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The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators

Academic Article
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Overview

authors

  • Soliven, B.
  • Miron, V.
  • Chun, Jerold

publication date

  • February 2011

journal

  • Neurology  Journal

abstract

  • Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has recently been approved as the first oral treatment for relapsing forms of multiple sclerosis in some countries. Fingolimod has documented effects on lymphocyte egress, selectively retaining lymphocytes within the lymph nodes. In addition, fingolimod can enter the CNS and can act on S1PRs expressed by most neural lineages. In this article, we discuss recent results supporting the concept that S1PR modulators may exert neuroprotective and regenerative actions in the CNS as well as having anti-inflammatory effects.

subject areas

  • Animals
  • Blood-Brain Barrier
  • Central Nervous System
  • Fingolimod Hydrochloride
  • Humans
  • Immunologic Factors
  • Immunosuppressive Agents
  • Lymphocytes
  • Lysophospholipids
  • Neurobiology
  • Neuroglia
  • Neurons
  • Propylene Glycols
  • Receptors, Lysosphingolipid
  • Signal Transduction
  • Sphingosine
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Identity

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/WNL.0b013e31820d9507

PubMed ID

  • 21339490
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Additional Document Info

start page

  • S9

end page

  • S14

volume

  • 76

issue

  • 8

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