recent publications

• academic article

  • Liao, H. X., Lynch, R., Zhou, T., Gao, F., Alam, S. M., Boyd, S. D., Fire, A. Z., Roskin, K. M., Schramm, C. A., Zhang, Z., Zhu, J., Shapiro, L., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature  2013 496:469-476  DOI:10.1038/nature12053  PMID:23552890  PMCID:PMC3637846
  • Siggs, O. M., Cruite, J. T., Du, X., Rutschmann, S., Masliah, E., Beutler, B., Oldstone, M. B. A. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease Proceedings of the National Academy of Sciences of the United States of America  2012 109:13733-13738  DOI:10.1073/pnas.1211499109  PMID:22869751  PMCID:PMC3427069
  • Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., et al. ENU-induced phenovariance in mice: Inferences from 587 mutations BMC Research Notes  2012 5:577  DOI:10.1186/1756-0500-5-577  PMID:23095377  PMCID:PMC3532239
  • Rutschmann, S., Crozat, K., Li, X., Du, X., Hanselman, J. C., Shigeoka, A. A., Brandl, K., Popkin, D. L., McKay, D. B., Xia, Y., Moresco, E. M. Y., Beutler, B. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice G3-Genes Genomes Genetics  2012 2:499-504  DOI:10.1534/g3.112.002196  PMID:22540041  PMCID:PMC3337478
  • Krieg, L., Milstein, O., Krebs, P., Xia, Y., Beutler, B., Du, X. Mutation of the gastric hydrogen-potassium atpase alpha subunit causes iron-deficiency anemia in mice Blood  2011 118:6418-6425  DOI:10.1182/blood-2011-04-350082  PMID:21976678  PMCID:PMC3236123
  • Xia, C. H., Lu, E., Liu, H. Q., Du, X., Beutler, B., Gong, X. H. The role of vldlr in intraretinal angiogenesis in mice Investigative Ophthalmology & Visual Science  2011 52:6572-6579  DOI:10.1167/iovs.10-7082  PMID:21757581  PMCID:PMC3176028
  • Berger, M., Krebs, P., Crozat, K., Li, X. H., Croker, B. A., Siggs, O. M., Popkin, D., Du, X., Lawson, B. R., Theofilopoulos, A. N., Xia, Y., Khovananth, K., et al. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence Nature Immunology  2010 11:335-343  DOI:10.1038/ni.1847  PMID:20190759  PMCID:PMC2861894
  • Xia, Y., Won, S., Du, X., Lin, P., Ross, C., La Vine, D., Wiltshire, S., Leiva, G., Vidal, S. M., Whittle, B., Goodnow, C. C., Koziol, J., et al. Bulk segregation mapping of mutations in closely related strains of mice Genetics  2010 186:1139-1146  DOI:10.1534/genetics.110.121160  PMID:20923982  PMCID:PMC2998299
  • Orinska, Z., Foger, N., Huber, M., Marschall, J., Mirghomizadeh, F., Du, X., Scheller, M., Rosenstiel, P., Goldmann, T., Bollinger, A., Beutler, B. A., Bulfone-Paus, S. I787 provides signals for c-kit receptor internalization and functionality that control mast cell survival and development Blood  2010 116:2665-2675  DOI:10.1182/blood-2009-06-228460  PMID:20595514
  • Brandl, K., Sun, L., Neppl, C., Siggs, O. M., Le Gall, S. M., Tomisato, W., Li, X. H., Du, X., Maennel, D. N., Blobel, C. P., Beutler, B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands Proceedings of the National Academy of Sciences of the United States of America  2010 107:19967-19972  DOI:10.1073/pnas.1014669107  PMID:21041656  PMCID:PMC2993336
  • Liu, H. Q., Wang, M., Xia, C. H., Du, X., Flannery, J. G., Ridge, K. D., Beutler, B., Gong, X. H. Severe retinal degeneration caused by a novel rhodopsin mutation Investigative Ophthalmology & Visual Science  2010 51:1059-1065  DOI:10.1167/iovs.09-3585  PMID:19741247  PMCID:PMC2868463
  • Kono, D. H., Haraldsson, M. K., Lawson, B. R., Pollard, K. M., Koh, Y. T., Du, X., Arnold, C. N., Baccala, R., Silverman, G. J., Beutler, B. A., Theofilopoulos, A. N. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Proceedings of the National Academy of Sciences of the United States of America  2009 106:12061-12066  DOI:10.1073/pnas.0905441106  PMID:19574451  PMCID:PMC2715524
  • Brandl, K., Rutschmann, S., Li, X. H., Du, X., Xiao, N. M., Schnabl, B., Brenner, D. A., Beutler, B. Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response Proceedings of the National Academy of Sciences of the United States of America  2009 106:3300-3305  DOI:10.1073/pnas.0813036106  PMID:19202076  PMCID:PMC2651297
  • Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America  2008 105:14609-14614  DOI:10.1073/pnas.0807219105  PMID:18794526  PMCID:PMC2567147
  • Xia, C. H., Liu, H. Q., Cheung, D., Wang, M., Cheng, C., Du, X., Chang, B., Beutler, B., Gong, X. H. A model for familial exudative vitreoretinopathy caused by LPR5 mutations Human Molecular Genetics  2008 17:1605-1612  DOI:10.1093/hmg/ddn047  PMID:18263894  PMCID:PMC2902293
  • Georgel, P., Du, X., Hoebe, K., Beutler, B. ENU mutagenesis in mice Methods in Molecular Biology  2008 415:1-16  DOI:10.1007/978-1-59745-570-1_1  PMID:18370145
  • Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease tmprss6 is required to sense iron deficiency Science  2008 320:1088-1092  DOI:10.1126/science.1157121  PMID:18451267  PMCID:PMC2430097
  • Otsuka, M., Jing, Q., Georgel, P., New, L., Chen, J. M., Mols, J., Kang, Y. J., Jiang, Z. F., Du, X., Cook, R., Das, S. C., Pattnaik, A. K., et al. Hypersusceptibility to vesicular stomatitis virus infection in dicer1-deficient mice is due to impaired mir24 and mir93 expression Immunity  2007 27:123-134  DOI:10.1016/j.immuni.2007.05.014  PMID:17613256
  • Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K., Beutler, B. Analysis of the MCMV resistome by ENU mutagenesis Mammalian Genome  2006 17:398-406  DOI:10.1007/s00335-005-0164-2  PMID:16688530
  • Xia, C. H., Liu, H., Wang, M., Cheung, D., Park, A., Yang, Y., Du, X., Chang, B., Beutler, B., Gong, X. Characterization of mouse mutants with abnormal RPE cells Advances in Experimental Medicine and Biology  2006 572:95-100  DOI:10.1007/0-387-32442-9_15  PMID:17249561
  • Jiang, Z. F., Georgel, P., Li, C. L., Choe, J., Crozat, K., Rutschmann, S., Du, X., Bigby, T., Mudd, S., Sovath, S., Wilson, I. A., Olson, A. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Proceedings of the National Academy of Sciences of the United States of America  2006 103:10961-10966  DOI:10.1073/pnas.0603804103  PMID:16832055  PMCID:PMC1544157
  • Xia, C. H., Liu, H., Cheung, D., Cheng, C., Wang, E., Du, X., Beutler, B., Lo, W. K., Gong, X. H. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis Development  2006 133:2033-2040  DOI:10.1242/dev.02361  PMID:16611690
  • Beutler, B., Jiang, Z. F., Georgel, P., Crozat, K., Croker, B., Rutschmann, S., Du, X., Hoebe, K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large Annual Review of Immunology  2006 24:353-389  DOI:10.1146/annurev.immunol.24.021605.090552  PMID:16551253
  • Casrouge, A., Zhang, S. Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., Alcais, A., Picard, C., Mahfoufi, N., Nicolas, N., Lorenzo, L., Plancoulaine, S., et al. Herpes simplex virus encephalitis in human unc-93b deficiency Science  2006 314:308-312  DOI:10.1126/science.1128346  PMID:16973841
  • Rutschmann, S., Hoebe, K., Zalevsky, J., Du, X., Mann, N., Dahiyat, B. I., Steed, P., Beutler, B. PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development Journal of Immunology  2006 176:7525-7532  PMID:16751399
  • Meehan, T. P., Tabeta, K., Du, X., Woodward, L. S., Firozi, K., Beutler, B., Justice, M. J. Point mutations in the melanocortin-4 receptor cause variable obesity in mice Mammalian Genome  2006 17:1162-1171  DOI:10.1007/s00335-006-0073-z  PMID:17143585
  • Huber, M., Kalis, C., Keck, S., Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Beutler, B., Galanos, C., Freudenberg, M. A. R-form lps, the master key to the activation of tlr4/md-2-positive cells European Journal of Immunology  2006 36:701-711  DOI:10.1002/eji.200535593  PMID:16506285
  • Hoebe, K., Jiang, Z., Georgel, P., Tabeta, K., Janssen, E., Du, X., Beutler, B. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy Current Pharmaceutical Design  2006 12:4123-4134  DOI:10.2174/138161206778743466  PMID:17100615
  • Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology  2006 7:156-164  DOI:10.1038/ni1297  PMID:16415873
  • Georgel, P., Crozat, K., Lauth, X., Makrantonaki, E., Seltmann, H., Sovath, S., Hoebe, K., Du, X., Rutschmann, S., Jiang, Z. F., Bigby, T., Nizet, V., et al. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria Infection and Immunity  2005 73:4512-4521  DOI:10.1128/iai.73.8.4512-4521.2005  PMID:16040962
  • Du, X., Tabeta, K., Mann, N., Crozat, K., Mudd, S., Beutler, B. An essential role for Rxr alpha in the development of Th2 responses European Journal of Immunology  2005 35:3414-3423  DOI:10.1002/eji.200535366  PMID:16259011
  • Zhou, Z. P., Hoebe, K., Du, X., Jiang, Z. F., Shamel, L., Beutler, B. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation European Journal of Immunology  2005 35:1918-1927  DOI:10.1002/eji.200525971  PMID:15884053
  • Jiang, Z. F., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M., Beutler, B. Cd14 is required for myd88-independent lps signaling Nature Immunology  2005 6:565-570  DOI:10.1038/ni1207  PMID:15895089
  • Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U., Beutler, B. Cd36 is a sensor of diacylglycerides Nature  2005 433:523-527  DOI:10.1038/nature03253  PMID:15690042
  • Liu, H. Q., Du, X., Wang, M., Huang, Q. L., Ding, L. L., McDonald, H. W., Yates, J. R., Beutler, B., Horwitz, J., Gong, X. H. Crystallin gamma B-I4F mutant protein binds to alpha-crystallin and affects lens transparency Journal of Biological Chemistry  2005 280:25071-25078  DOI:10.1074/jbc.M502490200  PMID:15878859
  • Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Identification and function of the tir adapter proteins Advances in Experimental Medicine and Biology  2005 560:29-39  DOI:10.1007/0-387-24180-9_4  PMID:15934170
  • Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Tir adapter proteins in innate and adaptive immune responses Microbes and Infection  2004 6:1374-1381  DOI:10.1016/j.micinf.2004.08.017  PMID:15596123
  • Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proceedings of the National Academy of Sciences of the United States of America  2004 101:3516-3521  DOI:10.1073/pnas.0400525101  PMID:14993594  PMCID:PMC373494
  • Du, X., Tabeta, K., Hoebe, K., Liu, H. Q., Mann, N., Mudd, S., Crozat, K., Sovath, S., Gong, X. H., Beutler, B. Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Genetics  2004 166:331-340  DOI:10.1534/genetics.166.1.331  PMID:15020428
  • Beutler, B., Du, X., Hoebe, K. From phenomenon to phenotype and from phenotype to gene: Forward genetics and the problem of sepsis Journal of Infectious Diseases  2003 187:S321-S326  DOI:10.1086/374757  PMID:12792846
  • Beutler, B., Hoebe, K., Du, X., Ulevitch, R. J. How we detect microbes and respond to them: The toll-like receptors and their transducers Journal of Leukocyte Biology  2003 74:479-485  DOI:10.1189/jlb.0203082  PMID:12960260
  • Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature  2003 424:743-748  DOI:10.1038/nature01889  PMID:12872135
  • Beutler, B., Hoebe, K., Du, X., Janssen, E., Georgel, P., Tabeta, K. Lps2 and signal transduction in sepsis: At the intersection of host responses to bacteria and viruses Scandinavian Journal of Infectious Diseases  2003 35:563-567  DOI:10.1080/00365540310016295  PMID:14620135
  • Hoebe, K., Du, X., Goode, J., Mann, N., Beutler, B. Lps2: A new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening Journal of Endotoxin Research  2003 9:250-255  DOI:10.1179/096805103225001459  PMID:12935356
  • Beutler, B., Du, X., Poltorak, A. Identification of toll-like receptor 4 (tlr4) as the sole conduit for lps signal transduction: Genetic and evolutionary studies Journal of Endotoxin Research  2001 7:277-280  DOI:10.1179/096805101101532846  PMID:11717581
  • Nattermann, J., Du, X., Wei, Y. G., Shevchenko, D., Beutler, B. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4 Journal of Endotoxin Research  2000 6:257-264  DOI:10.1179/096805100101532126  PMID:11052181
  • Du, X., Poltorak, A., Wei, Y. G., Beutler, B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution European Cytokine Network  2000 11:362-371  PMID:11022119
  • Du, X., Poltorak, A., Silva, M., Beutler, B. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor Blood Cells Molecules and Diseases  1999 25:328-338  DOI:10.1006/bcmd.1999.0262  PMID:10660480
  • Poltorak, A., He, X. L., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene Science  1998 282:2085-2088  DOI:10.1126/science.282.5396.2085  PMID:9851930
  • Poltorak, A., Smirnova, I., He, X. L., Liu, M. Y., Van Huffel, C., Birdwell, D., Alejos, E., Silva, M., Du, X., Thompson, P., Chan, E. F. L., Ledesma, J., et al. Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region Blood Cells Molecules and Diseases  1998 24:340-355  DOI:10.1006/bcmd.1998.0201  PMID:10087992