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Classification of PDZ domains

Academic Article
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Overview

authors

  • Bezprozvanny, I.
  • Maximov, Anton

publication date

  • December 2001

journal

  • FEBS Letters  Journal

abstract

  • A diverse family of PDZ domains has been identified, but the rules that govern their ligand specificity are not clear. Here we propose a novel classification of PDZ domains based on the nature of amino acids in the two critical positions in the PDZ domain fold. Using these principles, we classified PDZ domains present in the SMART database. Using yeast two-hybrid, in vitro pull-down and plasmon surface resonance assays, we demonstrated that in agreement with their position in the proposed classification the Mint1-1, hINADL-5, and PAR6 PDZ domains display similar dual ligand specificity. The proposed classification helps to organize PDZ domain containing proteins.

subject areas

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins
  • Databases, Protein
  • Guanylate Kinase
  • Humans
  • Ligands
  • Membrane Proteins
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Phosphoproteins
  • Protein Binding
  • Protein Structure, Tertiary
  • Proteins
  • Rats
  • Sequence Homology, Amino Acid
  • Substrate Specificity
  • Surface Plasmon Resonance
  • Two-Hybrid System Techniques
  • Yeasts
  • Zonula Occludens-1 Protein
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Research

keywords

  • INADL
  • Mint1
  • PAR6
  • PDZ domain
  • primary sequence analysis
  • sequence database search
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Identity

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/s0014-5793(01)03214-8

PubMed ID

  • 11749973
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Additional Document Info

start page

  • 457

end page

  • 462

volume

  • 509

issue

  • 3

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