PMC2861894
- Liu, H. Q., Wang, M., Xia, C. H., Du, X., Flannery, J. G., Ridge, K. D., Beutler, B., Gong, X. H. Severe retinal degeneration caused by a novel rhodopsin mutation Investigative Ophthalmology & Visual Science 2010 51:1059-1065 DOI:10.1167/iovs.09-3585 PMID:19741247 PMCID:PMC2868463
- Kono, D. H., Haraldsson, M. K., Lawson, B. R., Pollard, K. M., Koh, Y. T., Du, X., Arnold, C. N., Baccala, R., Silverman, G. J., Beutler, B. A., Theofilopoulos, A. N. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Proceedings of the National Academy of Sciences of the United States of America 2009 106:12061-12066 DOI:10.1073/pnas.0905441106 PMID:19574451 PMCID:PMC2715524
- Brandl, K., Rutschmann, S., Li, X. H., Du, X., Xiao, N. M., Schnabl, B., Brenner, D. A., Beutler, B. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Proceedings of the National Academy of Sciences of the United States of America 2009 106:3300-3305 DOI:10.1073/pnas.0813036106 PMID:19202076 PMCID:PMC2651297
- Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America 2008 105:14609-14614 DOI:10.1073/pnas.0807219105 PMID:18794526 PMCID:PMC2567147
- Xia, C. H., Liu, H. Q., Cheung, D., Wang, M., Cheng, C., Du, X., Chang, B., Beutler, B., Gong, X. H. A model for familial exudative vitreoretinopathy caused by LPR5 mutations Human Molecular Genetics 2008 17:1605-1612 DOI:10.1093/hmg/ddn047 PMID:18263894 PMCID:PMC2902293
- Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease tmprss6 is required to sense iron deficiency Science 2008 320:1088-1092 DOI:10.1126/science.1157121 PMID:18451267 PMCID:PMC2430097
- Georgel, P., Du, X., Hoebe, K., Beutler, B. ENU mutagenesis in mice Methods in Molecular Biology 2008 415:1-16 DOI:10.1007/978-1-59745-570-1_1 PMID:18370145
- Otsuka, M., Jing, Q., Georgel, P., New, L., Chen, J. M., Mols, J., Kang, Y. J., Jiang, Z. F., Du, X., Cook, R., Das, S. C., Pattnaik, A. K., et al. Hypersusceptibility to vesicular stomatitis virus infection in dicer1-deficient mice is due to impaired mir24 and mir93 expression Immunity 2007 27:123-134 DOI:10.1016/j.immuni.2007.05.014 PMID:17613256
- Meehan, T. P., Tabeta, K., Du, X., Woodward, L. S., Firozi, K., Beutler, B., Justice, M. J. Point mutations in the melanocortin-4 receptor cause variable obesity in mice Mammalian Genome 2006 17:1162-1171 DOI:10.1007/s00335-006-0073-z PMID:17143585
- Casrouge, A., Zhang, S. Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., Alcais, A., Picard, C., Mahfoufi, N., Nicolas, N., Lorenzo, L., Plancoulaine, S., et al. Herpes simplex virus encephalitis in human unc-93b deficiency Science 2006 314:308-312 DOI:10.1126/science.1128346 PMID:16973841
- Jiang, Z. F., Georgel, P., Li, C. L., Choe, J., Crozat, K., Rutschmann, S., Du, X., Bigby, T., Mudd, S., Sovath, S., Wilson, I. A., Olson, A. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Proceedings of the National Academy of Sciences of the United States of America 2006 103:10961-10966 DOI:10.1073/pnas.0603804103 PMID:16832055 PMCID:PMC1544157
- Rutschmann, S., Hoebe, K., Zalevsky, J., Du, X., Mann, N., Dahiyat, B. I., Steed, P., Beutler, B. PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development Journal of Immunology 2006 176:7525-7532 PMID:16751399
- Xia, C. H., Liu, H., Cheung, D., Cheng, C., Wang, E., Du, X., Beutler, B., Lo, W. K., Gong, X. H. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis Development 2006 133:2033-2040 DOI:10.1242/dev.02361 PMID:16611690
- Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K., Beutler, B. Analysis of the MCMV resistome by ENU mutagenesis Mammalian Genome 2006 17:398-406 DOI:10.1007/s00335-005-0164-2 PMID:16688530
- Huber, M., Kalis, C., Keck, S., Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Beutler, B., Galanos, C., Freudenberg, M. A. R-form lps, the master key to the activation of tlr4/md-2-positive cells European Journal of Immunology 2006 36:701-711 DOI:10.1002/eji.200535593 PMID:16506285
- Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology 2006 7:156-164 DOI:10.1038/ni1297 PMID:16415873
- Xia, C. H., Liu, H., Wang, M., Cheung, D., Park, A., Yang, Y., Du, X., Chang, B., Beutler, B., Gong, X. Characterization of mouse mutants with abnormal RPE cells Advances in Experimental Medicine and Biology 2006 572:95-100 DOI:10.1007/0-387-32442-9_15 PMID:17249561
- Beutler, B., Jiang, Z. F., Georgel, P., Crozat, K., Croker, B., Rutschmann, S., Du, X., Hoebe, K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large Annual Review of Immunology 2006 24:353-389 DOI:10.1146/annurev.immunol.24.021605.090552 PMID:16551253
- Hoebe, K., Jiang, Z., Georgel, P., Tabeta, K., Janssen, E., Du, X., Beutler, B. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy Current Pharmaceutical Design 2006 12:4123-4134 DOI:10.2174/138161206778743466 PMID:17100615
- Du, X., Tabeta, K., Mann, N., Crozat, K., Mudd, S., Beutler, B. An essential role for Rxr alpha in the development of Th2 responses European Journal of Immunology 2005 35:3414-3423 DOI:10.1002/eji.200535366 PMID:16259011
- Georgel, P., Crozat, K., Lauth, X., Makrantonaki, E., Seltmann, H., Sovath, S., Hoebe, K., Du, X., Rutschmann, S., Jiang, Z. F., Bigby, T., Nizet, V., et al. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria Infection and Immunity 2005 73:4512-4521 DOI:10.1128/iai.73.8.4512-4521.2005 PMID:16040962
- Liu, H. Q., Du, X., Wang, M., Huang, Q. L., Ding, L. L., McDonald, H. W., Yates, J. R., Beutler, B., Horwitz, J., Gong, X. H. Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency Journal of Biological Chemistry 2005 280:25071-25078 DOI:10.1074/jbc.M502490200 PMID:15878859
- Zhou, Z. P., Hoebe, K., Du, X., Jiang, Z. F., Shamel, L., Beutler, B. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation European Journal of Immunology 2005 35:1918-1927 DOI:10.1002/eji.200525971 PMID:15884053
- Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M., Beutler, B. Cd14 is required for myd88-independent lps signaling Nature Immunology 2005 6:565-570 DOI:10.1038/ni1207 PMID:15895089
- Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U., Beutler, B. Cd36 is a sensor of diacylglycerides Nature 2005 433:523-527 DOI:10.1038/nature03253 PMID:15690042
- Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Identification and function of the tir adapter proteins Advances in Experimental Medicine and Biology 2005 560:29-39 DOI:10.1007/0-387-24180-9_4 PMID:15934170
- Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Tir adapter proteins in innate and adaptive immune responses Microbes and Infection 2004 6:1374-1381 DOI:10.1016/j.micinf.2004.08.017 PMID:15596123
- Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proceedings of the National Academy of Sciences of the United States of America 2004 101:3516-3521 DOI:10.1073/pnas.0400525101 PMID:14993594 PMCID:PMC373494
- Du, X., Tabeta, K., Hoebe, K., Liu, H. Q., Mann, N., Mudd, S., Crozat, K., Sovath, S., Gong, X. H., Beutler, B. Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Genetics 2004 166:331-340 DOI:10.1534/genetics.166.1.331 PMID:15020428
- Beutler, B., Hoebe, K., Du, X., Ulevitch, R. J. How we detect microbes and respond to them: The toll-like receptors and their transducers Journal of Leukocyte Biology 2003 74:479-485 DOI:10.1189/jlb.0203082 PMID:12960260
- Beutler, B., Hoebe, K., Du, X., Janssen, E., Georgel, P., Tabeta, K. Lps2 and signal transduction in sepsis: At the intersection of host responses to bacteria and viruses Scandinavian Journal of Infectious Diseases 2003 35:563-567 DOI:10.1080/00365540310016295 PMID:14620135
- Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature 2003 424:743-748 DOI:10.1038/nature01889 PMID:12872135
- Beutler, B., Du, X., Hoebe, K. From phenomenon to phenotype and from phenotype to gene: Forward genetics and the problem of sepsis Journal of Infectious Diseases 2003 187:S321-S326 DOI:10.1086/374757 PMID:12792846
- Hoebe, K., Du, X., Goode, J., Mann, N., Beutler, B. Lps2: A new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening Journal of Endotoxin Research 2003 9:250-255 DOI:10.1179/096805103225001459 PMID:12935356
- Beutler, B., Du, X., Poltorak, A. Identification of toll-like receptor 4 (tlr4) as the sole conduit for lps signal transduction: Genetic and evolutionary studies Journal of Endotoxin Research 2001 7:277-280 DOI:10.1179/096805101101532846 PMID:11717581
- Du, X., Poltorak, A., Wei, Y. G., Beutler, B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution European Cytokine Network 2000 11:362-371 PMID:11022119
- Nattermann, J., Du, X., Wei, Y. G., Shevchenko, D., Beutler, B. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4 Journal of Endotoxin Research 2000 6:257-264 DOI:10.1179/096805100101532126 PMID:11052181
- Du, X., Poltorak, A., Silva, M., Beutler, B. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Blood Cells Molecules and Diseases 1999 25:328-338 DOI:10.1006/bcmd.1999.0262 PMID:10660480
- Poltorak, A., He, X. L., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene Science 1998 282:2085-2088 DOI:10.1126/science.282.5396.2085 PMID:9851930
- Poltorak, A., Smirnova, I., He, X. L., Liu, M. Y., Van Huffel, C., Birdwell, D., Alejos, E., Silva, M., Du, X., Thompson, P., Chan, E. F. L., Ledesma, J., et al. Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region Blood Cells Molecules and Diseases 1998 24:340-355 DOI:10.1006/bcmd.1998.0201 PMID:10087992